Long‐term combination therapy with metformin and oxymetholone in a Fanconi anemia mouse model
Craig Dorrell,
Alexander M. Peters,
Qingshuo Zhang
et al.
Abstract:Fanconi anemia (FA) is a disease caused by defective deoxyribonucleic acid (DNA) repair that manifests as bone marrow failure, cancer predisposition, and developmental defects. We previously reported that monotherapy with either metformin (MET) or oxymetholone (OXM) improved peripheral blood (PB) counts and the number and functionality of bone marrow hematopoietic stem progenitor cells (HSPCs) number in Fancd2−/− mice. To evaluate whether the combination treatment of these drugs has a synergistic effect to pre… Show more
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