Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer

Abstract

Gastric cancer (Gc) is a leading cause of cancer-associated mortality worldwide. Previous studies demonstrated that long noncoding rnas (lncrnas) may be dysregulated in Gc and may serve important roles in cancer progression. The present study aimed to investigate the role of the novel lncrna stomach cancer-associated transcript 16 (STcaT16; assembly Gene id G038291) in the development and progression of Gc. The present data suggested that the expression level of STcaT16 was decreased in Gc tissues. The expression level of STCAT16 was identified to be associated with lymph node and tumour node metastasis stages. Furthermore, the expression level of STcaT16 was identified to be significantly associated with poor survival and prognosis. Knockdown of STcaT16 promoted proliferation, colony formation, migration and invasion of BGc-823 cells. in contrast, these features were suppressed in aGS cells following overexpression of STcaT16. In vivo, tumour growth was significantly decreased following STCAT16 overexpression. collectively, the present data suggested that the lncrna STcaT16 may act as a tumour suppressor and may inhibit Gc tumour cell growth and migration. additionally, the decreased expression level of STCAT16 was identified to be associated with poor prognosis in patients with Gc.

TMPO-AS1 promotes cell proliferation of thyroid cancer via sponging miR-498 to modulate TMPO

“…LncRNAs have been reported to impact biological processes like cell proliferation, apoptosis and metastasis via sponging miRNAs to modulate proteins. For example, lncRNA STCAT16 suppresses cell growth in gastric cancer [8]. LncRNA PEG10 sponges miR-134 to exert its oncogenic function in bladder cancer [9].…”

RETRACTED ARTICLE: Long noncoding RNA LINC00339 promotes the oncogenicity of gastric cancer by regulating SRY-box 9 expression via sponging of microRNA-539

“…Dysregulation of lncRNA in cancer was widely acknowledged in recent years. For instance, lncRNAs GASL1 [11], STCAT16 [12], and STXBP5-AS1 [13] are downregulated in gastric cancer and exert tumor-suppressive actions; on the contrary, ADPGK-AS1 [14], TTN-AS1 [15], and LINC00460 [16] are upregulated in gastric cancer and play an oncogenic role. Therefore, identifying gastric cancer-related lncRNAs and elucidating their functions in cancer progression may be useful for the identification of diagnostic biomarkers and therapeutic targets in this disease.…”

Clinicopathological and prognostic value of long noncoding RNA SNHG7 in cancers: a meta-analysis and bioinformatics

“…For example, highly expressed lncHOTAIR could regulate cancer differentiation, distant metastasis in colorectal cancer tissues and closely related to TNM stage [ 10 ]. It has been reported that overexpressed LncSTCAT16 is a potent molecular target for inhibition of the cell proliferation and invasion in gastric cancer [ 11 ]. The up-regulation of LncPANDAR which promotes cell proliferation has been proved to related to poor prognosis of cervical cancer [ 12 ].…”