Long noncoding RNA SNHG12 facilitates the tumorigenesis of glioma through miR-101-3p/FOXP1 axis

Sun, Yuchen; Liu, Jian; Chu, Liangzhao; Yang, Wenxiu; Liu, Hongjiang; Li, Chen; Yang, Jianhui

doi:10.1016/j.gene.2018.08.034

Cited by 35 publications

(32 citation statements)

References 27 publications

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“…In glioma, SNHG12 targeting of miR-101-2 leads to enhanced cell growth (134), malignant progression via TDP43 (TAR DNAbinding protein 43) (135), and enhanced proliferation/migration capacity due to the association with the Hu antigen R (136).…”

Section: Small Nucleolar Rna Host Gene 12 (Snhg12)mentioning

confidence: 99%

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

et al. 2020

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The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literature research, we also found that silencing of SNHGs through small interfering RNAs or short hairpin RNAs is very effective in both in vitro and in vivo experiments by lowering the aggressiveness of solid cancers. The knockdown of SNHG as a new cancer therapeutic option should be investigated more in the future.

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Section: Small Nucleolar Rna Host Gene 12 (Snhg12)mentioning

confidence: 99%

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

et al. 2020

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“…Then, the statistical heterogeneity of the results was analyzed by using a random effect model (chi square test, P < 0.1). Otherwise, we used a xed effect model (chi square test, P > 0.1) [24,27] . The results of the meta-analysis are displayed on the forest map.…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that lncRNAs can act as molecular scaffolds, sponges or coactivators in tumor scaffolds by interacting with DNA, RNA or proteins [5,31,32] . At present, increasing evidence has shown that the abnormally high expression of SNHG12 plays a carcinogenic role in various malignant tumors [10][11][12][13][14][15][16][17][18][19][26][27][28][29] .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in lung cancer, this molecule can inhibit metastasis and epithelial-mesenchymal transition when inhibited [12] . Furthermore, increased SNHG12 not only regulates malignant behavior by activating oncogenes (AMOT, HuR slug/ZEB2) [12,33,34] , signaling pathways (MAPK/Slug, wnt/β-catenin, and Notch signaling pathway) [10,11,29,30,35] and the microRNA-gene axis (miR-125b/STAT3 and miR-101-3p/FOXP1) [27,31,36] but also enhances chemoresistance of tumor cells [31,32,37] . SNHG12 is negative regulation miR-195-5p, miR-320, miR-129, miR-193a-3p, microRNA-199a/b-5p and miR-424-5 [11,14,15,17,26] .…”

Section: Discussionmentioning

confidence: 99%

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Long Noncoding RNA SNHG12 is a Potential Diagnostic and Prognostic Biomarker in Various Tumors

Wang

Jiang

Zhang³

et al. 2020

Preprint

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Background. Tumors are the second most common cause of death in humans worldwide, second only to cardiovascular and cerebrovascular diseases. Although methods and techniques for the treatment of tumors continue to improve, the effect is not satisfactory. These may lack effective therapeutic targets. This study aimed to evaluate the value of SNHG12 as a biomarker in the prognosis and clinical characteristics of various cancer patients.Methods. We analyzed SNHG12 expression and plotted the survival curves of all cancer samples in the TCGA database using the GEPIA tool. Then, we searched for eligible papers up to April 1, 2019 in databases. Next, the data were extracted from studies examining SNHG12 expression, overall survival and clinicopathological features in patients with malignant tumors. We used Review Manager 5.3 and Stata 15 software to analyze the statistical data.Results. In the TCGA database, abnormally high expression of SNHG12 in tumor samples indicates that the patient has a poor prognosis. Results of meta-analysis is that SNHG12 high expression is related to low overall survival (HR=2.72, 95% CI=1.95-3.8, P<0.00001), high tumor stage (OR=3.94, 95% CI=2.80-5.53, P<0.00001), high grade (OR=2.04, 95% CI=1.18-3.51, P=0.01), distant metastasis (OR=2.20, 95% CI=1.40-3.46, P=0.0006), tumor size (OR=2.79, 95% CI=1.89-4.14, P<0.00001) and lymph node metastasis (OR=2.66, 95%CI=1.65-4.29, P<0.0001).Conclusions. Our study confirmed that the high expression level of SNHG12 is closely related to the clinicopathological characteristics and prognosis of patients and is a new predictive biomarker for various cancer patients.

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“…Thus, ROS1-circENTPD7 feedback contributes to glioma pathogenesis. Although miR-101-3p had been reported in glioblastoma [17][18][19], whether miR-101-3p regulates cell growth in vivo remains unclear. We found that miR-101-3p not only inhibited cell growth in vivo (Additional file 2: Fig.…”

Section: Ros1 Serves As the Target Of Circentpd7/mir-101-3pmentioning

confidence: 99%

A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1

et al. 2020

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Background: Circular RNAs (circRNAs) are identified to play an important role in many human cancers, such as glioblastoma. However, the potential mechanisms underlying the relationship between circRNAs and glioblastoma pathogenesis are still elusive. This study is designed to investigate the role of circRNAs in glioblastoma progression. Methods:The present study is designed to investigate the mechanism by which circRNAs involves in glioblastoma pathogenesis. By using circRNAs microarray, we detected the dysregulated circRNAs and identified an up-regulated circRNA, circENTPD7 in glioblastoma tissues. Cell proliferation was measured using a CCK-8 assay. Cell clone formation ability was assessed with a clone formation test. We used the bioinformatics website to predict circRNA-miRNA and miRNA-mRNA interactions. CircRNA-miRNA interaction was confirmed by dual-luciferase reporter assays and RNA-RNA pulldown assay.Results: circENTPD7 (hsa_circ_0019421) was upregulated in glioblastoma tissues. Kaplan-Meier survival analysis indicated that glioblastoma patients had a poor overall survival when circENTPD7 expression levels were high. Knockdown of circENTPD7 inhibited the motility and proliferation of glioblastoma cells. Moreover, we demonstrated that circENTPD7 acted as a sponge of miR-101-3p to regulate the expression of ROS1 further promoted the proliferation and motility of glioblastoma cells. Conclusions:Taken together, these findings indicate that circRNA circENTPD7 promotes glioblastoma cell proliferation and motility by regulating miR-101-3p/ROS1.

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Long noncoding RNA SNHG12 facilitates the tumorigenesis of glioma through miR-101-3p/FOXP1 axis

Cited by 35 publications

References 27 publications

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

Long Noncoding RNA SNHG12 is a Potential Diagnostic and Prognostic Biomarker in Various Tumors

A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1

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