2022
DOI: 10.3389/fimmu.2021.782935
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Long-Term Suppression of Circulating Proinflammatory Cytokines in Multiple Sclerosis Patients Following Autologous Haematopoietic Stem Cell Transplantation

Abstract: Autologous haematopoietic stem cell transplantation (AHSCT) is a therapeutic option for haematological malignancies, such as non-Hodgkin’s lymphoma (NHL), and more recently, for autoimmune diseases, such as treatment-refractory multiple sclerosis (MS). The immunological mechanisms underlying remission in MS patients following AHSCT likely involve an anti-inflammatory shift in the milieu of circulating cytokines. We hypothesised that immunological tolerance in MS patients post-AHSCT is reflected by an increase … Show more

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Cited by 6 publications
(1 citation statement)
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“…The use of live attenuated varicella vaccine as a possible adjunct therapy in the treatment of psoriasis could play a therapeutic role by regulating Th17/Treg balance [ 100 ]. Besides, autologous haematopoietic stem cell transplantation was critical for MS patients by inhibiting Th17 cytokines [ 101 ]. RA patients who had an inadequate response to conventional treatments were treated with Guluronic Acid, a new nonsteroidal anti-inflammatory drug, and the expression of the RORct gene was reduced [ 102 ].…”
Section: Discussionmentioning
confidence: 99%
“…The use of live attenuated varicella vaccine as a possible adjunct therapy in the treatment of psoriasis could play a therapeutic role by regulating Th17/Treg balance [ 100 ]. Besides, autologous haematopoietic stem cell transplantation was critical for MS patients by inhibiting Th17 cytokines [ 101 ]. RA patients who had an inadequate response to conventional treatments were treated with Guluronic Acid, a new nonsteroidal anti-inflammatory drug, and the expression of the RORct gene was reduced [ 102 ].…”
Section: Discussionmentioning
confidence: 99%