Long noncoding RNA SOX2OT promotes the proliferation of pancreatic cancer by binding to FUS

Chen, Lei; Zhang, Jingjing; Chen, Qun; Ge, Wei; Meng, Long; Huang, Xumin; Shen, Peng; Hao, Yuan; Shi, Guodong; Miao, Yi; Jiang, Kuirong

doi:10.1002/ijc.32827

Cited by 27 publications

(23 citation statements)

References 34 publications

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“…Furthermore, we confirmed thatLINC01419 and EZH2 interact with FUS, an oncogenesis-associated RBP involved in transcriptional regulation and RNA processing [19]. We reported that LINC01419 stabilizes EZH2-mRNA through a FUS-mediated mechanism, this is similar to our previous findings [20]. The lncRNAs can also function through the ceRNA network [21].…”

Section: Agingsupporting

confidence: 90%

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK

Zhang¹,

Chen

et al. 2020

Aging

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This study aims to investigate the biological role of LINC01419 and the underlying mechanism in HCC. RESULTS LINC01419 expression level is elevated in HCC tissues and is associated with a malignant phenotype In investigating the role of lncRNAs in HCC progression, the lncRNA expression profile was analyzed in HCC samples and non-HCC liver samples. The samples were obtained from TCGA datasets via circlncRNAnet (http://app.cgu.edu.tw/circlnc/) and TANRIC (http://ibl.mdanderson.org/tanric/_design/ basic/index.html). Several abnormal lncRNAs were detected and showed significant statistical differences. This study focused on LINC01419 because it showed the most significant difference (Figure 1A, Supplementary Figure 1A). The LINC01419 expression level was higher in HCC cell lines when compared to LO2 (normal liver cell line), (Figure 1B). To confirm whether

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Section: Agingsupporting

confidence: 90%

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK

Zhang¹,

Chen

et al. 2020

Aging

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“…Long non-coding RNAs (lncRNAs) exert an essential role in the occurrence and progression of tumors [3,4], mainly in cancer proliferation, metastasis, and other biological functions associated with tumorigenesis [5,6]. In PC, abnormal expression and dysfunction of lncRNAs are shown to be associated with rapid progression of cancer and distant metastasis [7,8].…”

Section: Introductionmentioning

confidence: 99%

LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis

Zhang

Zhu

et al. 2020

J Exp Clin Cancer Res

132

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Background: Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-AS1 in pancreatic cancer are largely unclear. Methods: Quantitative reverse transcription PCR (qRT-PCR) is used to examine the expression of PMSB8-AS1 in PC tissues and PC cell lines. The effect of PMSB8-AS1 on the proliferation of PC cells was detected using CCK8 assay, colony assay, and flow cytometry. The effect of PMSB8-AS1 on the migration and invasion of pancreatic cancer cells was detected using a wound-healing assay and transwell migration assay. Bioinformatic analysis, double luciferase reporting assay, western blot, and rescue experiments were used to detect the regulatory relationship between PMSB8-AS1, miR-382-3p, STAT1, and PD-L1. Results: PMSB8-AS1 expression was upregulated in PC tissues and cell lines and positively associated with the worst survival in patients with PC. The in vitro and in vivo assays demonstrated that overexpression of PMSB8-AS1 significantly promoted pancreatic cancer cell proliferation, migration, and invasion, whereas knockdown of PMSB8-AS1 suppressed cell proliferation, migration, invasion, and EMT, and decreased apoptosis of PC cells. Besides, PMSB8-AS1 directly bound to miR-382-3p downregulated its expression. Besides, PMSB8-AS1 reversed the effect of miR-382-3p on the growth and metastasis of PC cells, which might be targeted on STAT1. Furthermore, STAT1 is the transcriptional factor that activates the expression of PD-L1. Conclusion: lncRNA PMSB8-AS1 promotes pancreatic cancer progression via STAT1 by sponging miR-382-3p involving regulation PD-L1.

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“…A search using key words of (lncRNA or (long noncoding RNA)) and (pancreatic cancer)" in PubMed on July 28, 2020 yielded 589 publications, with the most relevant one dating back in 2011 [14]. Through different pathways, most lncRNAs have been reported to promote the proliferation of pancreatic cancer [15,16].…”

Section: Discussionmentioning

confidence: 99%

The role of long noncoding RNA AL161431.1 in the development and progression of pancreatic cancer

Fan

et al. 2020

Preprint

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Background: Pancreatic cancer is known for its notorious fast progression and poor prognosis. Various long noncoding RNAs (lncRNAs) have been shown to be involved in the pathogenesis processes of pancreatic cancer.Methods: We first identified lncRNA AL161431.1 through bioinformatic analysis. Then, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by in vitro and in vivo experiments, including qRT-PCR, Western blot, immunofluorescence and immunohistochemistry assays, and flow cytometry, in BxPC-3 and SW1990 cells, as well as clinical samples. Results: We found that lncRNA AL161431.1 was highly expressed in patients with pancreatic cancer. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of the epithelial mesenchymal transition pathway.Conclusions: LncRNA AL161431.1 is involved in the progression of pancreatic cancer through its promotion of the epithelial mesenchymal transition pathway.

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Long noncoding RNA SOX2OT promotes the proliferation of pancreatic cancer by binding to FUS

Cited by 27 publications

References 34 publications

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK

LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis

The role of long noncoding RNA AL161431.1 in the development and progression of pancreatic cancer

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