Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span

Wit, Janneke; Sarup, Pernille; Lupsa, Nikolett; Malte, Hans; Frydenberg, Jane; Loeschcke, Volker

doi:10.1016/j.exger.2013.01.008

Cited by 38 publications

(54 citation statements)

References 84 publications

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“…Finally, some studies have failed to detect the presence of antagonistic pleiotropy -even when measuring multiple facets of lifetime fertility. 100,105,106 These studies suggest that either mutation accumulation is the primary cause of reproductive senescence or that the particular measure(s) of fertility selected are not those involved in the negative genetic correlation with late life fitness. 105 Studies supporting the existence of antagonistic pleiotropy have also encountered challenges regarding gene-environment interactions and unintended selection for reproductive traits.…”

Section: The Genetic Basis and Architecture Of Female Reproductive Sementioning

confidence: 99%

“…103,104 In other cases, a role for mutation accumulation has been inferred by the failure to document antagonistic pleiotropy. 105,106 However, lab stock cultures maintained with short (2 week) generation times may permit late-acting mutations with deleterious effects to accumulate, thereby resulting in environmental-induced evidence for mutation accumulation. 26,107,108 Multiple studies designed to detect a role for antagonistic pleiotropy on reproductive senescence have generated various levels of support for its existence (reviewed in 106 ).…”

Section: The Genetic Basis and Architecture Of Female Reproductive Sementioning

confidence: 99%

“…105,106 However, lab stock cultures maintained with short (2 week) generation times may permit late-acting mutations with deleterious effects to accumulate, thereby resulting in environmental-induced evidence for mutation accumulation. 26,107,108 Multiple studies designed to detect a role for antagonistic pleiotropy on reproductive senescence have generated various levels of support for its existence (reviewed in 106 ). Evidence for antagonistic pleiotropy consists of documenting a negative genetic correlation between longevity and early fecundity (or other early-late life measures of fertility) (described in 101 ).…”

Section: The Genetic Basis and Architecture Of Female Reproductive Sementioning

confidence: 99%

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The song of the old mother: Reproductive senescence in female drosophila

Miller

Obrik-Uloho

Phan

et al. 2014

Fly

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Among animals with multiple reproductive episodes, changes in adult condition over time can have profound effects on lifetime reproductive fitness and offspring performance. The changes in condition associated with senescence can be particularly acute for females who support reproductive processes from oogenesis through fertilization. The pomace fly Drosophila melanogaster is a well-established model system for exploring the physiology of reproduction and senescence. In this review, we describe how increasing maternal age in Drosophila affects reproductive fitness and offspring performance as well as the genetic foundation of these effects. Describing the processes underlying female reproductive senescence helps us understand diverse phenomena including population demographics, conditiondependent selection, sexual conflict, and transgenerational effects of maternal condition on offspring fitness. Understanding the genetic basis of reproductive senescence clarifies the nature of life-history trade-offs as well as potential ways to augment and/or limit female fertility in a variety of organisms.

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Section: The Genetic Basis and Architecture Of Female Reproductive Sementioning

confidence: 99%

Section: The Genetic Basis and Architecture Of Female Reproductive Sementioning

confidence: 99%

Section: The Genetic Basis and Architecture Of Female Reproductive Sementioning

confidence: 99%

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The song of the old mother: Reproductive senescence in female drosophila

Miller

Obrik-Uloho

Phan

et al. 2014

Fly

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“…A trade-off between reproduction and longevity did not emerge when C. elegans was subjected to condition-dependent rather than random mortality (Chen and Maklakov 2012). In Drosophila selected for extended longevity, females had similar or even higher fecundity throughout life, and stress resistance, metabolic rate, maturation time, and body size also had no correlation with life span (Wit et al 2013). Similarly, exceptional longevity of Rottweiler dogs was not limited by female reproductive effort (Kengeri et al 2013).…”

Section: Trade-offs and Life Extensionmentioning

confidence: 99%

Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

Hans

Lone

Aksenov

et al. 2015

AGE

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We examined the impacts of aspirin and metformin on the life history of the cricket Acheta domesticus (growth rate, maturation time, mature body size, survivorship, and maximal longevity). Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls). Increases in general survivorship were even more pronounced, with low-dose aspirin yielding mean longevity 234 % of controls (i.e., health span). Metformin strongly reduced growth rates of both genders (<60 % of controls), whereas aspirin only slightly reduced the growth rate of females and slightly increased that of males. Both drugs delayed maturation age relative to controls, but metformin had a much greater impact (>140 % of controls) than aspirin (~118 % of controls). Crickets maturing on low aspirin showed no evidence of a trade-off between maturation mass and life extension. Remarkably, by 100 days of age, aspirin-treated females were significantly larger than controls (largely reflecting egg complement). Unlike the reigning dietary restriction paradigm, low aspirin conformed to a paradigm of Beat more, live longer.^In contrast, metformin-treated females were only~67 % of the mass of controls. Our results suggest that hormetic agents like metformin may derive significant trade-offs with life extension, whereas health and longevity benefits may be obtained with less cost by agents like aspirin that regulate geroprotective pathways.

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“…This pattern is interpreted as evidence for the involvement of alleles with antagonistic pleiotropic effects in the evolution of aging and reproduction. However, EF and longevity can sometimes be decoupled (Khazaeli and Curtsinger 2013;Wit et al 2013;Kimber and Chippindale 2013).…”

Section: Introductionmentioning

confidence: 99%

Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster

2015

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Quantitative trait loci (QTL) were mapped for longevity and fecundity at two temperatures, 20 and 30 °C, in two sets of recombinant inbred lines (RIL) highly differing in thermotolerance. Early fecundity (EF) and longevity showed a negative association between temperatures. For instance, longevity was higher and fecundity was lower in the RIL panel showing higher life span at 30 °C. One X-linked QTL (7B3-12E) co-localized for longevity and EF at 20 °C, with one QTL allele showing a positive additive effect on longevity and a negative effect on EF. The across-RIL genetic correlation between longevity and EF was not significant within each temperature, and most QTL that affect life span have no effect on EF at each temperature. EF and longevity can mostly be genetically uncoupled in the thermotolerance-divergent RIL within each temperature as opposed to between temperatures. QTL were mostly temperature specific, although some trait-specific QTL showed possible antagonistic effects between temperatures.

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Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span

Cited by 38 publications

References 84 publications

The song of the old mother: Reproductive senescence in female drosophila

The song of the old mother: Reproductive senescence in female drosophila

Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster

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