Long-term exposure to electromagnetic radiation from mobile phones can cause considerable changes in the balance of Bax/Bcl2 mRNA expression in the hippocampus of mice

Tohidi, Fatemeh-Zakieh; Sadrnabavi, Arianeh; Haghir, Hossein; Fardid, Reza; Rafatpanah, Houshang; Azimian, Hosein; Bahreyni-Toossi, Mohammad-Hossein

doi:10.1080/15368378.2020.1830793

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Radiation from mobile phones causes the death of various cell types, including PCNs. [ 58–61 ] In the present study, exposure to mobile phone radiation caused significant decrease in the cell viability indicating the neuronal cell death, which is in par with the previous report. [ 35 ] Further, it was signified that cell death occurred due to the EMR of mobile phones by cell cycle analysis using the PI probe.…”

Section: Discussionsupporting

confidence: 89%

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Saka

Chitra

Narayanasamy³

2023

J Biochem & Molecular Tox

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Electromagnetic radiation (EMR) from wireless devices, particularly mobile phones, is a potentially growing public health concern. In this study, the neuronal effects of EMR on primary cortical neurons (PCNs) from neonatal rat cerebral cortex and the protective role of hispolon (HIS) and its derivatives were investigated as a measure of cranial exposure during mobile phone use. PCNs were isolated and cultured from day-old neonatal rats, then exposed for 2 h to EMR emitted by a mobile phone operating at a frequency of 2100 MHz with 1.6 W/Kg specific absorption rate (SAR) in call-answered mode treated with HIS and its derivatives. The induction of apoptosis through modulation of pro and anti-apoptotic genes via mitochondrial pathway and the protection by the test compounds was assessed. Pyrazole derivatives decreased apoptosis by modulating the levels of pro and anti-apoptotic genes by reducing the levels of reactive oxygen species (ROS) via mitochondrial damage, which was observed in the EMR exposed PCNs. The pyrazole compounds were found to have antioxidative and anti-apoptotic properties. Thus, the neuroprotective mechanisms of the pyrazole derivatives can be investigated further, which may make them appropriate as lead compounds in developing neuroprotective formulations.

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Section: Discussionsupporting

confidence: 89%

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Saka

Chitra

Narayanasamy³

2023

J Biochem & Molecular Tox

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“…Tohidi et al also investigated affected hippocampus tissues that were exposed to 900MHz and 1800MHz electromagnetic radiation 0.5, 1, 2, and 4 hours twice a day for 30 days. They determined that cell phone exposure can cause considerable changes in the balance of Bax/ Bcl2 mRNA expression in the hippocampus of mice [22]. Also, there are many in-vivo and in-vitro studies on brain tissue have demonstrated molecular alterations that are stimulated with cell phone radiation [5][6][7]23].…”

Section: Discussionmentioning

confidence: 99%

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field

Arslan,

Aras,

Yaman

et al. 2024

Med-Science

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Heat Shock Proteins (HSPs) may induce various cellular processes, including replication, apoptosis, cell-cycle progression. Mitogen-activated protein kinase (MAPK) cascades are the primary mechanism that mediates the cellular stress response to extracellular stimuli and regulates transcriptional activity. It has been shown that mobile phone exposure can stimulate the Hsp27/p38MAPK stress pathway. In this study, twenty-seven mature female Wistar albino rats were exposed to 1.8 GHz radiofrequency electromagnetic field (RF-EMF) 2h/day for 8 weeks (SAR: 0.06 W/kg). Hsp27 and p38MAPK gene expressions were investigated in rat brains. Rats were divided into groups sham-exposed, cage control, and 1.8 GHz RF-EMF exposed. Hsp27 and p38MAPK gene expression levels were investigated from the brain. p38MAPK expression was found to be upregulated in RF-EMF exposed group (p=0.018) Hsp27 expressions were not altered (p=0.897). In conclusion, long-term exposure to 1.8 GHz cell phone radiation can activate the Hsp27/p38MAPK stress pathway. It may cause several cellular disorders and can affect brain function.

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“…A recent study reported that Radio frequencies emitted by mobile phones disturb the mRNA expression of Bax/Bcl2 in the hippocampus of mice [80]. In contrast, it significantly increased the expression of c-fos mRNA in pregnant mice [81].…”

Section: Fig 4 Effects Of Rf-emf On Neurodegeneration Cancer and Ment...mentioning

confidence: 99%

Effects of Exposure to Electromagnetic Fields (EMFs) on Biological Systems

Pawar,

Martin

2024

AJOB

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Electromagnetic Field (EMF) is a natural phenomenon; however, anthropogenic activities have significantly shifted its equilibrium, leading to potential deleterious effects on biological systems. As technology becomes more integrated into daily life, the increased use of electronic devices has contributed to a rise in man-made EMF exposure. This exposure can affect biological systems on physiological and molecular levels, raising concerns about its potential effects on animal development, reproductive systems, and overall ecosystem health. The review explores the physiological effects of exposure to static, extremely low-frequency (ELF), and radiofrequency (RF) fields, analyzing how EMF impacts oxidative stress, reproductive physiology, cardiovascular function, brain and nervous system activity, and DNA/RNA integrity. It also acknowledges the emerging concern of EMF in aquatic environments, where underwater power supplies and extensive underwater cable networks are sources of EMF exposure that may affect marine and freshwater species. The potential effects on marine life include disruptions to migratory patterns, altered reproductive cycles, and changes in aquatic biodiversity. The review acknowledges that research on EMF has improved over time, but significant gaps and information remain. It emphasizes the need for immediate attention to address the challenges and opportunities in this field.

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Long-term exposure to electromagnetic radiation from mobile phones can cause considerable changes in the balance of Bax/Bcl2 mRNA expression in the hippocampus of mice

Cited by 5 publications

References 20 publications

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field

Effects of Exposure to Electromagnetic Fields (EMFs) on Biological Systems

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