Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342–3p targeting of CASP1 in diabetic retinopathy

Yu, Xin-Yang; Ma, Xuefei; Lin, Wenjian; Qian, Xu; Zhou, Huanran; Kuang, Hongyu

doi:10.1016/j.exer.2020.108300

Cited by 54 publications

(54 citation statements)

References 35 publications

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“…The authors claimed that pyroptosis plays a critical role in DR progression. 142 Loukovaara et al have reported that caspase-1, ASC, and IL-18 expression levels are increased in PDR eyes. 143 NLRP3 inflammasome activation can be associated with the pathogenesis of PDR.…”

Section: Diabetic Retinopathymentioning

confidence: 99%

“… 142 The authors implemented advanced glycation end product modified bovine serum albumin (AGE-BSA) to induce DR progression and demonstrated that AGE-BSA triggered the cleavage of caspase-1 and GSDMD, release of IL-1β, IL-18, and LDH, and decreased cell viability. 142 Notably, Immunofluorescence staining indicated pyroptosis’s phenotypic features, such as pyknosis, swelling, cellular disruption, and hyperpermeability in plasmalemma. The authors claimed that pyroptosis plays a critical role in DR progression.…”

Section: Diabetic Retinopathymentioning

confidence: 99%

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Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Mamun¹,

Wu²,

Nasrin³

et al. 2021

JIR

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Pyroptosis is mainly considered as a new pro-inflammatory mediatedprogrammed cell death. In addition, pyroptosis is described by gasdermin-induced pore formation on the membrane, cell swelling and rapid lysis, and several pro-inflammatory mediators interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. Extensive studies have shown that pyroptosis is commonly involved by activating the caspase-1-dependent canonical pathway and caspase-4/5/11-dependent non-canonical pathway. However, pyroptosis facilitates local inflammation and inflammatory responses. Current researches have reported that pyroptosis promotes the progression of several diabetic complications. Emerging studies have suggested that some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. Our narrative review concisely describes the possible mechanism of pyroptosis and its progressive understanding of the development of diabetic complications.

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Section: Diabetic Retinopathymentioning

confidence: 99%

Section: Diabetic Retinopathymentioning

confidence: 99%

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Mamun¹,

Wu²,

Nasrin³

et al. 2021

JIR

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“…Furthermore, HG induces retinal pericyte pyroptosis through the NLRP3-caspase-1 pathway ( 102 ). Coincidentally, HRPs undergo caspase-1-dependent pyroptosis after treatment with advanced glycation end product modified bovine serum albumin (AGE-BSA), which often appears in the diabetic environment ( 128 ). LncRNA myocardial infarction-associated transcript (MIAT) regulates caspase-1 expression by sponging miR-342–3p, ultimately resulting in the pyroptosis of HRPs treated with AGE-BSA ( 128 ).…”

Section: Effect Of Pyroptosis On the Retinal Nvu In Drmentioning

confidence: 99%

“…Coincidentally, HRPs undergo caspase-1-dependent pyroptosis after treatment with advanced glycation end product modified bovine serum albumin (AGE-BSA), which often appears in the diabetic environment ( 128 ). LncRNA myocardial infarction-associated transcript (MIAT) regulates caspase-1 expression by sponging miR-342–3p, ultimately resulting in the pyroptosis of HRPs treated with AGE-BSA ( 128 ). Notably, the authors used immunofluorescence staining and observed that AGE-BSA-induced HRPs exhibited phenotypic features of pyroptosis, including pyknosis, cell swelling, and hyperpermeability in the plasma membrane ( 128 ).…”

Section: Effect Of Pyroptosis On the Retinal Nvu In Drmentioning

confidence: 99%

Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Meng

et al. 2021

Front. Immunol.

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Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type of inflammatory cell death mediated by gasdermin D (GSDMD), NOD-like receptors and inflammatory caspases that promote interleukin-1β (IL-1β) and IL-18 release. In addition, the retinal neurovascular unit (NVU) is the functional basis of the retina. Recent studies have shown that pyroptosis may participate in the destruction of retinal NVU cells in simulated hyperglycemic DR environments. In this review, we will clarify the importance of pyroptosis in the retinal NVU during the development of DR.

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“…Moreover, high glucose significantly induces elevated levels of caspase-1 and IL-1β in Müller cells and microglial cells during DR ( Feenstra et al, 2013 ). A large number of studies report the phenomenon of pyroptosis in endothelial cells ( Gu et al, 2019 ) and pericytes ( Gan et al, 2020 ; Yu et al, 2021 ) during DR development. The pyroptosis of microglial cells or neuron in early stage will create a inflammatory microenvironment of the neurovascular unit, which may be the main inducer for the pyroptosis in endothelial cells and pericytes.…”

Section: Pyroptosis In Diabetic Neuropathymentioning

confidence: 99%

Advances in the Relationship Between Pyroptosis and Diabetic Neuropathy

Cai

Zhao

et al. 2021

Front. Cell Dev. Biol.

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Pyroptosis is a novel programmed cell death process that promotes the release of interleukin-1β (IL-1β) and interleukin-18 (IL-18) by activating inflammasomes and gasdermin D (GSDMD), leading to cell swelling and rupture. Pyroptosis is involved in the regulation of the occurrence and development of cardiovascular and cerebrovascular diseases, tumors, and nerve injury. Diabetes is a metabolic disorder characterized by long-term hyperglycemia, insulin resistance, and chronic inflammation. The people have paid more and more attention to the relationship between pyroptosis, diabetes, and its complications, especially its important regulatory significance in diabetic neurological diseases, such as diabetic encephalopathy (DE) and diabetic peripheral neuropathy (DPN). This article will give an in-depth overview of the relationship between pyroptosis, diabetes, and its related neuropathy, and discuss the regulatory pathway and significance of pyroptosis in diabetes-associated neuropathy.

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Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342–3p targeting of CASP1 in diabetic retinopathy

Cited by 54 publications

References 35 publications

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Advances in the Relationship Between Pyroptosis and Diabetic Neuropathy

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