Long‐term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia

Abstract

Lenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long-term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient-specific primers. A 20-yr-old patient with standard-risk CLL was treated with lenalidomide after multiple relapses and achieved a 4 yr long complete molecular response with minimal toxicities. Published biologic data support that lenalidomide induces an immune-mediated control of CLL, and our case suggests that long-term treatment with lenalidomide is effective at a molecular level in patients with relapsed CLL.

Combination of bendamustine and rituximab in the management of relapsed and refractory chronic lymphocytic leukemia: the results of retrospective study

“…По данным нашего исследова-ния, поддерживающая терапия ритуксимабом назна-чалась в рамках рутинной практики части пациентов (37,2 %), но оценить эффект от ее применения не представляется возможным. Иммуномодулирующий агент леналидомид тестируется в качестве возможной опции для поддерживающего лечения ХЛЛ, однако окончательные результаты пока не доступны [20].…”