Long-Term Therapy with Corticosteroids in Nasal Polyposis: A Bone Metabolism Assessment

Gelardi, Matteo; Barbara, Francesco; Covelli, Ilaria; Damiani, Mario Francesco; Plantone, Francesca; Notarnicola, Angela; Moretti, Biagio; Quaranta, Nicola; Ciprandi, Giorgio

doi:10.1007/s12070-018-1466-5

Cited by 2 publications

(2 citation statements)

References 33 publications

(33 reference statements)

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“…They only speculated the occurrence of osteoporosis as with other chronic inflammatory conditions. Contrasting results from the study by Gelardi et al that assessing bone metabolism in chronic rhinosinusitis associated with nasal poliposis and long-term therapy with corticosteroids, showed that the likelihood of osteoporosis or osteopenia between affected and healthy subjects was superimposable with no statistically significant parameter predicting alterations of bone metabolism [66].…”

Section: Pollen-allergycontrasting

confidence: 59%

Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Sirufo

Suppa

Ginaldi

et al. 2020

IJMS

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Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.

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Section: Pollen-allergycontrasting

confidence: 59%

Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Sirufo

Suppa

Ginaldi

et al. 2020

IJMS

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“…It was reported by Ostergaard and colleagues in a study that included 1,362 patients that a single injection of corticosteroids have no complications and supported no concern for adrenal suppression, osteoporosis, or serious tissue atrophy [ 77 ]. Other authors have foreseen the actual safety of systemic corticosteroids without the reported side effects [ 43 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Systemic corticosteroids in treatment of chronic rhinosinusitis—A systematic review

Tamene,

Dalhoff,

Schwarz

et al. 2023

European Clinical Respiratory Journal

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Purpose When first-line chronic rhinosinusitis (CRS) treatment fails, patients can either be treated with oral or injected systemic corticosteroids. Although the EPOS and international guidelines for CRS do not mention injected corticosteroids, it is commonly used by ear, nose, and throat specialists. While the risks of systemic corticosteroids, in general, are known, the pros and cons of injected and oral corticosteroids (OCS) in CRS treatment are unclear. Methods A systematic review of studies that report the effects and/or side effects of injected and oral corticosteroids in the treatment of CRS was made according to the PRISMA guidelines. Results Altogether, 48 studies were included, only five studies reported on injected corticosteroids, and five attended with side effects. Three studies found beneficial effects of OCS perioperatively on sinus surgery, while four articles found no effect. Nineteen articles reported that OCS resulted in an improvement in symptoms. Two articles presented a longer-lasting effect of injected corticosteroids than OCS. Three studies reported adverse side effects of systemic corticosteroids, while two studies showed no adverse side effects. One study showed less adrenal suppression after injected corticosteroids compared to OCS. The evidence is not strong but shows a positive effect of systemic corticosteroids that lasts longer with injections. Conclusion Although systemic corticosteroids are widely used to treat CRS, there is a lack of studies comparing the OCS and injected corticosteroids. The evidence is sparse, however, injected steroids show longer effects with fewer side effects. An RCT study is needed to compare OCS and injected corticosteroids.

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Long-Term Therapy with Corticosteroids in Nasal Polyposis: A Bone Metabolism Assessment

Cited by 2 publications

References 33 publications

Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Systemic corticosteroids in treatment of chronic rhinosinusitis—A systematic review

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