Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation

Sun, Yang; Yin, Sheng; Cui, Jian; Wang, Zhongxia; Han, Yueying; Ma, Ding; Wang, Shuo; Wu, Junhua; Cao, Yi; Jiang, Chunping; Gu, Xiaosong

doi:10.1007/s12274-023-5940-3

Cited by 6 publications

(2 citation statements)

References 99 publications

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“…Moreover, the interconnected macro-porous structural materials with good biocompatibility and degradability can be easily manufactured by 3D printing, which are very similar to the extracellular matrix (ECM). 17 As a result, it can more easily transfer nutrients, oxygen, and metabolites, and encourage angiogenesis and cell proliferation, which is crucial to wound healing. 18−21 The ideal hemostatic material should have good hemostatic capacity, excellent biocompatibility, and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

“…Together with the wide filament spacing, the porous structure of the aerogel gauze allows blood to pass through and be rapidly absorbed. Moreover, the interconnected macro-porous structural materials with good biocompatibility and degradability can be easily manufactured by 3D printing, which are very similar to the extracellular matrix (ECM) . As a result, it can more easily transfer nutrients, oxygen, and metabolites, and encourage angiogenesis and cell proliferation, which is crucial to wound healing. − …”

Section: Introductionmentioning

confidence: 99%

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3D Printed Porous Okara-Based Sponge with Hemostatic and Antimicrobial Effects for Wound Healing

Fang,

Wu,

et al. 2024

ACS Sustainable Chem. Eng.

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Bleeding and wound infections are two major threats to patients' lives. Creating a hemostatic sponge with efficient antibacterial ability, good hemostatic ability, and the ability to accelerate wound healing has become an important requirement. In this work, okara, an agricultural waste, was used for green reduction of silver nanoparticles (AgNPs). Okara-AgNP composite hemostatic sponges were then created using 3D printing and freeze-drying techniques. These sponges had a highly interconnected three-dimensional porous structure and can absorb liquids. In comparison to commercial poly vinyl formal (PVF) sponges, this sponge exhibited superior hemostasis (BCI value of 24.5%, significantly higher than PVF 53.1%), antibacterial ability (achieving 95.1% and 94.4%, against Escherichia coli and Staphylococcus aureus, respectively), and biosafety. Moreover, it showed an extremely high 87.8% wound healing rate on day 9. Additionally, because of its outstanding printability, print shapes can be designed in any way to meet the needs of different occasions. Okara-AgNP composite hemostatic sponges have much promise for usage as materials for wound hemostasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D Printed Porous Okara-Based Sponge with Hemostatic and Antimicrobial Effects for Wound Healing

Fang,

Wu,

et al. 2024

ACS Sustainable Chem. Eng.

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Mechanochemistry: Fundamental Principles and Applications

Dong,

Li,

Chen

et al. 2024

Advanced Science

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Mechanochemistry is an emerging research field at the interface of physics, mechanics, materials science, and chemistry. Complementary to traditional activation methods in chemistry, such as heat, electricity, and light, mechanochemistry focuses on the activation of chemical reactions by directly or indirectly applying mechanical forces. It has evolved as a powerful tool for controlling chemical reactions in solid state systems, sensing and responding to stresses in polymer materials, regulating interfacial adhesions, and stimulating biological processes. By combining theoretical approaches, simulations and experimental techniques, researchers have gained intricate insights into the mechanisms underlying mechanochemistry. In this review, the physical chemistry principles underpinning mechanochemistry are elucidated and a comprehensive overview of recent significant achievements in the discovery of mechanically responsive chemical processes is provided, with a particular emphasis on their applications in materials science. Additionally, The perspectives and insights into potential future directions for this exciting research field are offered.

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Bioprinting of hepatic tissue using 3D technology: Transitioning beyond laboratory models to real-world applications in medical treatments

Kumar,

Malviya

2024

Applied Materials Today

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Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation

Cited by 6 publications

References 99 publications

3D Printed Porous Okara-Based Sponge with Hemostatic and Antimicrobial Effects for Wound Healing

3D Printed Porous Okara-Based Sponge with Hemostatic and Antimicrobial Effects for Wound Healing

Mechanochemistry: Fundamental Principles and Applications

Bioprinting of hepatic tissue using 3D technology: Transitioning beyond laboratory models to real-world applications in medical treatments

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