Long-standing colonic inflammation is associated with a low prevalence of diverticuli in inflammatory bowel disease patients

Lahat, Adi; Avidan, Benjamin; Bar‐Meir, Simon; Chowers, Yehuda

doi:10.1002/ibd.20065

Cited by 18 publications

(18 citation statements)

References 16 publications

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“…cells in UDD patients compared to controls, without a mucosal lymphocyte infiltration in the peridiverticular area. In contrast, Pezzilli [18] did not find abnormal levels of fecal calprotectin, a marker of colonic inflammation, in patients with UDD, while, on the other hand, recent studies have suggested that chronic mucosal inflammation could prevent recurrent acute IBD flares or its development [19].…”

Section: Discussionmentioning

confidence: 87%

Absence of Mucosal Inflammation in Uncomplicated Diverticular Disease

et al. 2011

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Section: Discussionmentioning

confidence: 87%

Absence of Mucosal Inflammation in Uncomplicated Diverticular Disease

et al. 2011

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“…In contrast, Pezzilli et al [81] did not observe differences in fecal calprotectin concentrations between subjects with DD vs controls, though the study size was rather small (17 cases). More importantly, recent case-control studies of IBD suggest that chronic acute inflammation actually protects against DD [82,83] . The mechanisms by which this protection occurs are not yet understood, but may involve alterations to the luminal bolus, i.e.…”

Section: Inflammation and Ddmentioning

confidence: 99%

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane¹,

Arasaradnam²,

Mills³

et al. 2009

WJG

119

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Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.

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“…Eine Divertikulose ist bei chronisch-entzündlicher Darmerkrankung seltener zu beobachten [194,195]. Selbst wenn in der Biopsie Läsionen nachweisbar sind, die einer chronisch-entzündlichen Darmerkrankung ähnlich sind, ist der Nachweis solcher Läsionen nicht mit einer erhöhten Rate einer Colitis Crohn assoziiert [23,196].…”

Section: Kommentar Zu Statement 314unclassified

Failure to Use Ultrasound Is a Glaring Shortcoming

Läng¹

2018

Deutsches Ärzteblatt International

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Long-standing colonic inflammation is associated with a low prevalence of diverticuli in inflammatory bowel disease patients

Abstract: Long-standing colonic inflammation in IBD patients is associated with a lower prevalence of diverticuli.

Cited by 18 publications

References 16 publications

Absence of Mucosal Inflammation in Uncomplicated Diverticular Disease

Absence of Mucosal Inflammation in Uncomplicated Diverticular Disease

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Failure to Use Ultrasound Is a Glaring Shortcoming

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