Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma

Xu, Yuming; Jiang, Erhui; Shao, Zhang; Shang, Zhengjun

doi:10.3389/fonc.2020.616717

Cited by 17 publications

(12 citation statements)

References 134 publications

(158 reference statements)

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“…Evidence also showed that different functional studies revealed the role of lncRNAs in oncogenesis, tumor-suppression, and chemoresistance as well as governing virtually every physiological cell process ( Figure 1 ). Abnormal lncRNAs are involved in many aspects of cancer cell processes including cell proliferation, apoptosis, invasion and metastasis [ 16 ], epithelial–mesenchymal transition (EMT), and drug resistance [ 17 ]. Moreover, lncRNAs even affect the outcome of patients such as lymph node metastasis, distal metastasis, and postoperative recurrence [ 18 ].…”

Section: Roles Of Lncrna In Osccmentioning

confidence: 99%

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Tang

Fang

Chen

et al. 2021

Cancers

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Oral squamous cell carcinoma (OSCC) is a type of malignancy with high mortality, leading to poor prognosis worldwide. However, the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Recently, the discovery and characterization of long non-coding RNAs (lncRNAs) have revealed their regulatory importance in OSCC. Abnormal expression of lncRNAs has been broadly implicated in the initiation and progress of tumors. In this review, we summarize the functions and molecular mechanisms regarding these lncRNAs in OSCC. In addition, we highlight the crosstalk between lncRNA and tumor microenvironment (TME), and discuss the potential applications of lncRNAs as diagnostic and prognostic tools and therapeutic targets in OSCC. Notably, we also discuss lncRNA-targeted therapeutic techniques including CRISPR-Cas9 as well as immune checkpoint therapies to target lncRNA and the PD-1/PD-L1 axis. Therefore, this review presents the future perspectives of lncRNAs in OSCC therapy, but more research is needed to allow the applications of these findings to the clinic.

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Section: Roles Of Lncrna In Osccmentioning

confidence: 99%

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Tang

Fang

Chen

et al. 2021

Cancers

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“…Oral cancer, which is associated with tissues in the mouth and throat, is a subtype of a larger group of cancers known as head and neck cancer. Although there are various forms of oral cancer, approximately 90% of the oral cancers are classified as squamous cell carcinomas because the mouth and throat are lined almost entirely with squamous cells (2,3) . Gingivobuccal complex cancer is a type of oral squamous cell cancer and has been reported to be the most common form of oral cancer in India among men and is quite predominant in countries where tobacco use is rampant.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, there is a need to properly identify and validate the expression of lncRNA in the gingivobuccal complex. Despite the presence of glaring evidence for lncRNA playing a critical role in the biological processes of human diseases, very few efforts have been made to identify their association with gingivobuccal cancer and assess their prognostic (2,5) . Furthermore the interest in the identification of lncRNA signatures in Gingivobuccal Squamous Cell Carcinoma (GBSCC) stems from the idea of identification of non-invasive biomarkers present in the saliva for early detection of oral cancer (6,7) .…”

Section: Introductionmentioning

confidence: 99%

A Transcriptomic Analysis to Identify Prevalent lncRNAs in Gingivobuccal Oral Cancer

Haldar¹,

Singh²

2023

IJST

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Objective: Gingivobuccal cancer is a subtype of oral cancer, prevalent in developing countries where the use of tobacco and Areca (betel) nut is rampant. This study aims to search through the publically available NCBI data to find comparisons between the normal and cancer-affected transcripts of RNA, which are molecules that copied the genetic information from DNA and that will be "read" as instructions to produce other molecules in the body. Using bioinformatic tools, we analyzed the variations in the transcripts and examined how they were correlated with other molecular processes in the body. We specifically investigated the role of "long noncoding RNAs (lncRNAs)" because it is speculated that they play an active role in the causality of cancer. Our analysis found a correlation of CTA-384D8.35 lncRNA with gingivobuccal cancer after analyzing the Hazard Ratio using the Cox Proportional-Hazard Model and is expected to pave the way for future studies. Methods: In this study, transcriptomic analysis was performed on a publicly available gingivobuccal cancer dataset obtained from NCBI. We developed a novel method for identification of annotated lncRNAs, which helped us select and correlate the lncRNA transcripts with the gingivobuccal cancer disease. Furthermore, the results were validated using the GEPIA2 tool for integrated analysis of co-lncRNA and GEPIA databases. Findings: From 24 RNA-Seq samples (12 normal samples and 12 tumor samples), a total of 16,065 potential lncRNA transcripts were recognized. From these 16,065 lncRNA transcripts, 1201 lncRNA transcripts were further filtered out based on a threshold adjusted p value of <0.01. We were able to for the first time identify these 1201 lncRNA transcripts, which were not annotated for gingivobuccal squamous cell carcinoma previously. Integrated analysis of co-lncRNA and GEPIA databases revealed that a total of 11 lncRNAs were upregulated, whereas 29 lncRNAs were downregulated. Furthermore, CTA-384D8.35 showed a significant correlation with disease-free survival time in HNSC. CTA-384D8.35 which is downregulated in gingivobuccal cancer has been correlated with tumor stage, metastasis, cancer status, clinical stage, and grade. Novelty: In this report we are for the first time correlating the CTA-384D8.35 lncRNA with the gingivobuccal cancer disease with the help of statistical and survival analysis. Furthermore, https://www.indjst.org/

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“…Over the last few years, the advent of high-throughput sequencing techniques has enabled identification of a continuously rising amount of dysregulated lncRNAs associated with oral cancer [ 17 , 18 ]. Among these transcripts, only a few have been thoroughly investigated for their mechanisms of action, whereas the functional details of most remain largely uncharacterized [ 19 , 20 , 21 , 22 ]. Within the long-standing intense debate about the functionality of most, if not all, of these lncRNAs, a precursor–product relationship between junk RNA and functional lncRNAs has recently been suggested, in which junk transcripts may provide the raw material for the evolution of diverse lncRNAs, through a non-adaptive mechanism [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises

Lei

Kung

Shih

2021

IJMS

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Oral cancer is one of the leading malignant tumors worldwide. Despite the advent of multidisciplinary approaches, the overall prognosis of patients with oral cancer is poor, mainly due to late diagnosis. There is an urgent need to develop valid biomarkers for early detection and effective therapies. Long non-coding RNAs (lncRNAs) are recognized as key elements of gene regulation, with pivotal roles in various physiological and pathological processes, including cancer. Over the past few years, an exponentially growing number of lncRNAs have been identified and linked to tumorigenesis and prognosis outcomes in oral cancer, illustrating their emerging roles in oral cancer progression and the associated signaling pathways. Herein, we aim to summarize the most recent advances made concerning oral cancer-associated lncRNA, and their expression, involvement, and potential clinical impact, reported to date, with a specific focus on the lncRNA-mediated molecular regulation in oncogenic signaling cascades and oral malignant progression, while exploring their potential, and challenges, for clinical applications as biomarkers or therapeutic targets for oral cancer.

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Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma

Cited by 17 publications

References 134 publications

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

A Transcriptomic Analysis to Identify Prevalent lncRNAs in Gingivobuccal Oral Cancer

Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises

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