Long-term Histological and Scanning Electron Microscopy Results of Endovascular and Operative Treatments of Experimentally Induced Aneurysms in the Rabbit

Krings, Timo; Busch, Claudia; Sellhaus, Bernd; Drexler, A.Y.; Bovi, Manfred; Hermanns-Sachweh, Benita; Scherer, K.; Gilsbach, Joachim M.; Thron, A.; Hans, Franz-Josef

doi:10.1227/01.neu.0000232841.08876.da

Cited by 23 publications

(20 citation statements)

References 51 publications

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“…68 Many investigators have published scales that offer a rational, if not a validated basis, for assessing the performance of an implant, by giving points for features considered favorable for healing, including neck coverage with neointima, thickness of neointimal layer, or clot organization at the dome. 11,19,[43][44][45][46][47]56,69 These semiquantitative scales have largely been confined to single-center experiences; they have not been reproduced or validated. No one, to our knowledge, has been able to show that these criteria predict better in vivo clinical performances, however.…”

Section: Discussionmentioning

confidence: 99%

“…8,18,30,31 Microscopic recurrences have been described with the rabbit elastase model, but a correlation with angiographic recurrences is rarely possible. 45,49,50 Nevertheless, characteristics of the healing of experimental aneurysms, mainly gleaned from cross-species comparisons, have been described. These studies have uniformly revealed organization of the thrombus within the aneurysmal sac within 6 months of platinum coil embolization of surgically created aneurysms in canines and swine, as well as neointimal coverage of the ostium of occluded aneurysms.…”

Section: Pathologic Analyses Of Treated Aneurysmsmentioning

confidence: 99%

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In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY: Animal models are necessary to develop and test innovations in aneurysm therapy before clinical introduction. This review aims at identifying the most likely candidates for standardizing preclinical testing of aneurysm devices. We systematically searched electronic databases for publications on animal aneurysm models from 1961-2008 to assess the methodologic quality of the studies and collect data on the patency and angiographic and pathologic outcomes of treatments. There has been a steady increase in the annual number of publications with time. Species that were most frequently used were dogs, rabbits, and rodents, followed by swine. Most publications are single-laboratory studies with variables and poorly validated outcome measures, a small number of subjects, and limited standardization of techniques. The most appropriate models to test for recurrences after endovascular occlusion were the surgical bifurcation model in dogs, and the elastase-induced aneurysm model in rabbits. A standardized multicenter study is needed to improve the preclinical evaluation of endovascular devices in aneurysm therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Pathologic Analyses Of Treated Aneurysmsmentioning

confidence: 99%

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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show abstract

“…Many researchers focused on "deficient healing," alternatively considered as deficient fibrosis, 5,6 lack of endothelialization, 7 or insufficient neointima formation. 8 Recurrences can be explained, we will argue, without resorting to such concepts.…”

mentioning

confidence: 99%

Mechanisms of Occlusion and Recanalization in Canine Carotid Bifurcation Aneurysms Embolized with Platinum Coils: An Alternative Concept

Raymond¹,

Darsaut²,

Salazkin³

et al. 2008

AJNR Am J Neuroradiol

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“…Krings et al 51 tested stent assisted coiling and found that porous stents resulted in higher rates of aneurysm recanalization than covered stents. In addition, Krings et al 52 demonstrated comparable rates of in-stent stenosis with those seen in human aneurysms treated with stent assisted coiling. As mentioned above, the curvature of the parent vessel of the rabbit elastase aneurysm allows for accurate characterization of intra-aneurysm flow dynamics both before and after treatment.…”

Section: Device Testingmentioning

confidence: 89%

From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment

Brinjikji

Ding

Kallmes

et al. 2015

J NeuroIntervent Surg

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Summary Pre-clinical studies are important in helping practitioners and device developers improve techniques and tools for endovascular treatment of intracranial aneurysms. Thus, an understanding of the major animal models used in such studies is important. The New Zealand rabbit elastase induced arterial aneurysm of the common carotid artery is one of the most commonly used models in testing the safety and efficacy of new endovascular devices. In this review we discuss 1) various techniques used to create the aneurysm, 2) complications of aneurysm creation, 3) natural history of the arterial aneurysm, 4) histopathologic and hemodynamic features of the aneurysm 5) devices tested using this model and 6) weaknesses of the model. We demonstrate how pre-clinical studies using this model are applied in treatment of intracranial aneurysms in humans. The model has a similar hemodynamic, morphological and histologic characteristics to human aneurysms and demonstrates similar healing responses to coiling as human aneurysms. Despite these strengths however, the model does have many weaknesses including the fact that the model does not emulate the complex inflammatory processes affecting growing and ruptured aneurysms. Furthermore the model’s extracranial location affects its ability to be used in preclinical safety assessments of new devices. We conclude that the rabbit elastase model has characteristics that make it a simple and effective model for preclinical studies on the endovascular treatment of intracranial aneurysms however further work is needed to develop aneurysm models that simulate the histopathologic and morphologic characteristics of growing and ruptured aneurysms.

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Long-term Histological and Scanning Electron Microscopy Results of Endovascular and Operative Treatments of Experimentally Induced Aneurysms in the Rabbit

Cited by 23 publications

References 51 publications

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Mechanisms of Occlusion and Recanalization in Canine Carotid Bifurcation Aneurysms Embolized with Platinum Coils: An Alternative Concept

From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment

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