2010
DOI: 10.1007/s13181-010-0081-y
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Long-term Alcohol Consumption Increases Pro-Matrix Metalloproteinase-9 Levels via Oxidative Stress

Abstract: Matrix metalloproteinases (MMPs) play an important role in alcoholic liver disease. In this study, we evaluated the relationship between pro MMP-9 (pMMP-9) and oxidative stress in plasma of rat exposed to chronic alcohol consumption. Twenty four rats were divided into four groups. Rats in the control group (n=6) were subjected to physiologic saline by intragastric (i.g.) route. Group Ethanol (n=6) was given 1 ml of 80% ethanol (v/v) in distilled water through i.g. route. Group Vitamin E (Vit E), (n = 6) was gi… Show more

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Cited by 21 publications
(15 citation statements)
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“…It has been shown that damage caused by H 2 O 2 -induced oxidative stress can be reduced by down-regulating the levels of MMP-9 [31]. Koken et al (2010) [32] have shown that long-term alcohol consumption increases MMP-9 levels via oxidative stress. They concluded that oxidative stress could be one of the mediators of the expression of MMP-9.…”
Section: Discussionmentioning
confidence: 99%
“…It has been shown that damage caused by H 2 O 2 -induced oxidative stress can be reduced by down-regulating the levels of MMP-9 [31]. Koken et al (2010) [32] have shown that long-term alcohol consumption increases MMP-9 levels via oxidative stress. They concluded that oxidative stress could be one of the mediators of the expression of MMP-9.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, inflammation is also one of the important underlying causes of preterm birth and the increased vitamin B 12 levels could be related to it. Moreover, we have also reported increased oxidative stress in women delivering preterm [40], which may be involved in the upregulation of proinflammatory cytokines as is observed in inflammatory conditions [41,42]. …”
Section: Discussionmentioning
confidence: 99%
“…The relation between oxidative stress and gelatinases has been mainly investigated with reference to cardiovascular risk [25,31,[65][66][67]. Molecules responsible for oxidative stress, such as peroxynitrite and hydrogen peroxide, promote the expression and activity of gelatinases [68][69][70][71][72]. ROS can influence transcription and post-transcriptional activation of MMPs [73]; moreover, treatment of monocyte-derived macrophages with oxidized LDL induces an overexpression of MMP-2 and MMP-9 [74].…”
Section: Obese Subjectsmentioning
confidence: 99%