Long-Term Pacemaker Dependency Following Implantation with the LOTUS Transcatheter Aortic Valve

Alasti, Mohammad; Kotschet, Emily; Rangasamy, Karthikeyan; Rashid, H.; Adam, David; Gooley, Robert; Alison, J.; Zaman, Sarah

doi:10.1016/j.hlc.2017.06.324

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“…In addition, more than half of the patients implanted with a PPM after TAVR were not pacemaker dependent, while pacemaker dependency is a predictor of heart failure. 40…”

Section: Discussionmentioning

confidence: 99%

Impact of postprocedural permanent pacemaker implantation on clinical outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis

Liu

Liang

et al. 2019

Preprint

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Background: The incidence of conduction disturbances requiring permanent pacemaker (PPM) implantation following transcatheter aortic valve replacement (TAVR) have remained a common concern. The purpose of this study was to evaluate the impact of postprocedural PPM implantation following TAVR on clinical outcomes. Methods: We performed a systematic search in PubMed and EMBASE databases for studies that reported raw data on clinical outcomes of patients with and without PPM implantation after TAVR and followed up patients for 10 months or longer. The primary endpoint was all-cause death. The secondary endpoints were cardiovascular death, heart failure and a composite of stroke and myocardial infarction (MI). Results: Data from 20 studies with a total of 21666 patients undergoing TAVR, of whom 12.5% required PPM implantation after intervention, were analysed and the mean duration follow-up was 16.9 months. The rate of PPM ranged from 6.2% to 32.8% among different studies. A total of 6753 (31.2%) patients underwent TAVR with self-expandable prosthesis and 14913 (68.8%) with balloon-expandable prosthesis. The incidence of postprocedural PPM implantation was higher with the self-expandable prosthesis (n=1717, 25.4%) compared with the balloon-expandable prosthesis (n=996, 6.7%). PPM after TAVR was associated with a higher risk of all-cause death (RR: 1.13; 95% CI: 1.01-1.25; P=0.03) but not incidence of stroke and MI (RR: 0.85; 95% CI: 0.64-1.13; P=0.27). Conclusions: In patients undergoing TAVR, the PPM implantation after intervention was associated higher all-cause mortality but not cardiovascular mortality, heart failure and stroke or MI, which remain an unsolved issue of TAVR.

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“…In addition, more than half of the patients implanted with a PPM after TAVR were not pacemaker dependent, while pacemaker dependency is a predictor of heart failure. 40…”

Section: Discussionmentioning

confidence: 99%

Impact of postprocedural permanent pacemaker implantation on clinical outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis

Liu

Liang

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

Long-Term Pacemaker Dependency Following Implantation with the LOTUS Transcatheter Aortic Valve

Cited by 1 publication

References 0 publications

Impact of postprocedural permanent pacemaker implantation on clinical outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis

Impact of postprocedural permanent pacemaker implantation on clinical outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis

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