Long noncoding RNA XIST modulates microRNA-135/CREB1 axis to influence osteogenic differentiation of osteoblast-like cells in mice with tibial fracture healing

Prognostic and therapeutic potential of microRNAs for fracture healing processes and non‐union fractures: A systematic review

“…Eleven studies performed a screening in patients with non‐union fracture compared to uneventful healing. 53 , 125 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 Blood samples were analysed in n = 2 131 , 137 studies and callus tissue in n = 9 53 , 74 , 125 , 130 , 132 , 133 , 134 , 135 , 136 , 138 studies (Table 2 ). The identified miRNAs during screening were then validated in further experiments.…”

“…Out of 14 studies that implemented a fracture model, eight fracture models were performed in rats, 129 , 132 , 138 , 139 , 140 , 142 , 143 , 144 and six were performed in mice 130 , 131 , 135 , 141 , 145 , 146 with C57BL/6J being the most common strain. 130 , 131 , 136 , 145 Two studies did not indicate the mouse strain used. 135 , 141 …”

“…Fourteen out of 19 studies performed an in vitro experiment to validate clinical or in vivo findings. Five of these studies 130 , 133 , 134 , 136 , 145 used osteoblasts, while six studies 53 , 131 , 132 , 135 , 138 , 143 used (B)MSCs with cells cultured under osteogenic conditions. Transfection of MSCs with miRNA‐mimics or ‐inhibitors was also performed.…”

Role of mechano-sensitive non-coding RNAs in bone remodeling of orthodontic tooth movement: recent advances

“…Yu et al [110] reported that XIST negatively regulates nicotinamide N-methyltransferase by sponging miR-29b-3p to restrict the osteogenic differentiation of BMSCs. Knockdown of XIST induces the differentiation of osteoblast-like cells via regulation of the miR-135/CREB1/TNF-α/RANKL [111] and miR-375-3p/ AKT/mTOR [112] axis, representing an attractive therapeutic strategy to accelerate bone remodeling.…”

“…XIST miR-214-3p Unknown Inhibit osteogenic differentiation of PDLSCs [109] miR-29b-3p RUNX2 Inhibit OB differentiation [110] miR-135 RANKL Inhibit OB differentiation [111] miR-375-3p AKT/mTOR Inhibit OB differentiation [112] DANCR Unknown WNT Promote osteogenic differentiation of PDLSC [113] Unknown EZH2↓, Runx2↑ Increase OB proliferation and decrease OB apoptosis [114] miR-758 Notch2 Suppress osteogenic differentiation of PDLSC [115] Jagged1 Notch Facilitate osteoclast formation and root resorption [116] TUG1 miR-222-3p Smad2/7 Facilitate osteogenic differentiation of PDLSC [117] Unknown Wnt/β-catenin Promote OB proliferation and differentiation [118] miR-545-3p CNR2 Promote OB proliferation and differentiation [119] miR-34a FGFR1 Promote OB proliferation and inhibit apoptosis [61] Unknown MafB Stimulate osteoclast formation [120] PCAT1 miR-106a-5p BMP2 Promote osteogenic differentiation of PDLSC [121] H19 miR-675 TGF-β1/Smad3/HDAC Promote osteogenic differentiation of hMSC [122] miR-22, -141 Wnt/β-catenin Potentiate osteogenesis [123] miR-138 FAK Unknown [124] miR-188 LCoR Promote osteogenic differentiation of mBMSC [125] miR-19b-3p Unknown Promote cell proliferation and osteogenic differentiation of BMSCs [126] miR-675 APC Promote osteogenic differentiation of BMSC [127] miR-149 SDF-1 Stimulates osteogenic differentiation of BMSC [128] miR-185-5p IGF1 Promote matrix mineralization [129] miR-140-5p SATB2 Promote osteogenic differentiation of BMSC [130] miR-467 HoxA10 Promote osteogenic differentiation of BMSC [131] miR-106 Angpt1 Promote osteogenesis and angiogenesis [132] miR-625-5p Wnt/β-catenin Promote BMSC proliferation and osteogenic differentiation [133] miR-541-3p Wnt/β-catenin Promote osteogenic differentiation of BMSC [134] miR-532-3p SIRT1 Promote osteogenic differentiation of BMSC [135] miR Wu [117] revealed that TUG1 accelerates the osteogenic differentiation by sponging m...…”