Long-Term Adaptive Changes Induced by Antidepressants: From Conventional to Novel Therapies

Mnie-Filali, Ouissame; Abrial, Erika; Lambás‐Señas, Laura; Haddjeri, Nasser

doi:10.5772/54553

Cited by 1 publication

(1 citation statement)

References 224 publications

(191 reference statements)

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“…Regarding other neurotransmission systems, after chronic treatment, it has been suggested that sertraline has a minimal effect on dopamine and noradrenaline uptake, but it has been associated with a down-regulation of central β-adrenoceptors and an increase in the levels of cyclic adenosine monophosphate. Finally, it should be noted that in comparison with other SSRIs, sertraline does not present sedative effects, due to the absence of affinity for brain muscarinic and histamine H1-receptors [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Is Sertraline a Good Pharmacological Strategy to Control Anger? Results of a Systematic Review

Romero‐Martínez

Murciano-Martí

Moya-Albiol

2019

Behavioral Sciences

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Introduction: Extensive research has made it possible to conclude that dysfunctions in serotoninergic transmission are associated with a tendency toward violence and behavioral dysregulations in humans. In this regard, it has been suggested that selective serotonin reuptake inhibitors (SSRIs), such as sertraline, which regulate the serotonin system, might reduce proneness to violence. Aims: This review aims to explore changes in feelings of anger-state (e.g., irritability and hostility) and anger expression as primary outcomes after sertraline treatment. Methods: Based on PRISMA quality criteria for reviews, a literature search was carried out through PubMed, PsycINFO, Dialnet, Psicodoc, Web of Knowledge, and the Cochrane Library. Results: Initially, 605 publications were identified, removing 219 duplicate manuscripts and screening the titles and abstracts of the remaining 386 records. This process left 248 articles for full-text reading, finally including 15 entries. Thus, several empirical studies were included that employed different research designs. In this regard, we considered 3 case reports, 5 open clinical trials, and 7 randomized placebo-controlled trials. The majority of the studies were unanimous in concluding that a large percentage of patients with high irritability levels responded satisfactorily to sertraline treatment. In fact, their mood improved, and they experienced a reduction in irritability and anger expression after a few weeks of treatment (approximately two weeks). However, it was necessary to increase the sertraline dose after months of treatment to avoid exhaustion effects. Moreover, not all the patients responded to the treatment and it is particularly interesting that a small percentage of patients were refractory to treatment or even showed an increase in irritability after a few weeks of treatment. In those cases, it was necessary to discontinue the treatment or reduce the dose to the initial levels. Discussion: Although it is necessary to be cautious about the benefits of sertraline as a way to control anger and irritability, it is relevant to consider pharmacological strategies to reduce anger-state as coadjutant treatments to psychotherapy in order to promote lasting changes in violent populations.

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Section: Introductionmentioning

confidence: 99%