Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats

Garcez, Michelle Lima; Bellettini-Santos, Tatiani; Schiavo, Gustavo Luis; Calixto, Karen Vasconcelos; Mina, Francielle; Medeiros, Eduarda Behenck; Zabot, Gabriel Casagrande; Pereira, Nathalia de Souza; Nascimento, Natália Baltazar do; Tomaz, Débora B.; Manenti, Maria Cecília; Kucharska, Ewa; Rico, Eduardo Pacheco; Budni, Josiane

doi:10.1016/j.exger.2022.111873

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…A critical dimension of aging is the profound impact of lifestyle choices, particularly dietary habits [5,20,[22][23][24][25][26], on the trajectory of aging and the risk of age-related diseases [27][28][29][30][31][32][33][34][35][36][37][38][39]. In this context, high-fat diets (HFDs) have emerged as a pervasive element of modern dietary patterns, characterized by their excessive consumption of saturated fats and relatively low nutritional value [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Balasubramanian,

Kiss,

Gulej

et al. 2024

Nutrients

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High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay of HFD, obesity, and diabetes expedites the aging process and prematurely fosters age-related diseases. However, the underlying mechanisms driving these associations remain enigmatic. One of the most conspicuous hallmarks of aging is the accumulation of highly inflammatory senescent cells, with mounting evidence implicating increased cellular senescence in the pathogenesis of age-related diseases. Our hypothesis posits that HFD consumption amplifies senescence burden across multiple organs. To scrutinize this hypothesis, we subjected mice to a 6-month HFD regimen, assessing senescence biomarker expression in the liver, white adipose tissue, and the brain. Aging is intrinsically linked to impaired cellular stress resilience, driven by dysfunction in Nrf2-mediated cytoprotective pathways that safeguard cells against oxidative stress-induced senescence. To ascertain whether Nrf2-mediated pathways shield against senescence induction in response to HFD consumption, we explored senescence burden in a novel model of aging: Nrf2-deficient (Nrf2+/−) mice, emulating the aging phenotype. Our initial findings unveiled significant Nrf2 dysfunction in Nrf2+/− mice, mirroring aging-related alterations. HFD led to substantial obesity, hyperglycemia, and impaired insulin sensitivity in both Nrf2+/− and Nrf2+/+ mice. In control mice, HFD primarily heightened senescence burden in white adipose tissue, evidenced by increased Cdkn2a senescence biomarker expression. In Nrf2+/− mice, HFD elicited a significant surge in senescence burden across the liver, white adipose tissue, and the brain. We postulate that HFD-induced augmentation of senescence burden may be a pivotal contributor to accelerated organismal aging and the premature onset of age-related diseases.

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Section: Introductionmentioning

confidence: 99%

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Balasubramanian,

Kiss,

Gulej

et al. 2024

Nutrients

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“…Oxidative stress is characterized by an imbalance between the antioxidant system and pro-oxidant system resulting increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are considered oxidizing compounds (Sies et al 2017 ). Multiple investigations have proven that oxidative stress triggers neurodegenerative disorders (Garcez et al 2022 ; Santos et al 2013 ). Furthermore, DEHP-induced neurotoxicity was linked with oxidative stress in the brain via an increment in MDA and intracellular ROS and a reduction in SOD and GSH brain levels (Wu et al 2019 ; Safarpour et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Mitigating effect of ferulic acid on di-(2-ethylhexyl) phthalate-induced neurocognitive dysfunction in male rats with a comprehensive in silico survey

Khalifa,

Fayed,

Ahmed

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate threatening public health-induced neurotoxicity. This neurotoxicity is associated with behavioral and biochemical deficits in male rats. Our study investigated the neuroprotective effect of ferulic acid (FA) on male rats exposed to DEHP. Thirty-two male Wistar rats were assigned to four groups. Group I control rats received corn oil, group II intoxicated rats received 300 mg/kg of DEHP, group III received 300 mg/kg of DEHP + 50 mg/kg of FA, and group IV received 50 mg/kg of FA, all agents administrated daily per os for 30 days. Anxiety-like behavior, spatial working memory, and recognition memory were assessed. Also, brain oxidative stress biomarkers, including brain malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD), brain-derived neurotrophic factor (BDNF) as well as heme oxygenase-1 (HO-1) were measured. Moreover, brain histopathology examinations associated with immunohistochemistry determination of brain caspase-3 were also evaluated. Furthermore, docking simulation was adapted to understand the inhibitory role of FA on caspase-3 and NO synthase. Compared to DEHP-intoxicated rats, FA-treated rats displayed improved cognitive memory associated with a reduced anxious state. Also, the redox state was maintained with increased BNDF levels. These changes were confirmed by restoring the normal architecture of brain tissue and a decrement in the immunohistochemistry caspase-3. In conclusion, FA has potent antioxidant and antiapoptotic properties that confirm the neuroprotective activity of FA, with a possible prospect for its therapeutic capabilities and nutritional supplement value.

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Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning

Zhang,

Wang,

Peng

et al. 2024

Advanced Science

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Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, a previously unreported neuronal projection from the dorsal hippocampus (dHPC) to the zona incerta (ZI) involved in the regulation of ML behaviors is identified. Using recombinant adeno‐associated virus, the projections to the ZI are surprisingly identified as originating from the dorsal dentate gyrus (DG) and CA1 subregions of the dHPC. Furthermore, projection‐specific chemogenetic and optogenetic manipulation reveals that the projections from the dorsal CA1 to the ZI play key roles in the acquisition and consolidation of ML behaviors, whereas the projections from the dorsal DG to the ZI mediate the retrieval/retention of ML behaviors. The results reveal new projections from the dorsal DG and dorsal CA1 to the ZI involved in the regulation of ML and provide insight into the stages over which this regulation occurs.

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Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats

Cited by 3 publications

References 52 publications

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Mitigating effect of ferulic acid on di-(2-ethylhexyl) phthalate-induced neurocognitive dysfunction in male rats with a comprehensive in silico survey

Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning

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