Longan fruit increase bone mineral density in zebrafish and ovariectomized rat by suppressing RANKL-induced osteoclast differentiation

Son, Younglim; Lee, Eun Mi; Lee, Mi Kyung; Lee, Jong-Hun; Oh, Sangtaek

doi:10.1016/j.phymed.2019.152910

Cited by 12 publications

(6 citation statements)

References 25 publications

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“…The aqueous extract of leaves could suppress the kidney calculi [26]. In one of the studies it has been observed that the fruit extract has high anti-osteoporotic activity by inhibiting the osteoclast differentiation and thus can be used for the treatment of osteoporosis [27]. The main metabolites provide anticancer, medicinal, and anti-aging, immunomodualatory advantages to humans.…”

Section: Medicinal Propertiesmentioning

confidence: 99%

Phytomedicinal Potential of “Dimocarpus Longan Lour.” as an Essential Nutraceutical

Kathpalia¹

2022

ijcsrr

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For many centuries Longan (Dimocarpus longan Lour.) a native plant of Northeastern India, and Southeast Asia has been used for its nutraceutical properties. The phytochemicals constituents include carbohydrates, proteins, polysaccharides, vitamin C, polyphenols, that exhibit innumerable biological properties. It is essential to review the immunomodulatory, antioxidant, and phytomedicinal potential with the aim to provide a comprehensive information for future development of longan as an essential nutraceutical. Longan is in great demand as various food products viz dried pulp, frozen, fresh, and processed as jam, drinks, wine and canned fruit. The key biological activities of longan pericarp are tyrosinase inhibitory, antioxidant, anti-inflammatory, immunomodulatory, anti-glycated, anti-cancer, memory-increasing impact, and other parameters that have a significant contribution to human health.

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Section: Medicinal Propertiesmentioning

confidence: 99%

Phytomedicinal Potential of “Dimocarpus Longan Lour.” as an Essential Nutraceutical

Kathpalia¹

2022

ijcsrr

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“…Once dexamethasone or prednisolone is added to water, osteoporosis is induced in zebrafish, and potential preventing drugs can be tested ( Dietrich et al, 2021 ). Fluorescent calcein staining has also been used to test calcification in wild-type strains in standard conditions or during bone fracture modeling ( Bae et al, 2017 ; Son et al, 2019 ; Tomecka et al, 2019 ). At this point, it is necessary to acknowledge other studies that screen anti- or pro-osteogenic drugs ( de Vrieze et al, 2015 ; Chen et al, 2017 ).…”

Section: Zebrafish Models For Human Skeletal Diseasesmentioning

confidence: 99%

“…The first study has identified two pro-osteogenic and six anti-osteogenic compounds, whereas the second evaluated 77 previously characterized compounds with correct prediction for 70%. Other references have also tested the pro-osteogenic effects of chemical or extracts, such as DMP-PYT ( Bae et al, 2017 ) or Logan fruit extract ( Son et al, 2019 ), using calcein labeling. These chemical assays may provide a gold standard to be reached by alternative genetic assays.…”

Section: Zebrafish Models For Human Skeletal Diseasesmentioning

confidence: 99%

Zebrafish Models for Human Skeletal Disorders

2021

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In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a reference list of recognized diseases in humans and their causal genes published to help clinician diagnosis and scientific research advances. Complementary to mammalian models, zebrafish has emerged as an interesting species to evaluate chemical treatments against these human skeletal disorders. Due to its versatility and the low cost of experiments, more than 80 models are currently available. In this article, we review the state-of-art of this “aquarium to bedside” approach describing the models according to the list provided by the Nosology Committee. With this, we intend to stimulate research in the appropriate direction to efficiently meet the actual needs of clinicians under the scope of the Nosology Committee.

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“…Additionally, NF-κB (nuclear factor-kappa B) pathway downregulation, NFATc1 (nuclear factor of activated T-cells c1) suppression through the longan Lour fruit extract efficiently involves the suppression of osteoclast differentiation in vitro. Additionally, the administration of Lour fruit extract in vivo experiment model ovariectomized rats and zebrafish enhanced their mineral contents in bone, minimizing bone disorder risk [126,127]. Longan Lour flower H 2 O extract attenuates the serological TG (triglyceride), disaggregates the lipid moiety, and downregulates the MMP-2,9 (matrix metalloproteinases-2,9) gene expressions, thereby protecting the hepatic cells; in vitro hypercaloric-dietary rat model study [28].…”

Section: Miscellaneous Activitiesmentioning

confidence: 99%

Exhaustive Plant Profile of “Dimocarpus longan Lour” with Significant Phytomedicinal Properties: A Literature Based-Review

Paul

Biswas²,

Dey

et al. 2021

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Background: “Dimocarpus longan Lour” is a tropical and subtropical evergreen tree species mainly found in China, India, and Thailand; this plant, found naturally in Bangladesh, even locally, is used as “kaviraj” medication for treating different diseases, such as gastrointestinal disorders, wounds, fever, snake bites, menstrual problem, chickenpox, bone fractures, neurological disorders, and reproductive health. Different parts of this plant, especially juice pulp, pericarp, seeds, leaves, and flowers, contain a diverse group of botanical phytocompounds, and nutrient components which are directly related to alleviating numerous diseases. This literature-based review provides the most up-to-date data on the ethnomedicinal usages, phytochemical profiling, and bio-pharmacological effects of D. longan Lour based on published scientific articles. Methodology: A literature-based review was conducted by collecting information from various published papers in reputable journals and cited organizations. ChemDraw, a commercial software package, used to draw the chemical structure of the phytochemicals. Results: Various phytochemicals such as flavonoids, tannins, and polyphenols were collected from the various sections of the plant, and other compounds like vitamins and minerals were also obtained from this plant. As a treating agent, this plant displayed many biologicals activities, such as anti-proliferative, antioxidant, anti-cancer, anti-tyrosinase, radical scavenging activity, anti-inflammatory activity, anti-microbial, activation of osteoblast differentiation, anti-fungal, immunomodulatory, probiotic, anti-aging, anti-diabetic, obesity, neurological issues, and suppressive effect on macrophages cells. Different plant parts have displayed better activity in different disease conditions. Still, the compounds, such as gallic acid, ellagic acid, corilagin acid, quercetin, 4-O-methyl gallic acid, and (-)-epicatechin showed better activity in the biological system. Gallic acid, corilagin, and ellagic acid strongly exhibited anti-cancer activity in the HepG2, A549, and SGC 7901 cancer cell lines. Additionally, 4-O-methyl gallic acid and (-)-epicatechin have displayed outstanding antioxidant activity as well as anti-cancer activity. Conclusion: This plant species can be considered an alternative source of medication for some diseases as it contains a potential group of chemical constituents.

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Longan fruit increase bone mineral density in zebrafish and ovariectomized rat by suppressing RANKL-induced osteoclast differentiation

Cited by 12 publications

References 25 publications

Phytomedicinal Potential of “Dimocarpus Longan Lour.” as an Essential Nutraceutical

Phytomedicinal Potential of “Dimocarpus Longan Lour.” as an Essential Nutraceutical

Zebrafish Models for Human Skeletal Disorders

Exhaustive Plant Profile of “Dimocarpus longan Lour” with Significant Phytomedicinal Properties: A Literature Based-Review

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