Long-term sero-positivity for IgG, sequelae of respiratory symptoms, and abundance of malformed sperms in a patient recovered from severe COVID-19

Zhu, Mingqing; Chen, Diliang; Zhu, Yun; Xiong, Xusheng; Ding, Yan; Guo, Feibo; Zhu, Minmin; Zhou, Junyang

doi:10.1007/s10096-021-04178-6

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…study by Zhu et al also reported long-term abnormal airway function for up to 11 months in a severe COVID-19 patient ( 44 ). However, because is a single case, this research does not provide conclusive evidence.…”

Section: Resultsmentioning

confidence: 84%

“…Differently, Latronico et al showed that since residual abnormal chest-X ray findings were detected in about 70% of critically ill COVID-19 patients at 3 months, very few of them (∼12%) had persisting respiratory symptoms at 6 months ( 27). An anecdotal study by Zhu et al also reported long-term abnormal airway function for up to 11 months in a severe COVID-19 patient (44). However, because is a single case, this research does not provide conclusive evidence.…”

Section: Persistent Lung Symptoms and Dysfunctionsmentioning

confidence: 72%

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Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

et al. 2021

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Whilst the entire world is battling the second wave of COVID-19, a substantial proportion of patients who have suffered from the condition in the past months are reporting symptoms that last for months after recovery, i. e., long-term COVID-19 symptoms. We aimed to assess the current evidence on the long-term symptoms in COVID-19 patients. We did a systematic review on PubMed, Web of Science, EMBASE, and Google Scholar from database inception to February 15, 2021, for studies on long-term COVID-19 symptoms. We included all type of papers that reported at least one long-term COVID-19 symptom. We screened studies using a standardized data collection form and pooled data from published studies. Cohort cross-sectional, case-report, cases-series, case-control studies, and review were graded using specific quality assessment tools. Of 11,361 publications found following our initial search we assessed 218 full-text articles, of which 145 met all selection criteria. We found that 20.70% of reports on long-term COVID-19 symptoms were on abnormal lung functions, 24.13% on neurologic complaints and olfactory dysfunctions, and 55.17% on specific widespread symptoms, mainly chronic fatigue, and pain. Despite the relatively high heterogeneity of the reviewed studies, our findings highlighted that a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection present a “post-COVID syndrome.” The multifaceted understanding of all aspects of the COVID-19 pandemic, including these long-term symptoms, will allow us to respond to all the global health challenges, thus paving the way to a stronger public health.

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Section: Resultsmentioning

confidence: 84%

Section: Persistent Lung Symptoms and Dysfunctionsmentioning

confidence: 72%

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

et al. 2021

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“…Frequency of lung imaging abnormalities per different evaluation setting. References [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ] are cited in the Supplementary Materials…”

mentioning

confidence: 99%

A Systematic Review of Chest Imaging Findings in Long COVID Patients

Bazdar

Kwee

Houweling

et al. 2023

JPM

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Long COVID is the persistence of one or more COVID-19 symptoms after the initial viral infection, and there is evidence supporting its association with lung damage. In this systematic review, we provide an overview of lung imaging and its findings in long COVID patients. A PubMed search was performed on 29 September 2021, for English language studies in which lung imaging was performed in adults suffering from long COVID. Two independent researchers extracted the data. Our search identified 3130 articles, of which 31, representing the imaging findings of 342 long COVID patients, were retained. The most common imaging modality used was computed tomography (CT) (N = 249). A total of 29 different imaging findings were reported, which were broadly categorized into interstitial (fibrotic), pleural, airway, and other parenchymal abnormalities. A direct comparison between cases, in terms of residual lesions, was available for 148 patients, of whom 66 (44.6%) had normal CT findings. Although respiratory symptoms belong to the most common symptoms in long COVID patients, this is not necessarily linked to radiologically detectable lung damage. Therefore, more research is needed on the role of the various types of lung (and other organ) damage which may or may not occur in long COVID.

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“…Several alterations such as azoospermia, oligozoospermia, criptozoospermia and teratozoospermia were found ( 35 , 48 , 51 , 67 ). Gacci et al ( 35 ) reported that 25.6% of patients developed some of these alterations and that concentration of sperm was lower in more severely will patients.…”

Section: Resultsmentioning

confidence: 99%