Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort

Taj, Tahir; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Poulsen, Aslak Harbo; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Jørgensen, Jeanette T.; Katsouyanni, Klea; Ketzel, Matthias; Lager, Anton; Leander, Karin; Liu, Shuo; Ljungman, Petter; Severi, Gianluca; Besson, Caroline; Magnusson, Patrik K.E.; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Rizzuto, Debora; Samoli, Evangelia; Sørensen, Mette; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole

doi:10.1016/j.envpol.2023.123097

Cited by 4 publications

(5 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most previous research on outdoor air pollutants and haematologic cancers has focused on broad groups that do not account for aetiologic heterogeneity. Common groups examined include “leukaemia” [ 2 – 6 , 8 , 26 , 27 ], “leukaemia and lymphoma” [ 28 ], “haematologic cancer” [ 29 ], or “non-Hodgkin lymphomas (NHL)” [ 2 , 3 , 5 ]. Of the prospective cohorts, one large US study of PM 2.5 and fatal cancers found increased risks of leukaemia and NHL [ 2 ], as did a pooled European cohort of NO 2 with leukaemia and PM 2.5 with lymphoma [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Common groups examined include “leukaemia” [ 2 – 6 , 8 , 26 , 27 ], “leukaemia and lymphoma” [ 28 ], “haematologic cancer” [ 29 ], or “non-Hodgkin lymphomas (NHL)” [ 2 , 3 , 5 ]. Of the prospective cohorts, one large US study of PM 2.5 and fatal cancers found increased risks of leukaemia and NHL [ 2 ], as did a pooled European cohort of NO 2 with leukaemia and PM 2.5 with lymphoma [ 5 ]. However, another large US study found no associations with PM 2.5 , NO 2 , or O 3 for the same sites [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…A population-based case-control study in Denmark [ 7 ] found no overall association with Hodgkin lymphoma, but there was an elevated risk of the classical Hodgkin lymphoma sub-type for PM 2.5 per 5 μg/m 3 (HR = 1.21, 95%CI 0.96–1.54). Low-level exposure to PM 2.5 in Europe [ 5 ] showed an elevated although non-significant association with Hodgkin lymphoma (HR per 5 μg/m 3 = 1.31, 95%CI 0.79–2.16). A large US cohort study of fatal cancer [ 2 ] identified a statistically significant association of 10 μg/m 3 of PM 2.5 with a higher risk of Hodgkin lymphoma (HR = 4.18, 95%CI 1.20–14.60).…”

Section: Discussionmentioning

confidence: 99%

“…However, findings from other large-scale prospective cohort studies of mortality in the US [ 3 ] and Denmark [ 4 ] have not reported evidence for associations with PM 2.5 or other ambient air pollutants. However, a recent pooled study of low-level air pollution in Europe showed associations of NO 2 with leukaemia and PM 2.5 with lymphoma [ 5 ]. Findings from case-control studies [ 6 – 8 ] have been equally inconsistent though some positive associations were reported among sub-populations.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Outdoor air pollution and risk of incident adult haematologic cancer subtypes in a large US prospective cohort

Diver,

Teras,

Deubler

et al. 2024

Br J Cancer

View full text Add to dashboard Cite

Background Outdoor air pollution and particulate matter (PM) are classified as Group 1 human carcinogens for lung cancer. Pollutant associations with haematologic cancers are suggestive, but these cancers are aetiologically heterogeneous and sub-type examinations are lacking. Methods The American Cancer Society Cancer Prevention Study-II Nutrition Cohort was used to examine associations of outdoor air pollutants with adult haematologic cancers. Census block group level annual predictions of particulate matter (PM2.5, PM10, PM10-2.5), nitrogen dioxide (NO2), ozone (O3), sulfur dioxide (SO2), and carbon monoxide (CO) were assigned with residential addresses. Hazard ratios (HR) and 95% confidence intervals (CI) between time-varying pollutants and haematologic subtypes were estimated. Results Among 108,002 participants, 2659 incident haematologic cancers were identified from 1992–2017. Higher PM10-2.5 concentrations were associated with mantle cell lymphoma (HR per 4.1 μg/m3 = 1.43, 95% CI 1.08–1.90). NO2 was associated with Hodgkin lymphoma (HR per 7.2 ppb = 1.39; 95% CI 1.01–1.92) and marginal zone lymphoma (HR per 7.2 ppb = 1.30; 95% CI 1.01–1.67). CO was associated with marginal zone (HR per 0.21 ppm = 1.30; 95% CI 1.04–1.62) and T-cell (HR per 0.21 ppm = 1.27; 95% CI 1.00–1.61) lymphomas. Conclusions The role of air pollutants on haematologic cancers may have been underestimated previously because of sub-type heterogeneity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outdoor air pollution and risk of incident adult haematologic cancer subtypes in a large US prospective cohort

Diver,

Teras,

Deubler

et al. 2024

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Hematological malignancies are broadly categorized into lymphoma, which originates from the lymphatic system; multiple myeloma (MM), which affects plasma cells in the bone marrow; and leukemia, which impacts cells in the bone marrow or blood [ 2 ]. Currently, many observational studies have investigated the etiology of hematological malignancies, including factors such as air pollution, chlamydia contamination, and dietary habits, among others [ 3 , 4 ]. However, due to the multitude of confounding factors in retrospective studies, many causative factors still cannot be conclusively determined.…”

Section: Introductionmentioning

confidence: 99%

Genetically determined telomere length as a risk factor for hematological malignancies: evidence from Mendelian randomization analysis

Fang,

Zhang,

Ren

et al. 2024

Aging

View full text Add to dashboard Cite

Background: Over the past years, the exact correlation between telomere length and hematological malignancies was still not fully understood. Methods: We performed a two-sample Mendelian randomization study to investigate the causal relationship between telomere length and hematological malignancies. We selected genetic instruments associated with telomere length. The genetic associations for lymphoid and hematopoietic malignant neoplasms were obtained from the most recent publicly accessible FinnGen study R9 data. Inverse variant weighted (IVW) analysis was adopted as the primary method, and we also performed the weighted-median method and the MR-Egger, and MRPRESSO methods as sensitive analysis. Results: Significant associations have been observed between telomere length and primary lymphoid (IVW: OR = 1.52, P = 2.11 × 10 −6 ), Hodgkin lymphoma (IVW: OR = 1.64, P = 0.014), non-Hodgkin lymphoma (IVW: OR = 1.70, P = 0.002), B-cell lymphoma (IVW: OR = 1.57, P = 0.015), non-follicular lymphoma (IVW: OR = 1.58, P = 1.7 × 10 −3 ), mantle cell lymphoma (IVW: OR = 3.13, P = 0.003), lymphoid leukemia (IVW: OR = 2.56, P = 5.92E-09), acute lymphocytic leukemia (IVW: OR = 2.65, P = 0.021) and chronic lymphocytic leukemia (IVW: OR = 2.80, P = 8.21 × 10 −6 ), along with multiple myeloma (IVW: OR = 1.85, P = 0.016). Conclusion: This MR study found a significant association between telomere length and a wide range of hematopoietic malignancies. But no substantial impact of lymphoma and hematopoietic malignancies on telomere length has been detected.

show abstract

MTLPM: a long-term fine-grained PM2.5 prediction method based on spatio-temporal graph neural network

Hu,

Liao,

Yuan

et al. 2024

Environ Monit Assess

View full text Add to dashboard Cite

Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort

Cited by 4 publications

References 70 publications

Outdoor air pollution and risk of incident adult haematologic cancer subtypes in a large US prospective cohort

Outdoor air pollution and risk of incident adult haematologic cancer subtypes in a large US prospective cohort

Genetically determined telomere length as a risk factor for hematological malignancies: evidence from Mendelian randomization analysis

MTLPM: a long-term fine-grained PM2.5 prediction method based on spatio-temporal graph neural network

Contact Info

Product

Resources

About