Long‐Term (Up to 18 Years) Clinical and Echocardiographic Results of Mitral Balloon Valvuloplasty in Children in Comparison with Adult Population

Fawzy, Mohamed; Stefadouros, Miltiadis A.; Amraoui, Souad El; Osman, Adil; Ibrahim, I. K. A.; Nowayhed, O; Eldali, Abdelmoneim; Canver, Charles C.

doi:10.1111/j.1540-8183.2008.00357.x

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…In the study from Saudi Arabia of 57 children aged 18 years, event-free survival rates at 10, 15, and 18 years were 87% + 6%, 62% + 1%, and 20% + 2%, respectively. 25 These results were not different from that reported in adults (474 patients) in the same study.…”

Section: Immediate Resultssupporting

confidence: 42%

“…In the study from Tunisia, freedom from restenosis was 61% in the group with juvenile MS. 22 A relatively high restenosis rate is reported from Saudi Arabia. 25 Restenosis developed in 26% of 57 children younger than 18 years, at a follow-up of 1.5 to 18 years (mean 8.5 + 4.8 years). A Wilkins score of more than 8 on echocardiography was predictive of restenosis.…”

Section: Immediate Resultsmentioning

confidence: 97%

“…Some of the published series on the results of BMV in young adults are shown in Table 1. [18][19][20][21][22][23][24][25] Table 2 describes three series of BMV in very young children. [26][27][28] A case report from India describes successful BMV in a four-year-old child with MS secondary to RHD.…”

Section: Immediate Resultsmentioning

confidence: 99%

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Catheter Interventions for Mitral Stenosis in Children

Saxena

2015

World J Pediatr Congenit Heart Surg

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Stenosis of the mitral valve most often occurs as a result of chronic rheumatic heart disease, causing thickening and fibrosis of the mitral valve apparatus. Rheumatic heart disease continues to be a major public health problem in several developing countries and mitral stenosis is also common in these regions. According to the reports from India and Africa, the disease tends to follow a rapidly progressive course in children. The treatment of choice is balloon dilatation of the mitral valve. Echocardiography is indispensable for this procedure. Before planning the procedure, it is essential to assess the suitability of balloon dilatation. Echocardiography performed during the procedure helps to decide whether the size of the balloon needs to be increased in case of inadequate relief of stenosis. Most published series have reported an immediate success rate of over 90% with balloon dilatation in children and young adults. With an increase in mitral valve area and improvement in functional class, the left atrial pressure and the transmitral gradients fall. These gratifying results are also reported from very young children of less than 12 years of age. It is recommended to start with a smaller balloon size and increase its size in a stepwise fashion to minimize complications. The complications, seen in about 1% to 2% of cases, include development of significant mitral regurgitation and hemopericardium, secondary to cardiac chamber perforation. The long-term results indicate slightly higher restenosis rates in children than in adults. Most children with restenosis can undergo successful repeat dilatation.

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Section: Immediate Resultssupporting

confidence: 42%

Section: Immediate Resultsmentioning

confidence: 97%

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Catheter Interventions for Mitral Stenosis in Children

Saxena

2015

World J Pediatr Congenit Heart Surg

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“…80,81 More broadly, this study introduced a possible phenotypic explanation for variable levels of reversibility of pulmonary vascular disease across WSPH groups. For example, other patient populations such as those with group 2 PH secondary to heart failure with reduced ejection fraction or valvular disease [82][83][84] exhibit different levels of disease reversal with hemodynamic unloading. How the chronicity and thus reversibility of these PH subtypes, or those driven by triggers other than hemodynamic stress, 85 depend upon shifting pulmonary endothelial phenotypes remains largely undefined.…”

Section: Coming Of Age: Endothelial Senescence Promotes Phmentioning

confidence: 99%

Endothelial Senescence: A New Age in Pulmonary Hypertension

Culley

Chan

2022

Circulation Research

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Pulmonary hypertension is an enigmatic, deleterious disease driven by multiple heterogeneous causes with a burgeoning proportion of older patients with complex, chronic comorbidities without adequate treatment options. The underlying endothelial pathophenotypes that direct vasoconstriction and panvascular remodeling remain both controversial and incompletely defined. This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. This principle proposes a more heterogeneous, dynamic pulmonary endothelium in disease; it provides a potentially unifying feature of endothelial dysfunction in pulmonary hypertension irrespective of cause; and it supports a clinically relevant link between aging and pulmonary hypertension like other chronic illnesses. Thus, taking cues from studies on aging and age-related diseases, we present possible opportunities and barriers to diagnostic and therapeutic targeting of senescence in pulmonary hypertension.

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“…Mitral stenosis (MS) is divided into rheumatic and congenital, with the latter further divided into several subtypes. Percutaneous mitral valvuloplasty has excellent outcome in selected adult patients, while in children it is mostly used for isolated rheumatic MS with excellent results, comparable to surgery [ 69 - 73 ]. A single-balloon (Inoue balloon - Toray Medical Co., Ltd.) and a double-balloon approach have been introduced with the former most commonly implemented [ 74 ].…”

Section: Mitral Stenosismentioning

confidence: 99%

Therapeutic Utilities of Pediatric Cardiac Catheterization

Moustafa

Kolokythas

Charitakis

et al. 2016

CCR

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In an era when less invasive techniques are favored, therapeutic cardiac catheterization constantly evolves and widens its spectrum of usage in the pediatric population. The advent of sophisticated devices and well-designed equipment has made the management of many congenital cardiac lesions more efficient and safer, while providing more comfort to the patient. Nowadays, a large variety of heart diseases are managed with transcatheter techniques, such as patent foramen ovale, atrial and ventricular septal defects, valve stenosis, patent ductus arteriosus, aortic coarctation, pulmonary artery and vein stenosis and arteriovenous malformations. Moreover, hybrid procedures and catheter ablation have opened new paths in the treatment of complex cardiac lesions and arrhythmias, respectively. In this article, the main therapeutic utilities of cardiac catheterization in children are discussed.

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Long‐Term (Up to 18 Years) Clinical and Echocardiographic Results of Mitral Balloon Valvuloplasty in Children in Comparison with Adult Population

Abstract: MBV is safe and effective in children with rheumatic MS. It provides better immediate results than in adults and excellent long-term results that are comparable to those seen in adults.

Cited by 10 publications

References 22 publications

Catheter Interventions for Mitral Stenosis in Children

Catheter Interventions for Mitral Stenosis in Children

Endothelial Senescence: A New Age in Pulmonary Hypertension

Therapeutic Utilities of Pediatric Cardiac Catheterization

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