Long-term trends in incidence and survival of penile cancer in France

Daubisse‐Marliac, Laetitia; Colonna, Marc; Trétarre, Brigitte; Défossez, Gautier; Molinié, F.; Jéhannin-Ligier, Karine; Marrer, Émilie; Grosclaude, Pascale

doi:10.1016/j.canep.2017.08.014

Cited by 30 publications

(20 citation statements)

References 24 publications

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“…Based on the data from the National Central Cancer Registry of China, the overall incidence of penile cancer in Chinese males was 0.60/100,000 and the mortality was 0.18/100,000 in 2011 . The 5‐year survival rate is over 60% in European countries, and a significant racial disparity in survival outcomes was observed between African American and Caucasian American men, indicating a difference in tumor biology for different populations …”

Section: Introductionmentioning

confidence: 99%

“…2 Based on the data from the National Central Cancer Registry of China, the overall incidence of penile cancer in Chinese males was 0.60/100,000 and the mortality was 0.18/100,000 in 2011. 4 The 5-year survival rate is over 60% in European countries, 5,6 and a significant racial disparity in survival outcomes was observed between African American and Caucasian American men, indicating a difference in tumor biology for different populations. 7 Several risk factors for penile cancer have been identified, including human papillomavirus (HPV) infection, 8 phimosis and poor hygiene, 9 smoking, 10 chronic inflammation 3,11 and socioeconomic status.…”

Section: Introductionmentioning

confidence: 99%

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Mutational landscape of penile squamous cell carcinoma in a Chinese population

Wang

Chen

et al. 2019

Intl Journal of Cancer

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Penile squamous cell carcinoma (PSCC) is a malignancy that affects the skin and tissues of the penis, but the knowledge of pathogenesis and carcinogenesis is limited. Here, we characterize the PSCC genomic landscape using whole‐exome sequencing. Of the 30 paired blood and tumor samples, we identified recurrent mutations in 11 genes; confirmed previous findings for FAT1 (4/30), HRAS (4/30), NOTCH1 (4/30), TP53 (3/30) and PIK3CA (3/30); and revealed novel candidate driver genes [CASP8 (4/30), SLITRK2 (3/30), FLG (3/30) and TRRAP (3/30)]. Our in vitro experiments suggested CASP8 was involved in mediating TRAIL‐induced apoptosis of penile cancer cell lines. We also observed the frequently altered pathways for potential therapeutic implications: alterations in the Notch (30% of sample altered), RTK–RAS (26.7% altered) and Hippo (23.3% altered) pathways accounted for over 50% of tumors. The frequently altered genes (>10%) in these pathways were proved to be expressed in penile tumors by immunohistochemistry assay. These findings provide new insight into the mutational and pathway landscapes of PSCC and suggest potential novel therapeutic opportunities for this malignancy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mutational landscape of penile squamous cell carcinoma in a Chinese population

Wang

Chen

et al. 2019

Intl Journal of Cancer

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“…The age-standardized incidence in Germany is 1.3/100,000 persons, and this rate has been stable in recent years (German Centre for Cancer Registry Data-ZfKD, data effective 07/2017). Predominantly men of advanced age are affected [69]. The relative 5-year survival rate (5YSR) in Europe is 68%.…”

Section: Penile Carcinomamentioning

confidence: 99%

Background paper for the recommendation of HPV vaccination for boys in Germany

Takla

Wiese-Posselt

Harder

et al. 2018

Bundesgesundheitsbl

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“…Although the incidence increased slightly in some areas in recent years, penile cancer (PC) was still a relatively rare malignancy in developed countries [1][2][3]. It had been showed that multiple etiologies might have contributed the occurrence of this disease, such as human papillomavirus (HPV) infection, phimosis, lichen sclerosus, smoking, condylomata acuminate, sexual problems, and chronic in ammation, etc.…”

Section: Introductionmentioning

confidence: 99%

“…: the Surveillance, Epidemiology, and End Results Program;2 : included patients whose race were not black or white.In development group, the median follow-up was 32 (95% CI, 30-36) months. However, the median of survival time was not applicable.(Fig.…”

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confidence: 99%

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Gao

Tang

Guo

et al. 2020

Preprint

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Background: We aimed to establish a prognostic nomogram for Penile Cancer (PC) patients based on the Surveillance, Epidemiology, and End Results Program (SEER) database.Methods: Data of 1694 patients between 2010 and 2015 were downloaded and extracted from the SEER database. Then, they were randomly divided into the development group (70%) and the verification group (30%). Following, the univariate and multivariate Cox proportional hazards regression was respectively used to explore the possible risk factors of PC. Factors which significantly related to the overall survival (OS) were used to establish the nomogram. Further, the concordance index (C-index), receiver operating characteristic curve (ROC) and calibration curve were used to assess the nomogram, respectively. An internal validation was carried out to test the accuracy and effectiveness of nomogram. Finally, the Kaplan-Meier calculation was used to predict the further survival status of these patients.Results: Multivariate Cox proportional hazards regression demonstrated that the independent prognostic risk factors associated with PC were age, stage T, N and M, and grade, with a moderate c-index of 0.732 [95% confidence interval (CI), 0.706-0.757] in development group and 0.743 (95% CI, 0.703-0.782) in verification group. Meanwhile, the areas under the ROC (AUC) of 3-year and 5-year survival were 0.739 and 0.727, respectively. The survival calibration curves of 3-year and 5-year brought out a high consistency. Conclusion: Our study obtained a satisfactory nomogram to reveal the survival of PC patients, which could be helpful for clinicians to assess the situation of PC patients and to implement the further treatment.

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Long-term trends in incidence and survival of penile cancer in France

Cited by 30 publications

References 24 publications

Mutational landscape of penile squamous cell carcinoma in a Chinese population

Mutational landscape of penile squamous cell carcinoma in a Chinese population

Background paper for the recommendation of HPV vaccination for boys in Germany

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

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