2019
DOI: 10.3390/cancers11111638
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Long Noncoding RNAs in Acute Myeloid Leukemia: Functional Characterization and Clinical Relevance

Abstract: Acute Myeloid Leukemia (AML) is the most common form of leukemia in adults with an incidence of 4.3 per 100,000 cases per year. Historically, the identification of genetic alterations in AML focused on protein-coding genes to provide biomarkers and to understand the molecular complexity of AML. Despite these findings and because of the heterogeneity of this disease, questions as to the molecular mechanisms underlying AML development and progression remained unsolved. Recently, transcriptome-wide profiling appr… Show more

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Cited by 72 publications
(60 citation statements)
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References 164 publications
(190 reference statements)
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“…LncRNA plays a key role in many types of diseases, including cancer, cardiovascular disease, autoimmune diseases, and nervous system diseases (Yang et al, 2014). Recently, more and more studies suggest that lncRNA may be closely related to leukemia (Gourvest et al, 2019;Wu et al, 2019). However, the role of lncRNA in the proliferation and differentiation of leukemia cells induced by ATPR is unclear.…”
Section: Introductionmentioning
confidence: 99%
“…LncRNA plays a key role in many types of diseases, including cancer, cardiovascular disease, autoimmune diseases, and nervous system diseases (Yang et al, 2014). Recently, more and more studies suggest that lncRNA may be closely related to leukemia (Gourvest et al, 2019;Wu et al, 2019). However, the role of lncRNA in the proliferation and differentiation of leukemia cells induced by ATPR is unclear.…”
Section: Introductionmentioning
confidence: 99%
“…As a new noncoding RNA molecule, the abnormal expression of lncRNA in tumor tissue has attracted extensive attention of researchers [23,28]. Many studies have shown that lncRNA is likely to be a carcinogen gene [18,19] or a tumor suppressor gene [18] in the occurrence and development of tumors, and has increasingly become a biomarker of tumor diagnosis, treatment or prognosis, including AML [15,36]. Therefore, it is very important to identify more new cancer related lncRNAs and explore their biological functions and molecular mechanisms in order to explore new therapeutic methods of AML.…”
Section: Introductionmentioning
confidence: 99%
“…Based on the "Star Wars" movie, we will approach some ways of modifying the human person On pourrait même aller beaucoup plus vite en réalisant des modifications sur des gènes codant des ARN régulateurs de l'expression génique (microARN [miRNA] ou long ARN non codant). Sachant qu'un miARN ou un long ARN non codant [39] peut moduler l'expression de plusieurs centaines de gènes, les conséquences sur l'individu modifié devraient être bien plus importantes. Bien entendu de telles expériences ne sont pas autorisées à ce jour dans l'espèce humaine.…”
Section: Summary George Lucas: Prophet Of Transhumanism?unclassified