Long-term Stability and in vitro Release of hPTH(1–34) from a Multi-reservoir Array

Proos, Elizabeth R.; Prescott, James H.; Staples, Mark

doi:10.1007/s11095-008-9544-0

Cited by 22 publications

(15 citation statements)

References 28 publications

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“…Similarly, an osteoporosis implant delivering pulsatile parathyroid hormone (PTH) was formulated at 500 mg/ml (~ 20 μg PTH/reservoir) and demonstrated good stability after 6 months at 37°C (Fig. 16) [99]. …”

Section: Implantable Deliverymentioning

confidence: 99%

Reservoir-based drug delivery systems utilizing microtechnology

Stevenson¹,

Santini²,

Langer

2012

Advanced Drug Delivery Reviews

203

126

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This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria. Reservoir-based systems include a subset of microfabricated drug delivery systems and provide unique advantages. Reservoirs, whether external to the body or implanted, provide a well-controlled environment for a drug formulation, allowing increased drug stability and prolonged delivery times. Reservoir systems have the flexibility to accommodate various delivery schemes, including zero order, pulsatile, and on demand dosing, as opposed to a standard sustained release profile. Furthermore, the development of reservoir-based systems for targeted delivery for difficult to treat applications (e.g., ocular) has resulted in potential platforms for patient therapy.

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Section: Implantable Deliverymentioning

confidence: 99%

Reservoir-based drug delivery systems utilizing microtechnology

Stevenson¹,

Santini²,

Langer

2012

Advanced Drug Delivery Reviews

203

126

View full text Add to dashboard Cite

show abstract

“…When a timed electrical current is applied to the sealed membrane, it disintegrates and releases the drug. 92-95 The device was first implanted in 8 osteoporotic women for the delivery of human parathyroid hormone fragment for 4 months with programmed release daily for 20 days. 96 The drug release of the device had similar pharmacokinetics as multiple injections of the medication, but displayed less variation and was well tolerated.…”

Section: Examples Of Mems Technologymentioning

confidence: 99%

Microelectromechanical Systems and Nephrology: The Next Frontier in Renal Replacement Technology

Kim

Roy

2013

Advances in Chronic Kidney Disease

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Microelectromechanical systems (MEMS) is playing a prominent role in the development of many new and innovative biomedical devices, but remains a relatively underutilized technology in nephrology. The future landscape of clinical medicine and research will only see further expansion of MEMS based technologies in device designs and applications. The enthusiasm stems from the ability to create small-scale device features with high precision in a cost effective manner. MEMS also offers the possibility to integrate multiple components into a single device. The adoption of MEMS has the potential to revolutionize how nephrologists manage kidney disease by improving the delivery of renal replacement therapies and enhancing the monitoring of physiologic parameters. To introduce nephrologists to MEMS, this review will first define relevant terms and describe the basic processes used to fabricate MEMS devices. Next, a survey of MEMS devices being developed for various biomedical applications will be illustrated with current examples. Finally, MEMS technology specific to nephrology will be highlighted and future applications will be examined. The adoption of MEMS offers novel avenues to improve the care of kidney disease patients and assist nephrologists in clinical practice. This review will serve as an introduction for nephrologists to the exciting world of MEMS.

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“…Conceptually similar to a drug pump, this device has in principle greater flexibility in both the material being delivered and the timing of that release. The Company is currently assessing a clinical study involving the release of long-term parathyroid hormone [42]. An alternative means is explored by Geipel et al [43] using a multiport injector, which would be appropriate in particular for very low-volume dispensing.…”

Section: Drug Release Implantsmentioning

confidence: 99%

Recent Advances in Translational Work on Implantable Sensors

Black

2011

IEEE Sensors J.

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This review evaluates example technologies from the point-of-view of likely translation into human use, including regulatory clearance, insertion into common medical practice and reimbursability. The intent is to highlight recent innovations in implantable sensors with a focus on the translational process itself in a holistic fashion. As well as looking at success stories, this review will also examine several seemingly promising technologies that have failed for reasons having nothing to do with the operational aspects of the sensors and systems involved. Innovation must be viewed as a multifaceted process, all segments of which must be fully addressed to achieve success. No party to the process can work in isolation and expect to achieve the end goal of providing new advances to patients. This review will have succeeded if it provides the reader with a better appreciation of the complex environment in which implantable sensor discoveries that seek to be translated into human medicine must navigate.Index Terms-Implantable sensors, sensor systems, in vivo medical devices.

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Long-term Stability and in vitro Release of hPTH(1–34) from a Multi-reservoir Array

Abstract: Clinically relevant formulations of hPTH(1-34) for use with implantable multi-reservoir devices are achievable.

Cited by 22 publications

References 28 publications

Reservoir-based drug delivery systems utilizing microtechnology

Reservoir-based drug delivery systems utilizing microtechnology

Microelectromechanical Systems and Nephrology: The Next Frontier in Renal Replacement Technology

Recent Advances in Translational Work on Implantable Sensors

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