Long noncoding RNAs: Novel insights into hepatocelluar carcinoma

He, Yong; Meng, Xiao‐Ming; Huang, Cheng; Wu, Boxi; Zhang, Lei; Lv, Xiongwen; Li, Jun

doi:10.1016/j.canlet.2013.10.021

Cited by 354 publications

(314 citation statements)

References 122 publications

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“…6,12 According to their size, the ncRNAs are divided into 2 groups: small ncRNAs (< 200 nt) and long ncRNAs (lncRNAs). It is increasingly recognized that lncRNAs constitute an important component in the regulation of gene expression and carcinogenesis.…”

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confidence: 99%

Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells

Jiang

Yan

et al. 2016

JNS

157

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M alignant gliomas are the most common type of primary malignant brain tumor, and more than half of all gliomas are glioblastomas (Grade IV astrocytoma), one of the most aggressive and lethal types of brain tumor. Glioblastoma cells easily infiltrate into the normal cerebral cortex, ultimately resulting in the death of the patient. Well-defined risk factors for glioblastoma include radiation exposure and certain genetic syndromes. 21Several molecular and genomic datasets have recently been generated that have allowed identification of at least 4 subtypes of glioblastoma: classical, mesenchymal, proneural, and neural.14 Previous studies in glioblastoma geabbreviatioNs FBS = fetal bovine serum; HCC = hepatocellular carcinoma; HUVEC = human umbilical vein endothelial cell; lncRNA = long noncoding RNA; ncRNA = noncoding RNA; RT-qPCR = real-time quantitative reverse transcription polymerase chain reaction; SD = standard deviation. 3 Department of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing; and 4 Department of Oncology, The Second Affiliated Hospital of Suzhou University, Suzhou, China obJective Increased levels of H19 long noncoding RNA (lncRNA) have been observed in many cancers, suggesting that overexpression of H19 may be important in the development of carcinogenesis. However, the role of H19 in human glioblastoma is still unclear. The object of this study was to examine the level of H19 in glioblastoma samples and investigate the role of H19 in glioblastoma carcinogenesis. methods Glioblastoma and nontumor brain tissue specimens were obtained from tissue obtained during tumor resection in 30 patients with glioblastoma. The level of H19 lncRNA was detected by real-time quantitative reverse transcription polymerase chain reaction. The role of H19 in invasion, angiogenesis, and stemness of glioblastoma cells was then investigated using commercially produced cell lines (U87 and U373). The effects of H19 overexpression on glioblastoma cell invasion and angiogenesis were detected by in vitro Matrigel invasion and endothelial tube formation assay. The effects of H19 on glioblastoma cell stemness and tumorigenicity were investigated by neurosphere formation and an in vivo murine xenograft model. results The authors found that H19 is significantly overexpressed in glioblastoma tissues, and the level of expression was associated with patient survival. In the subsequent investigations, the authors found that overexpression of H19 promotes glioblastoma cell invasion and angiogenesis in vitro. Interestingly, H19 was also significantly overexpressed in CD133 + glioblastoma cells, and overexpression of H19 was associated with increased neurosphere formation of glioblastoma cells. Finally, stable overexpression of H19 was associated with increased tumor growth in the murine xenograft model. coNclusioNs The results of this study suggest that increased expression of H19 lncRNA promotes invasion, angiogenesis, stemness, and tumorigenicity of glioblastoma cells. Taken together, the...

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confidence: 99%

Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells

Jiang

Yan

et al. 2016

JNS

157

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“…For example, the expression of lncRNA BC200 is upregulated invarious human tumors, such as breast, lung, parotid gland, ovary, cervix, and tongue cancers, but it is undetectable incorresponding normal tissue (Chen et al, 1997;Iacoangeli et al, 2004). Similarly, H19, which is located within a cluster of imprinted genes on human chromosome 11 in p15.5, is expressed in many types of cancers, such as gastric, breast, liver, and esophageal, at significantly higher levels than in corresponding normal tissue (Hibi et al, 1996;Berteaux et al, 2008;He et al, 2014;. Other lncRNAs are expressed in normal tissues and act as tumor suppressor genes.…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNAs are Differentially Expressed in Hepatocellular Carcinoma Cell Lines with Differing Metastatic Potential

Fang

Sun²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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(Talmadge and Fidler, 2010). A salient feature of metastasis is the ability of cancer cells to colonize specific organ sites (Hanahan and Weinberg, 2011). For instance, HCC cells metastasize to the lung more frequently than the lymph nodes. It is well recognized that the probability of metastatic seeding and growth is determined by both intrinsic genetic properties of the cancer cells involved and characteristics of the stromal microenvironment that surrounds them (Lu and Kang, 2007;Nguyen et al., 2009). Functional genomic analysis of HCC cell lines with different organ-specific metastatic potential may provide new opportunities for identifying diagnostic biomarkers and developing therapies to combat HCC metastasis.Large-scale genomic studies have demonstrated that the mammalian genome encodes many thousands Ting-Ting Fang et al

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“…According to the molecular mechanism of, it can be divided into signal molecules, decoy molecules, scaffold molecules, and molecules [29].…”

Section: Biological Characteristics Of Lncrnamentioning

confidence: 99%

The Research Progress of Long Noncoding RNAs in Nasopharyngeal Carcinoma

Li¹,

Wu²,

Jiang³

et al. 2017

JCT

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Long noncoding RNA (lncRNA) is a leader of the degree of more than 200 nucleotides, almost do not have the function of protein coding endogenous RNA molecules. Recent studies show that, lncRNA is not encoded protein, but it has a wide range of biological functions, and lncRNA in human diseases, especially in oncology, more and more attention has been paid to its role. Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck in South China, which poses a serious threat to people's health and life. Studies found that lncRNA is widely involved in the invasion, metastasis and prognosis of nasopharyngeal carcinoma (NPC). In this article, we will review the research progress of lncRNA in nasopharyngeal carcinoma.

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Long noncoding RNAs: Novel insights into hepatocelluar carcinoma

Cited by 354 publications

References 122 publications

Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells

Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells

Long Non-coding RNAs are Differentially Expressed in Hepatocellular Carcinoma Cell Lines with Differing Metastatic Potential

The Research Progress of Long Noncoding RNAs in Nasopharyngeal Carcinoma

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