Long term performance of small-diameter vascular grafts made of a poly(ether)urethane–polydimethylsiloxane semi-interpenetrating polymeric network

Soldani, Giorgio; Losi, Paola; Bernabei, Massimo; Burchielli, Silvia; Chiappino, Dante; Kull, Silvia; Briganti, Enrica; Spiller, Dario

doi:10.1016/j.biomaterials.2009.12.017

Cited by 106 publications

(74 citation statements)

References 43 publications

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“…They are serious problems especially for small diameter artificial vascular grafts. [22][23][24][25][26] To improve graft patency, thrombus formation and neointimal hyperplasia should be controlled. Early stage endothelialisation offers a potential solution.…”

Section: Discussionmentioning

confidence: 99%

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Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

et al. 2015

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ABSTRACT. Vascular grafts under 5 mm or less in diameter are not developed due to a problem caused by early thrombus formation, neointimal hyperplasia, etc. Bombyx mori silk fibroin (SF) which has biodegradability and tissue infiltration is focused as tube and coating material of vascular grafts. Coating is an important factor to maintain the strength of the anastomotic region of vascular grafts, and to prevent the blood leak from the vascular grafts after implantation. Therefore, in this research, we focused on the SF concentration of the coating solution, and tissue infiltration and remodeling were compared among each SF concentration. Silk poly (-ethylene) glycol diglycidyl ether (PGDE) coating with concentrations of 1.0%, 2.5%, 5.0%, and 7.5% SF were applied for the double-raschel knitted small-sized vessel with 1.5 mm diameter and 1cm in length. The grafts were implanted in the rat abdominal aorta and removed after 3 weeks or 3 months. Vascular grafts patency was monitored by ultrasound, and morphological evaluation was performed by histopathological examination. SF concentration had no significant effects on the patency rate. However, tissue infiltration was significantly higher in the sample of 2.5% SF in 3 weeks, and 1.0% and 2.5% SF in 3 months. Also, in comparison of length inside of the graft, stenosis were not found in 3 weeks, however, found with 5.0% and 7.5% in 3 months. From these results, it is clear that 2.5% SF coating is the most suitable concentration, based on the characteristics of less stenosis, early tissue infiltration, and less neointimal hyperplasia.

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Section: Discussionmentioning

confidence: 99%

“…22,35,36 The inside length of the graft was divided by p to measure the diameters of the 4 graft types at 3 weeks and 3 months after implantation. This value was regarded as the degree of intimal hyperplasia.…”

Section: Imaging Analysismentioning

confidence: 99%

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

et al. 2015

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“…In recent years, siliconebased elastomers have been used in a wide range of biomedical applications due to their good blood compatibility, low toxicity, good thermal and oxidative stability, low modulus and anti-adhesive properties [27,28] Our laboratory previously developed a versatile elastomeric formulation that, in the form of a semi-interpenetrating polymeric network (semi-IPN), combines in one step the already-proven good properties of the aforementioned PUs and silicone materials [29]. The PEtUePDMS semi-IPN has been tested in preclinical applications in form of small-diameter vascular grafts [30] and for the coating of abdominal meshes [31] with relevant results regarding graft patency and the absence of adhesion formation, respectively.…”

Section: Introductionmentioning

confidence: 99%

Tissue response to poly(ether)urethane-polydimethylsiloxane-fibrin composite scaffolds for controlled delivery of pro-angiogenic growth factors

et al. 2010

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“…Dacron has been used as an alternative to autologous grafts, but it has shown poor patency rates when used in smalldiameter sizes or in low-flow locations [15]. In 1976, Sauvage reported a successful adult case with a knitted Dacron vascular graft (4 cm long and 3.5 mm in diameter) between the aorta and right coronary artery [16].…”

Section: Dacronmentioning

confidence: 99%

Role of prosthetic conduits in coronary artery bypass grafting

Desai

Seifalian

Hamilton

2011

European Journal of Cardio-Thoracic Surgery

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Prosthetic grafts are required for coronary artery bypass grafting (CABG) when the availability of suitable autologous conduits is limited. The ideal cardiovascular bypass graft requires a broad range of characteristics including strength, viscoelasticity, biocompatibility, blood compatibility and biostability. Many alternative conduits have been developed and used in the past, but most of them have failed, except in rare instances. This review aims to analyse the current status of their use and prospects for the future. We performed a literature search on PubMed using the generic terms 'conduits for coronary artery bypass grafting'; 'reoperative coronary artery bypass grafting'; 'redo coronary artery bypass grafting'; 'PTFE'; 'Dacron or PET'; 'gastroepiploic artery'; 'inferior epigastric artery'; 'biological grafts'; 'tissue-engineered grafts'; 'synthetic grafts'; 'prosthetic grafts'; 'polyurethane grafts'; 'cephalic veins'; 'short saphenous vein;' and 'alternative conduits'. In addition, we searched through related citations and references from selected articles. A total of 1253 references and 110 full-text articles were reviewed, and they were further selected based on available information. This review concludes that, over the past three to four decades, achieving the goal of a prosthetic graft with equivalent function and durability to the internal mammary artery or long saphenous vein has proved to be elusive.

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Long term performance of small-diameter vascular grafts made of a poly(ether)urethane–polydimethylsiloxane semi-interpenetrating polymeric network

Cited by 106 publications

References 43 publications

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

Tissue response to poly(ether)urethane-polydimethylsiloxane-fibrin composite scaffolds for controlled delivery of pro-angiogenic growth factors

Role of prosthetic conduits in coronary artery bypass grafting

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