Long-term and strong suppression against Microcystis growth and microcystin-release by luteolin continuous-release microsphere: Optimal construction, characterization, effects and proteomic mechanisms

Li, Biying; Li, Jieming; An, Guangqi; Zhao, Chunming; Wang, Chengyu

doi:10.1016/j.watres.2021.117448

Cited by 20 publications

(4 citation statements)

References 47 publications

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“…70,71 Regulation of psaB has been demonstrated to alter the downstream electron transport of carbon fixation. 72 Hence, compared to a single exposure, repeated CLA exposure more strongly inhibited electron transport from PSII to PSI, disrupting photosynthesis (carbon fixation), consistent with the observed downregulation of the carbon fixation pathway from metabolomics (Table S7). Observed thylakoid damage supported the finding of inhibited photosynthetic activity (Figure S5).…”

Section: ■ Discussionsupporting

confidence: 74%

“…Downregulation of psaB was also observed in M. aeruginosa under chloramphenicol and luteolin stress, inducing light obstruction and electron transport inhibition within the photosynthetic reaction center. , Regulation of psaB has been demonstrated to alter the downstream electron transport of carbon fixation . Hence, compared to a single exposure, repeated CLA exposure more strongly inhibited electron transport from PSII to PSI, disrupting photosynthesis (carbon fixation), consistent with the observed downregulation of the carbon fixation pathway from metabolomics (Table S7).…”

Section: Discussionsupporting

confidence: 69%

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Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Mao,

Ye,

Yang

et al. 2024

Environ. Sci. Technol.

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Antibiotics are being increasingly detected in aquatic environments, and their potential ecological risk is of great concern. However, most antibiotic toxicity studies involve single-exposure experiments. Herein, we studied the effects and mechanisms of repeated versus single clarithromycin (CLA) exposure on Microcystis aeruginosa. The 96 h effective concentration of CLA was 13.37 μg/L upon single exposure but it reduced to 6.90 μg/L upon repeated exposure. Single-exposure CLA inhibited algal photosynthesis by disrupting energy absorption, dissipation and trapping, reaction center activation, and electron transport, thereby inducing oxidative stress and ultrastructural damage. In addition, CLA upregulated glycolysis, pyruvate metabolism, and the tricarboxylic acid cycle. Repeated exposure caused stronger inhibition of algal growth via altering photosynthetic pigments, reaction center subunits biosynthesis, and electron transport, thereby inducing more substantial oxidative damage. Furthermore, repeated exposure reduced carbohydrate utilization by blocking the pentose phosphate pathway, consequently altering the characteristics of extracellular polymeric substances and eventually impairing the defense mechanisms of M. aeruginosa. Risk quotients calculated from repeated exposure were higher than 1, indicating significant ecological risks. This study elucidated the strong influence of repeated antibiotic exposure on algae, providing new insight into antibiotic risk assessment.

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Section: ■ Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 69%

Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Mao,

Ye,

Yang

et al. 2024

Environ. Sci. Technol.

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“…Next, Lut was efficiently loaded into the mesopores and hollow cavities of Cu-HN via physical adsorption. In the ultraviolet–visible (UV–vis) spectrum of Lut@Cu-HN (Figure e), two characteristic peaks of Lut at 274 and 401 nm were detected in the Lut@Cu-HN absorbance curve, revealing the successful loading of Lut with a high drug-loading capacity of 35.8% (w/w%, Figure f) . In addition, the average hydrolyzed diameter of Cu-HN increased to 102.1 nm, and the zeta potential turned to −35.3 mV after Lut loading (Figure g,h).…”

Section: Resultsmentioning

confidence: 99%

Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance

Zhu

Ding

et al. 2023

ACS Nano

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Implant-related infections (IRIs) are catastrophic complications after orthopedic surgery. Excess reactive oxygen species (ROS) accumulated in IRIs create a redox-imbalanced microenvironment around the implant, which severely limits the curing of IRIs by inducing biofilm formation and immune disorders. However, current therapeutic strategies commonly eliminate infection utilizing the explosive generation of ROS, which exacerbates the redox imbalance, aggravating immune disorders and promoting infection chronicity. Herein, a self-homeostasis immunoregulatory strategy based on a luteolin (Lut)-loaded copper (Cu 2+ )-doped hollow mesoporous organosilica nanoparticle system (Lut@Cu-HN) is designed to cure IRIs by remodeling the redox balance. In the acidic infection environment, Lut@Cu-HN is continuously degraded to release Lut and Cu 2+ . As both an antibacterial and immunomodulatory agent, Cu 2+ kills bacteria directly and promotes macrophage proinflammatory phenotype polarization to activate the antibacterial immune response. Simultaneously, Lut scavenges excessive ROS to prevent the Cu 2+ -exacerbated redox imbalance from impairing macrophage activity and function, thus reducing Cu 2+ immunotoxicity. The synergistic effect of Lut and Cu 2+ confers excellent antibacterial and immunomodulatory properties to

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“…Urban plant factories equipped with hydroponic cultivation, emerging as a globally revolutionized farming technology, show great potential for a stable and effective supply and consistent availability of food products to feed such expanding demands regardless of climatic and geographic conditions (Figure A). − However, harmful algae quickly proliferate and compete for nutrients with crops, resulting in massive reduction in crop production and collateral risks of plant diseases and insect pest invasion in hydroponic facilities as obstacles in these sustainable agriculture practices. Further, the inefficient overuse of pesticides and algaecides has been restricted due to the low efficiency (up to 99% of the agrochemicals are lost), , severe secondary pollution, and concerns regarding food safety, such as Cu-based algaecides. − Innovative technologies are critically desired for efficient algal bloom control for a minimized crop loss and validated food sustainability in a practical and environmentally friendly manner.…”

mentioning

confidence: 99%

Cell-Targeted Metal-Phenolic Nanoalgaecide in Hydroponic Cultivation to Enhance Food Sustainability

Wang,

Yang,

Huang

et al. 2023

ACS Nano

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Long-term and strong suppression against Microcystis growth and microcystin-release by luteolin continuous-release microsphere: Optimal construction, characterization, effects and proteomic mechanisms

Cited by 20 publications

References 47 publications

Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance

Cell-Targeted Metal-Phenolic Nanoalgaecide in Hydroponic Cultivation to Enhance Food Sustainability

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