Long noncoding RNAs are novel potential prognostic biomarkers for esophageal squamous cell carcinoma: an overview

Deng, Han‐Yu; Wang, Yun-Cang; Ni, Peng-Zhi; Lin, Yi‐Dan; Chen, Long-Qi

doi:10.21037/jtd.2016.07.01

Cited by 31 publications

(32 citation statements)

References 51 publications

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“…It is essential to investigate tumor-associated lncRNAs in order to recognize their complex intermolecular interactions in carcinogenesis, specifically esophageal cancer. Rapid growth and high incidence of regional and distant metastasis of aggressive tumors contributes to the poor prognosis of ESCC patients, despite rapid advances in the diagnosis and treatment of the disease (23). A clear understanding of the critical mechanisms involved in the genesis and development of ESCC is required in order to improve the survival rates of ESCC patients.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma

Wang

Yang

et al. 2018

Mol Med Report

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Despite being one of the most prevalent and fatal types of cancer worldwide, the biological details of esophageal squamous cell carcinoma (ESCC) remain unknown. Recent studies have demonstrated the crucial roles of long non-coding RNAs (lncRNAs) in diverse biological processes including cancer initiation, progression and metastasis. The aim of the present study was to assess the expression profile of distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) in ESCC tissues and its contributions to ESCC cell proliferation, apoptosis and invasion. The expression of DLX6-AS1 in a series of ESCC samples and paired adjacent noncancerous tissues was evaluated by reverse transcription-quantitative polymerase chain reaction. Cell proliferation, apoptosis, wound healing and Transwell invasion assays were performed to evaluate the roles of DLX6-AS1 in the ESCC cell lines EC109 and KYSE30 transfected with DLX6-AS1 small interfering RNA (siRNA). Compared with the paired adjacent noncancerous tissues, DLX6-AS1 expression was upregulated in the ESCC tissues and significantly associated with differentiation status, Tumor-Node-Metastasis stage, distant metastasis, and lymph node metastasis. Knockdown of DLX6-AS1 significantly suppressed cell proliferation, invasion and migration abilities, and enhanced the apoptotic rate in the two ESCC cell lines. Furthermore, western blot assays revealed that silencing DLX6-AS1 partly influenced the epithelial-mesenchymal transition process in ESCC cells. These results imply that the oncogenic function of DLX6-AS1 may be a novel candidate target for treating human ESCC.

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Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma

Wang

Yang

et al. 2018

Mol Med Report

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“…To understand the role of ncRNAs in ESCC progression, numerous investigations on ncRNAs (mainly miRNAs and lncRNAs) in ESCC have been reported [7,8,[29][30][31]. Many studies on the regulation of circRNAs in ESCC are in their early stages.…”

Section: Role Of Non-coding Rnas In Escc Progressionmentioning

confidence: 99%

“…Long ncRNAs can function as gene regulators by interacting with DNA (e.g., as promoters), RNA, or proteins [142]. Accumulating evidence has proposed that lncRNAs play a significant role in the biological development of ESCC, such as in the regulation of cell proliferation and apoptosis [7,143]. For instance, lncRNA small nucleolar host gene 1 (SNHG1), SNHG6, and SNHG16 have been reported to promote ESCC cell proliferation [74][75][76][77][78].…”

Section: Non-coding Rnas Regulate Cell Proliferation and Apoptosis Dumentioning

confidence: 99%

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Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma

Feng

Zhang

Yao

et al. 2019

IJMS

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Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules involved in the development of many human cancers, including ESCC. Recently, several ncRNAs have been detected as oncogenes or tumor suppressors in ESCC progression. These ncRNAs influence the expression of specific genes or their associated signaling pathways. Moreover, interactions of ncRNAs are evident in ESCC, as miRNAs regulate the expression of lncRNAs, and further, lncRNAs and circRNAs function as miRNA sponges to compete with the endogenous RNAs. Here, we discuss and summarize the findings of recent investigations into the role of ncRNAs (miRNAs, lncRNAs, and circRNAs) in the development and progression of ESCC and how their interactions regulate ESCC development.

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“…LncRNA-Low Expression in Tumor (lncRNA-LET, NCBI number AK055007), a recently identified lncRNA located at chromosome 15q24.1, has been demonstrated to be downregulated in several types of cancer, including hepatocellular carcinomas [ 12 ], esophageal squamous cell carcinoma [ 13 ] and gallbladder cancer [ 14 ]. However, the expression and function of lncRNA-LET in NSCLC are still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of long non-coding RNA LET predicts poor prognosis and increases Notch signaling in non-small cell lung cancer

Zhao

et al. 2017

Oncotarget

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Long non-coding RNAs (lncRNAs) have been found to be dysregulated in a variety of tumors. The lncRNA-Low Expression in Tumor (LET) is a recently identified lncRNA, but its expression pattern and biological significance in human non-small cell lung cancer (NSCLC) are still largely unknown. In this study, we found that lncRNA-LET was significantly downregulated in human NSCLC lung tissues and cell lines. Decreased lncRNA-LET expression was strongly associated with advanced tumor stages and poorer overall survival of NSCLC patients. Functionally, overexpression of lncRNA-LET in NSCLC H292 cells significantly suppressed cell proliferation, migration and invasion, and promoted cell cycle arrest and apoptosis, while knockdown of lncRNA-LET in NSCLC H1975 cells showed an opposite effect, pointing to a tumor-suppressive role for lncRNA-LET in NSCLC. Mechanistically, we demonstrated that lncRNA-LET overexpression significantly reduced the expression of Notch1 intracellular Domain (NICD1) in H292 cells while knockdown of lncRNA-LET increased NICD1 expression in H1975 cells. Similarly, NSCLC lung tissues with high levels of lncRNA-LET had lower NICD1 expression. Thus, our results provide a strong rationale for lncRNA-LET to be used as a prognostic indicator and a potent therapeutic target for NSCLC patients, and highlight a novel lncRNA-LET/Notch axis in regulating NSCLC cell fate and tumor progression.

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Long noncoding RNAs are novel potential prognostic biomarkers for esophageal squamous cell carcinoma: an overview

Cited by 31 publications

References 51 publications

Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma

Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma

Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma

Downregulation of long non-coding RNA LET predicts poor prognosis and increases Notch signaling in non-small cell lung cancer

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