2017
DOI: 10.1053/j.gastro.2017.04.046
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Long Noncoding RNAs in the Pathogenesis of Barrett’s Esophagus and Esophageal Carcinoma

Abstract: For many years, only a small fraction of the human genome was believed to regulate cell function and development. This protein-coding portion composed only 1% to 2% of 3 billion human DNA base pairs— the remaining sequence was classified as junk DNA. Subsequent research has revealed that most of the genome is transcribed into a broad array of noncoding RNAs, ranging in size from microRNA (20–23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides). These noncoding RNA classes have been shown t… Show more

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Cited by 50 publications
(43 citation statements)
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“…For their role in tumorigenesis, the aberrant expression of lncRNAs has an impact not only on cancer cell proliferation and metastasis and as prognostic factors [26] but also on EMT, tumor drug resistance, and cancer stem cells [27,28]. RP11-789C1.1 was identified initially in our previous study as a specific lncRNA that was significantly downregulated in gastric cancer tissues when compared with adjacent normal tissues [19].…”
Section: Discussionmentioning
confidence: 99%
“…For their role in tumorigenesis, the aberrant expression of lncRNAs has an impact not only on cancer cell proliferation and metastasis and as prognostic factors [26] but also on EMT, tumor drug resistance, and cancer stem cells [27,28]. RP11-789C1.1 was identified initially in our previous study as a specific lncRNA that was significantly downregulated in gastric cancer tissues when compared with adjacent normal tissues [19].…”
Section: Discussionmentioning
confidence: 99%
“…4 Long noncoding RNAs (lncRNAs) are loosely defined as RNAs that exceed 200 bases in length and have no apparent coding capacity. 4 Aberrant expression of lncRNAs has been associated with progression of various tumor types [5][6][7] and gastric carcinogenesis. 8,9 It is not clear how lncRNAs affect gastric tumor development and progression.…”
Section: Background and Aimsmentioning
confidence: 99%
“…Only 1% to 2% of the sequence of human genome sequence encode proteins, although more than 90% of them can be transcribed. 6 Noncoding RNAs (lncRNAs) play a major role in the expression of target genes. MicroRNAs (miRNAs), a large family of small noncoding endogenous RNAs containing 19 to 22 nucleotides, can decrease the transcription of messenger RNAs (mRNAs) and downregulate their expression by bind to their 3′UTR site.…”
Section: Introductionmentioning
confidence: 99%