Long-term Follow-up of a Randomized Clinical Trial Comparing Endovascular Revascularization Plus Supervised Exercise With Supervised Exercise Only for Intermittent Claudication

Abstract

H.J.M. Verhagen is a consultant to Medtronic and WL Gore & Associates and received an unrestricted educational grant from Abbott. MGM Hunink receives Royalties from Cambridge University Press for her textbook on Medical Decision Making, reimbursement of expenses from the European Society of Radiology (ESR) for work on the ESR guidelines for imaging referrals, reimbursement of expenses from the European Institute for Biomedical Imaging Research (EIBIR) for membership of the Scientific Advisory Board, and research funding from the American Diabetes Association, the Netherlands Organization for Health Research and Development, the German Innovation Fund, Netherlands Educational Grant ("Studie Voorschot Middelen"), and the Gordon and Betty Moore Foundation. Authors contribution: Sanne Klaphake, MD, contribution to the concept and design of the ERASE study acquisition of data analysis an interpretation of data participate in drafting the article and revising it critically give final approval of the version to be published Farzin Fakhry, MD, contribution to the concept and design of the ERASE study acquisition of data analysis an interpretation of data participate in drafting the article and revising it critically give final approval of the version to be published EllenV. Rouwet, MD, PhD, contribution to the concept and design of the ERASE study acquisition of data analysis an interpretation of data participate in drafting the article and revising it critically give final approval of the version to be published Lijckle van der Laan, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Jan J. Wever, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Joep A. W. Teijink, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Wolter H. Hoffmann, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Andre S. van Petersen, MD, acquisition of data participate in revising it critically give final approval of the version to be published Jerome P. van Brussel, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Guido N. M. Stultiens, MD, acquisition of data participate in revising it critically give final approval of the version to be published Alex Derom, MD, acquisition of data participate in revising it critically give final approval of the version to be published P. Ted den Hoed, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Gwan H. Ho, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Lukas C. van Dijk, MD, PhD, acquisition of data participate in revising it critically give final approval of the version to be published Nicole Verhofstad, PhD, acquisition of data parti...

Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD

“…The long-term results from several moderate-sized RCTs suggest that early advantages of endovascular revascularization over exercise may be lost over time and that patients undergoing intervention early are subject to a significantly larger number of procedures during follow-up. 58–61 Hence, the treatment approach to IC should be both staged and selective, in accordance with current guidelines.…”

Long-Term Outcomes of Exercise Therapy Versus Revascularization in Patients With Intermittent Claudication

“…Finally, our search strategy yielded 22 reports of 9 relevant studies. [22][23][24][25][26][27][28][29][30] Data of longest follow-up from each study were used. Overall risk of bias was low for all studies (Supplemental Figure 1, Supplemental Digital Content 1, http://links.lww.com/SLA/E413).…”

“…Six RCTs did not describe the outcomes of our interest. Finally, our search strategy yielded 22 reports of 9 relevant studies 22–30 . Data of longest follow-up from each study were used.…”

Editor's Choice – Randomised Clinical Trial of Supervised Exercise Therapy vs. Endovascular Revascularisation for Intermittent Claudication Caused by Iliac Artery Obstruction: The SUPER study

“…In ERASE, differences in walking distance and Qol at one year follow up favoured combination therapy but were not sustained after five years, despite a larger number of interventions in this group. 17 The longevity of interventions for IC is also questioned by the long term results of the IRONIC RCT in which patients with IC were allocated to any intervention plus structured exercise therapy (ET) and best medical therapy (BMT) vs. ET and BMT alone.…”