Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice

Min, Gyeong; Kwon, Eun Young; Kim, Hye Jin; Jeon, Soyeon; Ha, Tae Youl; Park, Tae Sun; Choi, Myung Sook

doi:10.1016/j.bbrc.2008.06.113

Cited by 116 publications

(86 citation statements)

References 30 publications

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“…RV also has promising neuroprotective and cardioprotective effects, as well as slowing aging and delaying the onset of chronic diseases 23,[28][29][30] . Resveratrol supplements significantly reduced the presence of atherosclerotic lesions and lipid levels in apo E-deficient mice 31,32) and type 1 diabetic LDL receptor-deficient mice 33) . The critical role of SirT1 in vascular endothelial homeostasis and its beneficial effects on metabolic pathways, such as regulating cholesterol homeostasis, suggests its therapeutic potential for the treatment of cardiovascular diseases 34,35) .…”

Section: Discussionmentioning

confidence: 94%

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

Kao

Chen

Chang

et al. 2010

JAT

220

143

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Section: Discussionmentioning

confidence: 94%

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

Kao

Chen

Chang

et al. 2010

JAT

220

143

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“…The present study showed that these particular genes might regulate energy metabolism in the HepG2 cells. Other natural products have been used to examine lipid lowering effects, such as hesperidin, naringin (Jung et al, 2006), resveratrol (Do et al, 2008), and curcumin (Jang et al, 2008), which could also decrease hepatic HMG-CoAR. In contrast, red wine polyphenols (Pal et al, 2003) and anthocyanins in black sticky rice (Sangkitikomol et al, 2010) have been shown to increase hepatic LDLR.…”

Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

Sangkitikomol¹,

Rocejanasaroj²,

Tencomnao³

2014

Genet. Mol. Res.

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ABSTRACT. In Thai traditional medicine, Moringa oleifera is used for the treatment of diabetes and hyperlipidemia. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases, such as hyperlipidemia, diabetes mellitus, and cardiovascular disease. We evaluated the antioxidant effect of M. oleifera extract (MOE) for reduction of advanced glycation end-product (AGE) formation, cell viability, oxidative stress, and lipid metabolism gene expression in HepG2 cells. We found that the lyophilized form of MOE in 80% ethanol possessed mean (± SD) total antioxidant, polyphenolic, and flavonoid contents of 9307 ± 364 TE mM/kg dry mass, 218 ± 1 GE mM/kg dry mass, and 286 ±12 QE mM/kg dry mass, determined using an oxygen radical absorbance capacity assay, a Folin Ciocalteu phenol assay, and a total flavonoids assay, respectively. Concentrations of 2.5-10.0 mg/ mL MOE could inhibit AGE-formation by 10-45%, and 100-1000 mg/L MOE reduced intracellular oxidative stress (P < 0.05) in a dose-dependent manner in the DCFH-DA assay. However, MOE induced cytotoxicity at high doses (2000-3000 mg/L), as shown by the MTT assay. MOE significantly downregulated the mRNA expression of the HMG-CoAR, PPARα1, and PPARγ genes (P < 0.05). We concluded that M. oleifera could have benefits for human health by reducing oxidative stress and AGE formation. Moreover, M. oleifera may reduce cholesterol and lipid synthesis by suppression of HMG-CoAR, PPARα1, and PPARγ gene expression, thereby maintaining lipid homeostasis.

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“…35 Some epidemiological studies have indicated that higher the apoB/apoA-I ratio, the higher the CV risk is because high TG and low HDL-C are also part of the atherogenic lipid profile. 35,36 A report by Do et al 37 showed the spontaneous HDL-C-raising and TG-lowering effects of resveratrol in normal diet fed apoEdeficient mice. In general, there is an inverse relationship between plasma TG and HDL-C, 38 and the results of this study show a substantial decrease in plasma TG coupled with an increase in HDL-C as well as an increase in the apoB/apoA-I ratio.…”

Section: Figmentioning

confidence: 99%

Antiobesity and Vasoprotective Effects of Resveratrol in ApoE-Deficient Mice

Jeon

Lee

Choi

2014

Journal of Medicinal Food

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This study was performed to investigate the hypolipidemic, antiobese, and antiatherogenic effects of resveratrol in apoE-deficient mice fed an atherogenic diet (20% fat and 1% cholesterol). These animals were fed an atherogenic diet containing 0.02% lovastatin (w/w) or 0.02% resveratrol (w/w) for 12 weeks. Resveratrol and lovastatin supplementation significantly reduced either the body weight or epididymal fat weight without altering the food intake and food efficiency ratio. Resveratrol significantly decreased the plasma total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) concentrations, apoB/apoA-I ratio, hepatic cholesterol, and triglyceride (TG) contents, whereas significantly it increased the plasma HDL-C concentration compared with the control and lovastatin groups. Plasma and hepatic TG and plasma apoB levels were significantly lower in both the lovastatin and resveratrol groups than in the control group without altering the plasma apoA-I concentration. Both resveratrol and lovastatin significantly decreased hepatic fatty acid and TG synthesis, whereas they increased fatty acid oxidation (b-oxidation) except for the carnitine palmitoyltransferase activity compared with the control group. However, there was no difference in hepatic 3-hydroxyl-3-methylglutaryl-CoA reductase activity among the groups, although hepatic acyl-CoA: cholesterol acyltransferase activity was significantly lower in the lovastatin groups than in the control group. In epididymal adipose tissue, resveratrol supplementation led to an increase in b-oxidation and decrease in TG synthesis, compared with the control group. Tissue morphology revealed that there were dramatic decreases in hepatic lipid droplets and aortic fatty streaks by resveratrol and lovastatin supplementation. This study demonstrates that resveratrol exerts not only antiobesity and hypolipidemic effects, but also protective effects for the liver and aorta through the modulation of lipid metabolism in both the liver and white adipose tissues.

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Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice

Cited by 116 publications

References 30 publications

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

Antiobesity and Vasoprotective Effects of Resveratrol in ApoE-Deficient Mice

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