Long-term blue light rearing does not affect in vivo retinal function in young rhesus monkeys

Lou, Linjiang; Frishman, Laura J.; Beach, Krista M.; Rajagopalan, Lakshmi; Hung, Li-Fang; She, Zhihui; Smith, Earl L.; Ostrin, Lisa A

doi:10.1007/s10633-023-09931-0

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…thermal quenching property of the Eu(TTA) 3 BIP complex makes it a potential temperature sensing material.…”

Section: Acnowledgmentsmentioning

confidence: 99%

“…Harmful blue light has extremely high energy and can penetrate the lens directly to the retina, causing atrophy or even death of retinal pigment epithelial cells [1,2] . The death of photosensitive cells can lead to decreased vision or even complete loss, and this damage is irreversible [3] . Therefore, it is necessary to develop effective blue light reducing materials.…”

Section: Introductionmentioning

confidence: 99%

“…[1,2] The death of photosensitive cells can lead to decreased vision or even complete loss, and this damage is irreversible. [3] Therefore, it is necessary to develop effective blue light reducing materials.…”

Section: Introductionmentioning

confidence: 99%

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Red Fluorescent Eu(TTA)₃BIP Complex and Its Application in Blue Light‐Reducing Film

Wang,

Shi,

Hao

et al. 2023

Zeitschrift anorg allge chemie

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In this work, a Eu(TTA)3BIP complex with a novel structure was synthesized and characterized. The Eu(TTA)3BIP complex has a wide excitation band and can be excited by light in the ultraviolet and blue regions. The characteristic red light of Eu(III) is emitted when the complex is excited. The use of the 2‐(Pyrimidin‐2‐yl)‐1H‐benzo[d]imidazole (BIP) ligand improved the UV resistance of the complex. Moreover, the blue light reducing film prepared by the Eu(TTA)3BIP complex can effectively weaken blue light irradiation. In addition, the Eu(TTA)3BIP complex exhibits fluorescence thermal quenching properties. This provides the possibility for temperature sensing.

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“…thermal quenching property of the Eu(TTA) 3 BIP complex makes it a potential temperature sensing material.…”

Section: Acnowledgmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Red Fluorescent Eu(TTA)₃BIP Complex and Its Application in Blue Light‐Reducing Film

Wang,

Shi,

Hao

et al. 2023

Zeitschrift anorg allge chemie

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“…Evidence suggests that BL exposure may be harmful, particularly in children, where increased screen time has been linked to poorer vision and a higher prevalence of myopia [24]. The causal relationship between short-wave light and myopia is further supported in studies on rhesus monkeys [25]; however, whether BL exposure from screen displays and LEDs can result in retinal damage remains controversial. Almost all studies on BL to date have a common weak point, which is that intense BL exposure is used over a short period of time [26].…”

Section: Introductionmentioning

confidence: 99%

Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis

Fietz,

Corsi,

Hurst

et al. 2023

Antioxidants

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In the digital age, the widespread presence of electronic devices has exposed humans to an exceptional amount of blue light (BL) emitted from screens, LEDs, and other sources. Studies have shown that prolonged exposure to BL could have harmful effects on the visual system and circadian rhythm regulation. BL is known to induce oxidative stress, leading to DNA damage. Emerging research indicates that BL may also induce cell death pathways that involve the tumor-suppressor protein p53. Activated p53 acts as a transcription factor to regulate the expression of genes involved in cell cycle arrest, DNA repair, and apoptosis. This study aimed to explore the implication of p53 in BL-caused retinal damage, shedding light on the potential mechanisms of oxidative-stress-induced retinal diseases. BL-exposed porcine retinal cultures demonstrated increased p53- and caspase-mediated apoptosis, depending on exposure duration. Direct inhibition of p53 via pifithrin α resulted in the prevention of retinal cell death. These findings raise concerns about the long-term consequences of the current daily BL exposure and its potential involvement in various pathological conditions, including oxidative-stress-based retinal diseases like age-related macular degeneration. In addition, this study paves the way for the development of novel therapeutic approaches for oxidative-stress-based retinal diseases.

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Violet Light Effects on the Circadian Rest–Activity Rhythm and the Visual System

Domínguez-Valdés,

Bonnin-Arias,

Alvarez-Peregrina

et al. 2024

Clocks & Sleep

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Background: Rooms illuminated by “black light” (<400 nm wavelength) has become popular, but there is not enough scientific evidence to support its implementation. This study aims to assess the effects of violet light (392 nm) on the circadian rest–activity rhythm and the visual system through animal experimentation. Materials and results: Five groups of four mice were exposed to different white light, violet light, and dark periods, and their circadian rhythm was analyzed by measuring the circadian period using rest–activity cycles. Electroretinographic recordings and structural analysis of the retina were also performed on experimental animals. Results: Our study demonstrates that mice present normal circadian activity during exposure to violet light, taking rest not only under white light but under violet lighting periods. However, mice suffered a decrease in electrical retinal response after exposure to violet light as measured by electroretinography. Nevertheless, no structural changes were observed in the retinas of the animals under different lighting conditions. Conclusions: Violet light elicits circadian rest–activity rhythm in mice but alters their visual function, although no structural changes are observed after short periods of violet light exposure.

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Long-term blue light rearing does not affect in vivo retinal function in young rhesus monkeys

Cited by 3 publications

References 46 publications

Red Fluorescent Eu(TTA)₃BIP Complex and Its Application in Blue Light‐Reducing Film

Red Fluorescent Eu(TTA)₃BIP Complex and Its Application in Blue Light‐Reducing Film

Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis

Violet Light Effects on the Circadian Rest–Activity Rhythm and the Visual System

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Long-term blue light rearing does not affect in vivo retinal function in young rhesus monkeys

Cited by 3 publications

References 46 publications

Red Fluorescent Eu(TTA)3BIP Complex and Its Application in Blue Light‐Reducing Film

Red Fluorescent Eu(TTA)3BIP Complex and Its Application in Blue Light‐Reducing Film

Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis

Violet Light Effects on the Circadian Rest–Activity Rhythm and the Visual System

Contact Info

Product

Resources

About

Red Fluorescent Eu(TTA)₃BIP Complex and Its Application in Blue Light‐Reducing Film

Red Fluorescent Eu(TTA)₃BIP Complex and Its Application in Blue Light‐Reducing Film