Long-term mouse spinal cord organotypic slice culture as a platform for validating cell transplantation in spinal cord injury
Francesca Merighi,
Sara De Vincentiis,
Marco Onorati
et al.
Abstract:Spinal cord injury (SCI) is an extremely invalidating condition with a severe physical and psychological impact. Resolutive cures are still lacking, due to its complex pathophysiology. One of the most promising regenerative approaches is based on stem cell transplantation to replace lost tissue and promote functional recovery. This approach should be explored better in vitro and ex vivo for safety and efficacy before proceeding with more expensive and time-consuming animal testing. In this work, we show the es… Show more
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