Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

Conforti, FrancescaLuisa; Ruffo, Paola; Amicis, Francesca De; Giardina, Emiliano

doi:10.4103/1673-5374.358615

Cited by 28 publications

(11 citation statements)

References 102 publications

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“…Accumulating evidence has revealed the pivotal roles of lncRNAs in epigenetic regulation, acting as scaffolds for chromatin-modifying complexes or interacting with various epigenetic regulators to influence gene expression [ 135 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

Dogaru

Munteanu

2023

IJMS

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This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to elucidate the multifaceted ways in which H2S influences the epigenetic landscape and, subsequently, the progression of various neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease. H2S can modulate key components of the epigenetic machinery, such as DNA methylation, histone modifications, and non-coding RNAs, impacting gene expression and cellular functions relevant to neuronal survival, inflammation, and synaptic plasticity. We synthesize recent research that positions H2S as an essential player within this intricate network, with the potential to open new therapeutic avenues for these currently incurable conditions. Despite significant progress, there remains a considerable gap in our understanding of the precise molecular mechanisms and the potential therapeutic implications of modulating H2S levels or its downstream targets. We conclude by identifying future directions for research aimed at exploiting the therapeutic potential of H2S in neurodegenerative diseases.

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Section: Resultsmentioning

confidence: 99%

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

Dogaru

Munteanu

2023

IJMS

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“…In recent years, lncRNAs were particularly studied for their role in the regulation of transcription and translation in physiological conditions and disease. Since lncRNA are particularly expressed and conserved in the brain (Ponjavic et al, 2009;Chodroff et al, 2010;Barry, 2014;Yang et al, 2021;Kyzar et al, 2022), their role was investigated in the epigenetic adaption of gene expression in drug addiction, aging, neuroinflammation, brain injury, neurodegenerative and neurodevelopmental diseases (Wang et al, 2018;Srivastava et al, 2021;Sivagurunathan et al, 2022;Yang K. et al, 2022;Mazzeo et al, 2023;Ruffo et al, 2023;Sherazi et al, 2023). The expression rate of lncRNAs is epigenetically modulated.…”

Section: Lncrna In α-Synucleinopathiesmentioning

confidence: 99%

Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson’s disease and synucleinopathies

Meccariello,

Bellenchi,

Pulcrano

et al. 2024

Front. Cell. Neurosci.

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Over the last few decades, emerging evidence suggests that non-coding RNAs (ncRNAs) including long-non-coding RNA (lncRNA), microRNA (miRNA) and circular-RNA (circRNA) contribute to the molecular events underlying progressive neuronal degeneration, and a plethora of ncRNAs have been identified significantly misregulated in many neurodegenerative diseases, including Parkinson’s disease and synucleinopathy. Although a direct link between neuropathology and causative candidates has not been clearly established in many cases, the contribution of ncRNAs to the molecular processes leading to cellular dysfunction observed in neurodegenerative diseases has been addressed, suggesting that they may play a role in the pathophysiology of these diseases. Aim of the present Review is to overview and discuss recent literature focused on the role of RNA-based mechanisms involved in different aspects of neuronal pathology in Parkinson’s disease and synucleinopathy models.

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“…Among mRNA modifications, an important group is represented by a set of RNA nucleotide modifications, together with their “readers”, that somehow recall the epigenetic DNA modifications (these aspects are probably, again, remnants of the primeval RNA world and have been termed “epitranscriptomics”) [ 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ]. One of the most represented mRNA modifications is m6A [ 147 , 148 ] that, when present in the mRNA 5′UTR, is even able to promote CAP-independent translation [ 141 ].…”

Section: Post-transcriptional Regulation and Synaptic Plasticity In T...mentioning

confidence: 99%

Role of Post-Transcriptional Regulation in Learning and Memory in Mammals

Di Liegro,

Schiera,

Schirò

et al. 2024

Genes

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After many decades, during which most molecular studies on the regulation of gene expression focused on transcriptional events, it was realized that post-transcriptional control was equally important in order to determine where and when specific proteins were to be synthesized. Translational regulation is of the most importance in the brain, where all the steps of mRNA maturation, transport to different regions of the cells and actual expression, in response to specific signals, constitute the molecular basis for neuronal plasticity and, as a consequence, for structural stabilization/modification of synapses; notably, these latter events are fundamental for the highest brain functions, such as learning and memory, and are characterized by long-term potentiation (LTP) of specific synapses. Here, we will discuss the molecular bases of these fundamental events by considering both the role of RNA-binding proteins (RBPs) and the effects of non-coding RNAs involved in controlling splicing, editing, stability and translation of mRNAs. Importantly, it has also been found that dysregulation of mRNA metabolism/localization is involved in many pathological conditions, arising either during brain development or in the adult nervous system.

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Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

Cited by 28 publications

References 102 publications

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson’s disease and synucleinopathies

Role of Post-Transcriptional Regulation in Learning and Memory in Mammals

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