Long-term odor recognition memory in unipolar major depression and Alzheimer׳s disease

Naudin, Marine; Mondon, Karl; El‐Hage, Wissam; Desmidt, Thomas; Jaafari, Nématollah; Belzung, Catherine; Gaillard, Philippe; Hommet, Caroline; Atanasova, Boriana

doi:10.1016/j.psychres.2014.08.050

Cited by 28 publications

(25 citation statements)

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“…The olfactory function may be also altered in some neurological and metabolic disorders. Olfactory memory is affected in Alzheimer's disease [16]. Lietzau et al showed that type 2 diabetes may impair olfactory memory and odor detection and decreases neurogenesis in the olfactory bulb [17].…”

Section: Introductionmentioning

confidence: 99%

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Olfactory Memory in Depression: State and Trait Differences between Bipolar and Unipolar Disorders

Kazour

Richa

Char³

et al. 2020

Brain Sciences

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Background: Changes in olfactory recognition memory may constitute sensory markers in depression. Significant differences may exist between unipolar and bipolar depression. Our study compares olfactory memory between control, unipolar, and bipolar patients in depressed and euthymic states in order to identify potential markers of depression. Methods: 176 participants were recruited in 5 groups: depressed bipolar (DB), euthymic bipolar (EB), depressed unipolar (DU), euthymic unipolar (EU), and controls (HC). The participants had a standardized clinical and olfactory assessment (olfactory memory, evaluation of pleasantness, intensity, familiarity, and emotional aspect of smells). Results: DU, DB, and EU patients had a deficit in olfactory memory compared to HC. DB patients had lower capacity to recognize new odors. DB and DU patients had more limited detection of unfamiliar odors than HC. DB patients rated odors as less pleasant compared to the other groups. All groups had lower hedonic ratings than HC. DB patients had lower emotional ratings than EU patients. Conclusions: Olfactory memory is impaired in depressive states, thus constituting a state marker of depression. Impairments in olfactory memory persist after remission of bipolar depression, thus constituting a possible trait marker of bipolarity. Hedonic rating differentiates unipolar from bipolar depression. This is the first study that identifies a sensory marker differentiating between unipolar and bipolar depression.

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Section: Introductionmentioning

confidence: 99%

“…Olfactory recognition memory may be also affected by depression. Indeed, olfactory memory is more associated with emotions than auditory and visual memories [16,22]. According to Koster et al, olfactory perception and memory are implicitly associated with the emotional and hedonic rating of the environment.…”

Section: Introductionmentioning

confidence: 99%

Olfactory Memory in Depression: State and Trait Differences between Bipolar and Unipolar Disorders

Kazour

Richa

Char³

et al. 2020

Brain Sciences

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“…However, these two categories of patients differ in the nature of the olfactory disorder, studies comparing odor identification performance between patients AD and patients with depression have reported most important alterations in AD compared to patients with depression (McCaffrey et al, 2000;Pentzek et al, 2007;Solomon et al, 1998). Recent studies have shown the potential interest of olfactory tests to aid in early diagnosis of these diseases (Naudin et al, 2014). Concerning, autistic spectrum disorder, subjects have also been shown to be significantly less accurate than controls in olfactory identification tests (Bennetto et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

An odor identification approach based on event-related pupil dilation and gaze focus

Aguillon‐Hernandez

Naudin

Roché

et al. 2015

International Journal of Psychophysiology

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“…No problems with smell identification and recognition is diagnosed in this patient group [51,52]. For that reason, olfactory tests are considered useful tools, which enable one to successfully distinguish between patients at risk for the disease or suffering from AD from healthy individuals and individuals suffering from Major Depression from those with depression in the course of AD [31,53].…”

Section: Związek Sprawności Węchowej I Sprawności Poznawczejmentioning

confidence: 99%

“…W przypadku pacjentów chorujących na depresję, którzy mogą zgłaszać objawy poznawcze przypominające MCI lub nawet łagodne stadium AD, stwierdza się również pewne obniżenie wrażliwości na zapachy, które łatwo ulega poprawie po terapii antydepresyjnej (zdolności identyfikacji i rozróżniania zapachów są praktycznie nienaruszone) [51,52]. Z tego względu uważa się, że za pomocą testów sprawności węchowej można z powodzeniem odróżniać pacjentów zagrożonych lub chorujących na AD od osób zdrowych oraz osoby chorujące na depresję od osób z depresją w przebiegu AD [31,53].…”

Section: Specificity Of the Olfactory Impairment In Alzheimer's Diseaseunclassified

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Śmigórska¹,

Śmigórski²

2017

ppn

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Purpose: The aim of this article is to provide a summary of findings concerning olfactory loss associated with pathological neurodegenerative changes which occur over the course of Alzheimer's disease. Views: It is shown that compared with the healthy population, olfactory dysfunction is more pronounced in neurodegenerative diseases and precedes symptoms typical of those diseases. One of the primary differences between physiological, age-associated and pathological olfactory loss is the patients' awareness of the deficit. Healthy hyposmic or even anosmic patients are often aware of the problems caused by this dysfunction; however, it is not the case for patients in the preclinical, prodromal or clinical stages of Alzheimer's disease. Conclusions:The clinical value of olfactory function assessments should be emphasized, as it may provide information about the potential prodromal symptoms of Alzheimer's disease. Key words: Alzheimer's disease, olfaction disorders, olfactory perception, dementia, smell. StreszczenieCel: Celem pracy jest przedstawienie stanu wiedzy na temat utraty sprawności węchowej związanej z patologicznymi zmianami neurozwyrodnieniowymi zachodzącymi w przebiegu choroby Alzheimera. Poglądy: Przedstawiono dane wskazujące, że u osób cierpiących na choroby neurozwyrodnieniowe zaburzenia sprawności węcho-wej są bardziej nasilone w porównaniu ze zdrową populacją i poprzedzają objawy typowe dla tych chorób. Jedną z głównych różnic między fizjologiczną, związaną z wiekiem a patologiczną utratą węchu jest świadomość deficytu. Zdrowi, hipozmiczni lub nawet anozmiczni pacjenci są często świadomi problemów powodowanych przez dysfunkcję węchową, czego często nie stwierdza się w przypadku pacjentów w przedklinicznym, prodromalnym lub klinicznym stadium choroby Alzheimera.Wnioski: Podkreślono wartość kliniczną badania sprawności węchu jako potencjalnego objawu prodromalnego choroby Alzheimera. Słowa kluczowe: choroba Alzheimera, zaburzenia węchu, percepcja olfaktoryczna, otępienie, węch.

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Long-term odor recognition memory in unipolar major depression and Alzheimer׳s disease

Cited by 28 publications

References 40 publications

Olfactory Memory in Depression: State and Trait Differences between Bipolar and Unipolar Disorders

Olfactory Memory in Depression: State and Trait Differences between Bipolar and Unipolar Disorders

An odor identification approach based on event-related pupil dilation and gaze focus

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

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