Long or Irregular Menstrual Cycles and Risk of Prevalent and Incident Nonalcoholic Fatty Liver Disease

Cho, In Young; Chang, Yoosoo; Kang, Jae-Heon; Kim, Yejin; Sung, Eunju; Shin, Hocheol; Byrne, Christopher D.; Ryu, Seungho

doi:10.1210/clinem/dgac068

Cited by 7 publications

(7 citation statements)

References 63 publications

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“…The impact of estrogen deficiency is reflected in the increased risk of NAFLD/NASH in women after menopause, in women following ovariectomy, and in women under antiestrogenic therapy for the treatment of hormone-sensitive breast cancer ( 27 , 78 ). Of note, long or irregular menstrual cycles are associated with an increased risk of NAFLD ( 79 ). Interestingly, studies have associated earlier menarche with NAFLD later in life ( 25 , 43 ).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Serum metabolomic profiling unveils distinct sex-related metabolic patterns in NAFLD

Fotakis,

Kalafati,

Amanatidou

et al. 2023

Front. Endocrinol.

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ObjectiveObesity poses an increased risk for the onset of Nonalcoholic fatty liver disease (NAFLD). The influence of other factors, such as sex in the incidence and severity of this liver disease has not yet been fully elucidated. Thus, we aimed to identify the NAFLD serum metabolic signatures associated with sex in normal, overweight and obese patients and to associate the metabolite fluctuations across the increasing liver steatosis stages.Methods and resultsUsing nuclear magnetic resonance (NMR) serum samples of 210 NAFLD cases and control individuals diagnosed with liver U/S, our untargeted metabolomics enquiry provided a sex distinct metabolic bouquet. Increased levels of alanine, histidine and tyrosine are associated with severity of NAFLD in both men and women. Moreover, higher serum concentrations of valine, aspartic acid and mannose were positively associated with the progression of NAFLD among the male subjects, while a negative association was observed with the levels of creatine, phosphorylcholine and acetic acid. On the other hand, glucose was positively associated with the progression of NAFLD among the female subjects, while levels of threonine were negatively related. Fluctuations in ketone bodies acetoacetate and acetone were also observed among the female subjects probing a significant reduction in the circulatory levels of the former in NAFLD cases. A complex glycine response to hepatic steatosis of the female subjects deserves further investigation.ConclusionResults of this study aspire to address the paucity of data on sex differences regarding NAFLD pathogenesis. Targeted circulatory metabolome measurements could be used as diagnostic markers for the distinct stages of NAFLD in each sex and eventually aid in the development of novel sex-related therapeutic options.

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Section: Strengths and Limitationsmentioning

confidence: 99%

Serum metabolomic profiling unveils distinct sex-related metabolic patterns in NAFLD

Fotakis,

Kalafati,

Amanatidou

et al. 2023

Front. Endocrinol.

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“…Measurements of fasting serum tests included lipid profiles and liver enzyme (aspartate aminotransferase, alanine transaminase, and gamma-glutamyltransferase [GGT]), high-sensitivity C-reactive protein, glucose, and insulin levels as previously detailed [ 20 , 25 ]. The homeostasis model assessment of insulin resistance was calculated.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Consumption Patterns and Risk of Early-Onset Vasomotor Symptoms in Premenopausal Women

et al. 2022

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The role of alcohol consumption in the risk of vasomotor symptoms (VMS), the most cardinal climacteric symptoms, is not well established. We examined their relationship with early-onset VMS among premenopausal women. Moderately-to-severely bothersome VMS, the primary outcome, was assessed using the Korean version of the Menopause-Specific Quality of Life questionnaire. The alcohol consumption categories included lifetime abstainer, former drinker, or current drinker, categorized as light, moderate, heavy, and very heavy. Compared with the lifetime-abstinence (reference), the multivariable-adjusted odds ratio (95% CIs) for prevalent VMS in alcohol consumption of <10, 10–19, 20–39, and ≥40 g/day were 1.42 (1.02–1.99), 1.99 (1.27–3.12), 2.06 (1.19–3.57), and 3.52 (1.72–7.20), respectively (p trend <0.01). Compared with the lifetime-abstinence, the multivariable-adjusted hazard ratios (95% CIs) for incident bothersome VMS among average alcohol consumption of <10, 10–19, 20–39, and ≥40 g/day were 1.10 (0.85–1.41), 1.03 (0.70–1.51), 1.72 (1.06–2.78), and 2.22 (1.16–4.23), respectively (p trend = 0.02). Increased alcohol consumption positively and consistently showed a relationship with increased risk of both prevalent and incident early-onset VMS. Refraining from alcohol consumption may help prevent bothersome VMS in premenopausal women.

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“…Есть данные, что раннее наступление менархе, длительные или нерегулярные менструальные циклы также связаны с повышенным риском как распространенной, так и повторной НАЖБП у молодых женщин в пременопаузе [46]. Синдром поликистозных яичников, которым страдают более 10% женщин репродуктивного возраста, также может быть фактором риска развития стеатоза печени и ассоциирован с более тяжелым течением НАСГ, включая прогрессирующий фиброз [47,48].…”

Section: пременопауза и нажбпunclassified

Features of the course of non-alcoholic fatty liver disease in women at different age periods: literature review

Bulatova,

Shevlyukova

2024

Medicinskij sovet

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The review examines the epidemiology and risk factors of non-alcoholic fatty liver disease (NAFLD) for women. According to various sources, the global prevalence of NAFLD ranges from 20 to 40% of the adult population in the world. In Russia, 37.3% of polyclinic patients have NAFLD. NAFLD can occur at any age and has differences in prevalence and severity depending on ethnicity and gender. Over the past 10 years, there has been a trend towards an increase in the prevalence of NAFLD among women, as well as a sharper increase in mortality compared to men. Regardless of gender, prognostically significant risk factors for NAFLD include age, obesity, type 2 diabetes mellitus, insulin resistance, dyslipidemia. The clinical course and prognosis of NAFLD in women depends on age, reproductive stage and use of synthetic hormones. Premenopausal women have less pronounced liver fibrosis and a better life prognosis compared to postmenopausal men and women. The article describes the features of the course of NAFLD in the reproductive period, pre- and postmenopausal period, characterizes the effect of liver steatosis on the course and outcome of pregnancy, the perinatal condition of the mother and fetus. Thus, there are gender differences in the prevalence, risk factors, fibrosis, and clinical outcomes of NAFLD. The prevalence and severity of NAFLD in reproductive age is higher in men, but after menopause, there is an increase in this pathology in women, especially those with metabolic disorders. Liver steatosis can affect the course of pregnancy, labor and postpartum periods.

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Long or Irregular Menstrual Cycles and Risk of Prevalent and Incident Nonalcoholic Fatty Liver Disease

Cited by 7 publications

References 63 publications

Serum metabolomic profiling unveils distinct sex-related metabolic patterns in NAFLD

Serum metabolomic profiling unveils distinct sex-related metabolic patterns in NAFLD

Alcohol Consumption Patterns and Risk of Early-Onset Vasomotor Symptoms in Premenopausal Women

Features of the course of non-alcoholic fatty liver disease in women at different age periods: literature review

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