Long-Term Prognosis of Moderate to Severe Coronary Artery Calcification in Patients Undergoing Percutaneous Coronary Intervention

Jia, Sida; Li, Jianxin; Zhang, Ce; Liu, Yue; Yuan, Deshan; Xu, Na; Zhao, Xueyan; Gao, Runlin; Yang, Yuejin; Xu, Bo; Gao, Zhan; Yuan, Jinqing; Yin, Zhang

doi:10.1253/circj.cj-20-0761

Cited by 8 publications

(8 citation statements)

References 28 publications

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“… 15 Domestic scholars have confirmed that moderate to severe CAC in patients undergoing percutaneous coronary intervention is an independent risk factor for long-term major adverse cardiovascular events (HR=1.242; P = 0.017). 16 However, few serological markers can effectively predict CAC.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Wang¹,

Hua²,

2022

Pak J Med Sci

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Objectives: We assessed the TG/HDL-C ratio as a predictor for the presence of coronary artery calcifications (CACs). Methods: We collected demographic characteristics (age and gender), physical examination (height, weight, BMI, SBP, DBP), comorbidities, medication use, and laboratory variables Triglyceride to High-Density Lipoprotein (TG, HDL-C, TG/HDL-C, UA, TBG, 25-OH-VitD3); and we used coronary angiography to determine the presence of CACs. We performed univariate and multivariate analyses to evaluate the correlation between the TG/HDL-C ratio and CACs and established a predictive model. Results: CAC was present in 121 patients (25.80%). The levels of TG and TG/HDL-C ratio in the CAC group were higher than those in the non-CAC group, while the level of HDL-C in the CAC group was lower than that in the non-CAC group. The univariate analysis showed that the TG/HDL-C ratio was associated with CAC (OR, 0.021; 95% CI, 0.008 to 0.052; P<0.001), and the multivariate analysis indicated that the ratio was an independent risk factor for CAC (OR, 4.088; 95% CI, 2.787-5.996; P<0.001). Using the ratio to establish a prediction model, the area under the ROC curve was 0.814 (95% CI, 0.775-0.853; P<0.001), suggesting that the TG/HDL-C ratio has a high diagnostic efficiency. The diagnostic threshold was 1.037, and the corresponding sensitivity and specificity were 89.3% and 60.5%, respectively. Conclusion: The Triglyceride to High-Density Lipoprotein TG/HDL-C ratio is an independent risk factor for CAC with good diagnostic efficacy. Abbreviations: TG: Triglycerides, HDL-C: High-Density Lipoprotein, CAC: Coronary Artery Calcifications, BMI: Body Mass Index, SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, UA: Uric Acid, FBG: Fasting Blood Glucose, 25-OH-VitD3: 25-Hydroxyvitamin D3, ACEI: Angiotensin-Converting Enzyme Inhibitors, ARB: Angiotensin Receptor Blockers, CCB: Calcium Channel Blockers, ARNI: Angiotensin Receptor-Neprilysin Inhibitor, CAG: Coronary Angiography, AUCROC: Area Under the Receiver Operating Curve. doi: https://doi.org/10.12669/pjms.38.3.5290 How to cite this:Wang B, Hua J, Ma L. Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5290 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Wang¹,

Hua²,

2022

Pak J Med Sci

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“…In previous studies, calcified lesions were stratified by radiopacity and mobility [6][7][8][9]19]. However, the exact calcific extent and distribution that could affect stent expansion and worsen long-term outcomes in such balloon dilatable lesions are still less understood [20].…”

Section: Discordancementioning

confidence: 99%

“…CB is likely to be an underused and potentially useful adjunct in calcium modification [1]. However, the outcomes in the patients with calcified lesions that were treated by cutting balloons were less studied [5][6][7]. It is important to investigate the unique prognostic impact of CBs on calcified lesions.…”

Section: Introductionmentioning

confidence: 99%

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3-Year outcomes in patients with heavily calcified lesions undergoing percutaneous coronary intervention using cutting balloons

Liu

Yao

Jiang

et al. 2022

BMC Cardiovasc Disord

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Background Percutaneous coronary intervention (PCI) of heavily calcified lesions (HCLs) is associated with higher complication rates and worse clinical outcomes. Cutting balloon (CB) has been widely used for HCLs, but patients’ prognosis had not been fully clarified. The study aimed to compare 3-year clinical outcomes between patients with HCLs that are treated with CBs and those with non-HCLs. Method Patients who underwent PCI in Guizhou Provincial People’s Hospital from June 2015 to September 2018 were retrospectively included. HCL was defined as radiopaque and high-pressure undilatable lesions. CBs were routinely used in combination with non-compliant balloons for the HCLs. Major adverse cardiac event (MACE) and target vessel failure (TVF) were assessed at 3-year follow-up. Result Among 2432 patients included in the study, 210(8.6%) had HCLs with a procedural success rate of 91.0%. The patients with HCLs had a higher incidence of MACE (23.3% vs. 10.8%, P < 0.001) than those with non-HCLs. By propensity score matching, 172 patients with HCLs were 1:1 paired to those with non-HCLs, and their PCI vessels were exactly matched. The MACE and TVF were significantly higher in the patients with HCLs than those with non-HCLs (MACE: 21.5% vs. 13.4%, P = 0.036; TVF: 19.8% vs. 9.9%, P = 0.008). In the Cox regression analysis, HCL is independently associated with higher risks of MACE [HR: 1.72(1.01–2.94), P = 0.047], TVF [HR: 2.10(1.15–3.81), P = 0.015] and repeat revascularization [HR: 2.20(1.07–4.52), P = 0.032]. Conclusion Patients with HCLs undergoing PCI using CBs in combination with non-compliant balloons had higher risks of complications, procedural failure, and worse clinical outcomes at 3 years than those with non-HCLs.

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“…Based on the analysis of burst keywords, we speculated that endovascular intervention measures for VC will become an emerging academic trend in VC research. These measures included minimally invasive transcatheter valve replacement for aortic valve or heart valve stenosis (Ielasi et al, 2021), percutaneous coronary intervention for coronary artery calcification (Jia et al, 2020), and intravascular lithotripsy (Dini et al, 2019) for peripheral arterial disease. Concurrently, signal transduction pathways have been found to play a significant role in VC occurrence and progression.…”

Section: Hotspots and Frontiersmentioning

confidence: 99%

Bibliometric and Visual Analysis of Vascular Calcification Research

et al. 2021

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Background: Extensive studies related to vascular calcification (VC) were conducted in recent years. However, no bibliometric analysis has systematically investigated this topic. Our study aimed to determine the hotspots and frontiers of VC research in the past decade and provide a reference for future scientific research directions and decision-making in the VC field.Methods: VC studies were acquired from the Web of Science Core Collection. Bibliometric and visual analyses were performed using CiteSpace, VOSviewer, and Microsoft Excel software.Results: A total of 8,238 English articles on VC research published in 2011–2020 were obtained. In the past decade, annual publications and citations showed a significant growth trend, especially in 2018–2020. The most productive country, institution, journal and author are the United States, the University of California System, PLOS ONE, and Budoff MJ, respectively. The most frequently cited country, journal, and author are the United States, Journal of the American College of Cardiology, and Floege J, respectively. “Vascular calcification,” “atherosclerosis,” “chronic kidney disease,” and “cardiovascular disease” are the primary keywords. The burst keywords “revascularization,” “calciprotein particle,” “microRNA,” and “microcalcification” are speculated to be the research frontiers.Conclusion: The main research hotspots in the VC field are the molecular mechanisms and prognosis of VC in patients with chronic kidney disease or cardiovascular disease. In addition, endovascular therapy and the development of new drugs targeting signal pathways for VC will become the focus of future research. Moreover, non-coding RNAs related to the diagnosis and treatment of VC are great research prospects.

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Long-Term Prognosis of Moderate to Severe Coronary Artery Calcification in Patients Undergoing Percutaneous Coronary Intervention

Cited by 8 publications

References 28 publications

Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

3-Year outcomes in patients with heavily calcified lesions undergoing percutaneous coronary intervention using cutting balloons

Bibliometric and Visual Analysis of Vascular Calcification Research

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