1996
DOI: 10.1016/0300-2977(96)89606-9
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Long-term immunity to hepatitis B infection after vaccination with recombinant hepatitis B vaccine

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“…Long‐term B‐cell memory has been confirmed by demonstrating either the presence of anamnestic anti‐HBs responses, or the presence of circulating B cells to produce anti‐HBs by a spot‐enzyme‐linked immunosorbent assay (ELISA). Thus, among 456 hospital employees in the Netherlands, who were followed up for up to 15 years, although 30% had no detectable anti‐HBs, all had either B‐cell memory by spot ELISA, or an anamnestic response following the administration of a further dose of HB vaccine [26]. The spot ELISA is an in vitro technique for detecting the ability of circulating B cells to produce anti‐HBs [27].…”
Section: The Role Of Immunological Memorymentioning
confidence: 99%
“…Long‐term B‐cell memory has been confirmed by demonstrating either the presence of anamnestic anti‐HBs responses, or the presence of circulating B cells to produce anti‐HBs by a spot‐enzyme‐linked immunosorbent assay (ELISA). Thus, among 456 hospital employees in the Netherlands, who were followed up for up to 15 years, although 30% had no detectable anti‐HBs, all had either B‐cell memory by spot ELISA, or an anamnestic response following the administration of a further dose of HB vaccine [26]. The spot ELISA is an in vitro technique for detecting the ability of circulating B cells to produce anti‐HBs [27].…”
Section: The Role Of Immunological Memorymentioning
confidence: 99%