Long-term survival data and prognostic factors of a complete response to chemotherapy in patients with head and neck cancer treated with platinum-based induction chemotherapy: A hellenic co-operative oncology group study

Fountzilas, George; Kosmidis, P.; Avramidis, V.; Nikolaou, Angelos; Kalogera‐Fountzila, Anna; Makrantonakis, Paris; Bacoyiannis, C.; Samantas, Epaminontas; Skarlos, Dimosthenis; Daniilidis, J

doi:10.1002/(sici)1096-911x(199706)28:6<401::aid-mpo2>3.0.co;2-k

Cited by 20 publications

(8 citation statements)

References 37 publications

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“…However, scarce evidence is available on whether these risk factors interact with major treatment modalities in HNSCC. Fountzilas et al [ 8 ] reported that absence of smoking history was an important prognostic factor for complete response in 154 patients with locally advanced HNSCC receiving platinum-based induction chemotherapy. Kumar et al [ 10 ] demonstrated that a history of smoking was associated with a poor response to induction chemotherapy and a poor survival rate in patients with oropharyngeal cancer.…”

Section: Discussionmentioning

confidence: 99%

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Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Chien

Luo

et al. 2016

World J Surg Onc

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BackgroundSmoking and betel nut chewing are well-known risk factors for head and neck squamous cell carcinoma (HNSCC). Smoking is also a strong prognosticator for patients with locally advanced HNSCC receiving induction chemotherapy. Smoking with or without betel nut chewing is a common practice in Asia. However, little is known regarding whether betel nut chewing can serve as a prognostic factor for smoking patients with locally advanced HNSCC receiving induction chemotherapy. The aim of this study was to evaluate the prognostic impact of betel nut chewing in such patients receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF).MethodsFrom January 2010 to December 2012, we retrospectively analyzed 162 smoking patients with locally advanced HNSCC who received induction chemotherapy with TPF at our institution. Background characteristics, including a history of betel nut chewing, were analyzed as potential prognostic factors.ResultsAmong the 162 smoking patients, 131 patients (81 %) were betel nut chewers, while 31 (19 %) were non-betel nut chewers. One hundred fifty-six (96 %) were men, and 6 (4 %) were women. The median age was 53 years. The overall response rates to induction chemotherapy were 57 and 77 % in patients with and without betel nut chewing history, respectively (P = 0.038). The 2-year progression survival rates were 37 and 67 % in patients with and without betel nut chewing history, respectively (P = 0.004). The 2-year overall survival rates were 47 and 71 % in patients with and without betel nut chewing history, respectively (P = 0.017). Betel nut chewing history was independently associated with a poor response to induction chemotherapy, an inferior progression-free survival rate, and a poor overall survival rate.ConclusionsOur results indicate that betel nut chewing history is independently associated with poor prognosis in smoking patients with locally advanced HNSCC receiving induction chemotherapy with TPF. Further investigation is warranted to explain this effect of betel nut chewing history on these patients’ prognosis.

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Section: Discussionmentioning

confidence: 99%

“…Historically, tobacco smoking has been recognized as a major risk factor for HNSCC [ 7 ]. Previous studies [ 8 – 10 ] have reported that smoking was correlated with an inferior survival rate. Moreover, subjects with HNSCC who have a habit of smoking tobacco show a poor response to induction chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Chien

Luo

et al. 2016

World J Surg Onc

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“…Tobacco exposure, in addition to being the most significant risk factor for HNSCC overall, is also recognized to negatively impact treatment response and survival [66,67]. It is not unexpected, then, that tobacco use is now emerging as an important independent prognostic factor for HPV-OSCC, predicting cancer progression and risk of death in a dose-dependent fashion [6,68].…”

Section: Survival Modifiersmentioning

confidence: 99%

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

et al. 2014

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SUMMARY Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most commonly arise from the oropharynx and are responsible for the increasing incidence of oropharyngeal SCC (OSCC) in the United States (US) and abroad. HPV-positive OSCC (HPV-OSCC) has a unique demographic and risk factor profile and tumor biology. HPV-OSCC patients tend to be white, younger, and have a higher cumulative exposure to sexual behaviors as compared with HPV-negative OSCC patients. HPV-positive tumor status also significantly improves survival, and is indeed the single strongest prognostic factor for OSCC. The mechanisms that underlie the improved prognosis conferred by HPV-positive disease are unknown. The purpose of this review is to describe the clinical impact of HPV status in HNSCC, particularly in OSCC, both in terms of the unique clinic-demographic profile and prognostic implications.

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“…Studies which focus on pre- and post-treatment smoking habit describe an improved course of disease for patients who quit smoking ( 8 , 9 ). In case of treatment with primary or adjuvant radiochemotherapy (RCT), the latter is primarily associated with peritumoral tissue hypoxia-related incomplete response to RT ( 10 ), along with no response to platinum-based induction CT ( 11 ). In case of treatment by surgery only, the positive effect of smoking cessation at the time of diagnosis is attributed to improved wound healing, fewer complications such as pneumonia and a decrease in second primary malignancies ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Alteration of smoking habit at time of first diagnosis influences survival of patients with HNSCC

et al. 2020

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The impact of smoking on survival in patients with squamous cell carcinoma of the head and neck is well established, despite some conflicting data in the literature. However, data on alterations of smoking habit following cancer diagnosis is sparse. In the present study, the effect of reduction of smoking compared with cessation on the course of disease was studied. Data from 643 patients with HNSCC from the tumor documentation registry of the Department of Otorhinolaryngology, Head and Neck Surgery of the Christian-Albrechts-University Kiel were collected and statistically analyzed, looking at pre- and post-treatment smoking habit and survival. Alteration of smoking at the first diagnosis of HNSCC led to a significantly beneficial effect on survival outcomes compared with continued smoking, without significant differences between reduction and cessation of smoking. Detailed analysis revealed that this effect was solely dependent on patients treated by surgery only. Lifelong non-smokers exhibited a significant survival advantage compared with active and former smokers, with no difference in survival between these last two groups. The positive influence of altered smoking habit following first time diagnosis on disease-specific survival paralleled the negative direct effect of active smoking on therapy, which is predominantly attributed to peritumoral tissue hypoxia leading to impaired efficacy of radiochemotherapy (RCT). In the present study cohort, the positive effect of smoking habit alterations were primarily observed in patients treated by surgery only instead of RCT, possibly due to fewer perioperative complications. These findings indicated that patients should be encouraged to at least minimize smoking following cancer diagnosis. Furthermore, for survival estimates and therapy planning, former smokers should be considered as active smokers.

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Long-term survival data and prognostic factors of a complete response to chemotherapy in patients with head and neck cancer treated with platinum-based induction chemotherapy: A hellenic co-operative oncology group study

Cited by 20 publications

References 37 publications

Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Alteration of smoking habit at time of first diagnosis influences survival of patients with HNSCC

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