Elevated acid deposition has been a concern in the central Appalachian region for decades. A long-term acidification experiment on the Fernow Experimental Forest in central West Virginia was initiated in 1996 and continues to this day. Ammonium sulfate was used to simulate elevated acid deposition. A concurrent lime treatment with an ammonium sulfate treatment was also implemented to assess the ameliorative effects of base cations to offset acidification. We show that the forest vegetation simulator growth model can be locally calibrated and used to project stand growth and development over 40 years to assess the impacts of acid deposition and liming. Modeled projections showed that pin cherry (initially) and sweet birch responded positively to nitrogen and sulfur additions, while black cherry, red maple, and cucumbertree responded positively to nitrogen, sulfur, and lime. Yellow-poplar negatively responded to both treatments. Despite these differences, our projections show a maximum of 5% difference in total stand volume among treatments after 40 years.