Long noncoding RNA RMRP promotes proliferation and invasion via targeting miR‐1‐3p in non–small‐cell lung cancer

Wang, Yi; Luo, Xiang; Liu, Yang; Han, Guorong; Sun, Dapeng

doi:10.1002/jcb.28779

Cited by 39 publications

(22 citation statements)

References 36 publications

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“…As for miR-1-3p, increasing studies have focused on miR-1-3p in many cancers but only few have been conducted on STAD. For instance, the expression level of miR-1-3p was suppressed by a long noncoding RNA component of mitochondrial RNA-processing endoribonuclease, which induced the proliferation, migration, and invasion of non-small-cell lung cancer cells [ 24 ]. Additionally, miR-1-3p inhibited the proliferation of hepatocellular carcinoma cells by regulating SRY- (sex-determining region Y-) box 9 [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Use of a Four-miRNA Panel as a Biomarker for the Diagnosis of Stomach Adenocarcinoma

Chen

Peng

et al. 2020

Disease Markers

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Background. MicroRNAs (miRNAs) have been applied to cancer diagnosis taking into account their role in tumorigenesis. The main purpose of our study was to confirm the possibility of using miRNAs as noninvasive biomarkers for stomach adenocarcinoma (STAD) diagnosis. Methods. A total of 246 participants (130 STAD patients and 116 healthy controls (HCs)) were enrolled in this 3-phase study. Five STAD pools and 3 HC pools (with 4 participants in each pool) were used for the screening of the 28 miRNAs using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The training phase (30 STAD patients vs. 24 HCs) and validation phase (80 STAD patients vs. 80 HCs) were used to further verify the identity of these miRNAs. Kaplan–Meier survival analysis and bioinformatics analysis were also used. Results. The expression levels of miR-125b-5p and miR-196a-5p were upregulated in STAD serum, compared with the HCs, while miR-1-3p and miR-149-5p showed the opposite result. A four-serum miRNA panel was constructed, and the area under the receiver operating characteristic curve (AUC) was found to be 0.892 (95% CI: 0.834 to 0.936, sensitivity = 86.25 % , specificity = 78.75 % ). Only miR-125b-5p expression showed a significant difference between STAD patients and NCs in the survival analysis. The neurotrophin signaling pathway was associated with 4 miRNAs identified in STAD patients. Conclusion. The four-serum miRNA panel has great potential to be used as a noninvasive biomarker for STAD diagnosis.

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Section: Discussionmentioning

confidence: 99%

Use of a Four-miRNA Panel as a Biomarker for the Diagnosis of Stomach Adenocarcinoma

Chen

Peng

et al. 2020

Disease Markers

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“…RMRP RNA acted as a sponge for miR-34a-5p, leading to up-regulation of c-MYC, a target of miR-34a-5p (Xiao et al 2019). Furthermore, in nonsmall cell lung cancer cells, RMRP overexpression impacted ANXA2 level through binding and repression of miR-1-3p (Wang et al 2019b), and in papillary thyroid cancer cells, it led to increased MAPK1 levels through binding and repression of miR-675 (Wang et al 2019a). Unlike decreased RMRP function, increased levels of RMRP thus favor cell proliferation and can enhance expression of various mRNAs through sequestration of various microRNAs.…”

Section: Rmrp In Cancermentioning

confidence: 99%

RNA polymerase III transcription as a disease factor

Yeganeh

Hernandez

2020

Genes Dev.

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RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in eukaryotic cells, whose RNA products have well-defined functions in translation and other biological processes for some, and functions that remain to be defined for others. For all of them, however, new functions are being described. For example, Pol III products have been reported to regulate certain proteins such as protein kinase R (PKR) by direct association, to constitute the source of very short RNAs with regulatory roles in gene expression, or to control microRNA levels by sequestration. Consistent with these many functions, deregulation of Pol III transcribed genes is associated with a large variety of human disorders. Here we review different human diseases that have been linked to defects in the Pol III transcription apparatus or to Pol III products imbalance and discuss the possible underlying mechanisms.

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“…Then, miRNA-mRNA regulatory network revealed that miR-1-3p, miR-10a-3p, miR-10a-5p and miR-133a-3p had rich external connections, while miR-99b-5p have few external connections. miR-1-3p acted as a tumor suppressor in acute myeloid leukemia [28], bladder cancer [29], non-small-cell lung cancer [30], hepatocellular carcinoma [31] and so on. Zhi Y et al reported that high miR-10a-5p expression was associated with poorer overall survival of AML patients [32].…”

Section: Discussionmentioning

confidence: 99%

Identification of the key genes and microRNAs in adult acute myeloid leukemia with FLT3 mutation by bioinformatics analysis

Chen¹,

Chen²,

Zhu³

et al. 2020

Int. J. Med. Sci.

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Background: Associated with poor prognosis, FMS-like tyrosine kinase 3 (FLT3) mutation appeared frequently in acute myeloid leukemia (AML). Herein, we aimed to identify the key genes and miRNAs involved in adult AML with FLT3 mutation and find possible therapeutic targets for improving treatment. Materials: Gene and miRNA expression data and survival profiles were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. EdgeR of R platform was applied to identify the differentially expressed genes and miRNAs (DEGs, DE-miRNAs). Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by Metascape and DAVID. And protein-protein interaction network, miRNA-mRNA regulatory network and clustering modules analyses were performed by STRING database and Cytoscape software. Results: Survival analysis showed FLT3 mutation led to adverse outcome in AML. 24 DE-miRNAs (6 upregulated, 18 downregulated) and 250 DEGs (54 upregulated, 196 downregulated) were identified. Five miRNAs had prognostic value and the results matched their expression levels (miR-1-3p, miR-10a-3p, miR-10a-5p, miR-133a-3p and miR-99b-5p). GO analysis showed DEGs were enriched in skeletal system development, blood vessel development, cartilage development, tissue morphogenesis, cartilage morphogenesis, cell morphogenesis involved in differentiation, response to growth factor, cell-substrate adhesion and so on. The KEGG analysis showed DEGs were enriched in PI3K-Akt signaling pathway, ECM-receptor interaction and focal adhesion. Seven genes (LAMC1, COL3A1, APOB, COL1A2, APP, SPP1 and FSTL1) were simultaneously identified by hub gene analysis and module analysis. SLC14A1, ARHGAP5 and PIK3CA, the target genes of miR-10a-3p, resulted in poor prognosis. Conclusion: Our study successfully identified molecular markers, processes and pathways affected by FLT3 mutation in AML. Furthermore, miR-10a-3p, a novel oncogene, might involve in the development of FLT3 mutation adult AML by targeting SLC14A1, ARHGAP5 and PIK3CA.

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Long noncoding RNA RMRP promotes proliferation and invasion via targeting miR‐1‐3p in non–small‐cell lung cancer

Cited by 39 publications

References 36 publications

Use of a Four-miRNA Panel as a Biomarker for the Diagnosis of Stomach Adenocarcinoma

Use of a Four-miRNA Panel as a Biomarker for the Diagnosis of Stomach Adenocarcinoma

RNA polymerase III transcription as a disease factor

Identification of the key genes and microRNAs in adult acute myeloid leukemia with FLT3 mutation by bioinformatics analysis

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