Long-term nitric oxide release for rapid endothelialization in expanded polytetrafluoroethylene small-diameter artificial blood vessel grafts

Wang, Dongfang; Xu, Yiyang; Wang, Lixia; Wang, Xiaofeng; Yan, Shujie; Yilmaz, Galip; Li, Qian; Turng, Lih‐Sheng

doi:10.1016/j.apsusc.2019.145028

Cited by 38 publications

(18 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Immobilization of serum albumin and a peptide aptamer for endothelial progenitor cells (EPC) via polydopamine significantly improved EPC adhesion and simultaneously reduced platelet adhesion and fibrinogen adsorption in vitro [ 77 ]. Likewise, ePTFE functionalized with polydopamine and coupled to an NO catalyst and VEGF increased NO production, promoted EC proliferation, and prevented platelet adhesion [ 78 ]. Coimmobilization of the antithrombotic peptide ACH11 and Cys-Ala-Gly (CAG), a tripeptide present in collagen type IV of the EBM, was shown to have a selective affinity for EC but not for SMC, thus reducing the risk for vessel narrowing due to excessive SMC proliferation (intimal hyperplasia).…”

Section: Strategies To Generate or Mimic Endothelial Basement Membranesmentioning

confidence: 99%

Designing Cardiovascular Implants Taking in View the Endothelial Basement Membrane

Lau

Gossen

Lendlein

2021

IJMS

View full text Add to dashboard Cite

Insufficient endothelialization of cardiovascular grafts is a major hurdle in vascular surgery and regenerative medicine, bearing a risk for early graft thrombosis. Neither of the numerous strategies pursued to solve these problems were conclusive. Endothelialization is regulated by the endothelial basement membrane (EBM), a highly specialized part of the vascular extracellular matrix. Thus, a detailed understanding of the structure–function interrelations of the EBM components is fundamental for designing biomimetic materials aiming to mimic EBM functions. In this review, a detailed description of the structure and functions of the EBM are provided, including the luminal and abluminal interactions with adjacent cell types, such as vascular smooth muscle cells. Moreover, in vivo as well as in vitro strategies to build or renew EBM are summarized and critically discussed. The spectrum of methods includes vessel decellularization and implant biofunctionalization strategies as well as tissue engineering-based approaches and bioprinting. Finally, the limitations of these methods are highlighted, and future directions are suggested to help improve future design strategies for EBM-inspired materials in the cardiovascular field.

show abstract

Section: Strategies To Generate or Mimic Endothelial Basement Membranesmentioning

confidence: 99%

Designing Cardiovascular Implants Taking in View the Endothelial Basement Membrane

Lau

Gossen

Lendlein

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…The pure polyester fabric contains C and O elements, while the coating fabrics exhibited three peaks at the binding energies of 535, 404, and 284 eV, which were attributed to O, N, and C elements, respectively. This was due to the introduction of N element when the pure polyester fabric was coated [ 11 , 44 , 45 ]. The XPS survey spectra spectrum of before and after coating fabrics were shown in Figure 3 B.…”

Section: Resultsmentioning

confidence: 99%

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

et al. 2022

View full text Add to dashboard Cite

Medical apparatus and instruments, such as vascular grafts, are first exposed to blood when they are implanted. Therefore, blood compatibility is considered to be the critical issue when constructing a vascular graft. In this regard, the coating method is verified to be an effective and simple approach to improve the blood compatibility as well as prevent the grafts from blood leakage. In this study, polyester fabric is chosen as the substrate to provide excellent mechanical properties while a coating layer of polyurethane is introduced to prevent the blood leakage. Furthermore, gelatin is coated on the substrate to mimic the native extracellular matrix together with the improvement of biocompatibility. XPS and FTIR analysis are performed for elemental and group analysis to determine the successful coating of polyurethane and gelatin on the polyester fabrics. In terms of blood compatibility, hemolysis and platelet adhesion are measured to investigate the anticoagulation performance. In vitro cell experiments also indicate that endothelial cells show good proliferation and morphology on the polyester fabric modified with such coating layers. Taken together, such polyester fabric coated with polyurethane and gelatin layers would have a promising potential in constructing vascular grafts with expected blood compatibility and biocompatibility without destroying the basic mechanical requirements for vascular applications.

show abstract

“…Therefore, the modification of the ePTFE surface to improve endothelial cell attachment attracted attention recently. A majority of performed studies use growth factor delivery systems, distinct adhesion molecule immobilization or synthetic coatings to enhance endothelial cell attachment and proliferation [ [26] , [27] , [28] , [29] , [56] , [57] , [58] , [59] ]. However, there are still existing drawbacks with these modification methods.…”

Section: Discussionmentioning

confidence: 99%

Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts

Rohringer

Schneider

Eder

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

Long-term nitric oxide release for rapid endothelialization in expanded polytetrafluoroethylene small-diameter artificial blood vessel grafts

Cited by 38 publications

References 41 publications

Designing Cardiovascular Implants Taking in View the Endothelial Basement Membrane

Designing Cardiovascular Implants Taking in View the Endothelial Basement Membrane

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts

Contact Info

Product

Resources

About