Long range node‐strut analysis of trabecular bone microarchitecture

Schmah, Tanya; Marwan, Norbert; Thomsen, Jens Peter Frølund; Saparin, Peter

doi:10.1118/1.3622600

Cited by 5 publications

(2 citation statements)

References 72 publications

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“…Bone mineral density (BMD) is an fundamental predictor of fracture risk, bone strength, and overall bone condition [ 4 ]. Quantifying BMD enables the timely characterization and assessment of osteoporosis and the risk of bone fractures, respectively.…”

Section: Introductionmentioning

confidence: 99%

The correlation between serum total alkaline phosphatase and bone mineral density in young adults

Shu

Tan

et al. 2022

BMC Musculoskelet Disord

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Background Elevated total alkaline phosphatase (T-ALP) levels are usually indicative of enhanced osteoblastic activity and bone conversion status and are thus considered as a key factor needed for fresh bone mineralization and synthesis. To date, there is no consistent conclusion on the association between the serum T-ALP levels and bone mineral density (BMD). Therefore, the present study focused on exploring the association of serum T-ALP with lumbar BMD among young adults. Methods The present cross-sectional study included 6,331 subjects included in the National Health and Nutrition Examination Survey (NHANES) during 2011–2016. The participants aged 20–40 years included 3,349 males and 2,982 females. Serum T-ALP was our main variable, lumbar BMD was our outcome variable, and additional variables were the possible impact modifiers. The relations were analysed by the trend study, weighted multiple linear regression models, smooth curve fitting, and stratified analyses. Results In a completely corrected multiple regression model, a negative association between serum T-ALP and lumbar BMD was discovered (β = -0.0007, 95% CI: –0.0009– –0.0005, P < 0.000001). After converting the continuous variable serum T-ALP into the categorical one, the significant negative association was still observed (P < 0.001), and in the subgroup and smooth curve fitting analyses, this negative correlation remained significant, too. Conclusions Our study results indicated that serum T-ALP was negatively associated with lumbar BMD among young adults. Serum T-ALP measurement in the near future might become an effective biomarker to diagnose and treat osteoporosis on time.

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Section: Introductionmentioning

confidence: 99%

The correlation between serum total alkaline phosphatase and bone mineral density in young adults

Shu

Tan

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…[15][16][17] Strut analysis is a quantitative morphologic method that has been widely used to quantify the structural elements of various objects in the medical field, including trabecular pattern analysis. [18][19][20] In dentistry, many studies have used this method to screen for osteoporosis detection in periapical radiography. 5,14,21 Strut analysis has not yet been applied to multiple ROIs in panoramic radiography.…”

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confidence: 99%