Longitudinal Anthropometry and Body Composition in Children With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome

Profio, Elisabetta Di; Vizzuso, Sara; Fiore, Giulia; Pascuzzi, Martina Chiara; Agostinelli, Marta; Dilillo, Dario; Mannarino, Savina; Fiori, Laura M.; D’Auria, Enza; Fabiano, Valentina; Carlucci, Paolo; Bova, Stefania Maria; Zoia, Elena; Bosetti, Alessandra; Calcaterra, Valeria; Bertoli, Simona; Verduci, Elvira; Zuccotti, Gian Vincenzo

doi:10.1097/mpg.0000000000003705

Cited by 7 publications

(2 citation statements)

References 40 publications

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“…В работе E. Di Profio с соавт. [12] приводятся результаты исследования состава тела в большой по численности популяции детей, перенесших острую форму COVID-19, а также обследованные спустя 6 месяцев после выздоровления. ИМТ и другие антропометрические параметры, связанные с жировым компонентом тела, были значительно выше через 6 месяцев после перенесенного заболевания.…”

Section: индекс массы тела и Covid-19unclassified

Anthropometric Indices in Predicting the Risks of Occurrence and Outcomes of Diseases at Present Stage

Nikityuk,

Klochkova,

Alexeeva

et al. 2024

Žurnal anatomii i gistopatologii

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This paper presents a literature review evaluating the possibilities of using anthropometry and anthropometric indices at the present stage of development of science and medicine, taking into account a personalized approach to predicting life and health indicators of various population groups. To prepare this review, an analysis of the literature of the PubMed database within 2022–2023 was carried out using the keywords “anthropometry”, “body mass index”. 44 of the 643 sources cited, were included in the final version. The use of body mass index appears to be a cost-effective, relevant and simple method for application in scientific research, preventive and clinical medicine and a personalized approach to solving a wide range of problems.

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Section: индекс массы тела и Covid-19unclassified

Anthropometric Indices in Predicting the Risks of Occurrence and Outcomes of Diseases at Present Stage

Nikityuk,

Klochkova,

Alexeeva

et al. 2024

Žurnal anatomii i gistopatologii

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“…Longitudinal studies revealed that COVID-19 infections may cause various types of malnutrition in children. 6 Although the negative effect of COVID-19 infection on nutritional status has been well defined in adults, the impact of malnutrition on the clinical course and outcomes of MIS-C is not clear in the pediatric population.…”

Section: The Role Of Malnutrition On Outcomes Of Multisystem Inflamma...mentioning

confidence: 99%

The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19

Soyer,

Aykaç,

Özer

et al. 2024

Turk J Pediatr

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Background. Malnutrition increases the complications and mortality in critically-ill children. We performed a retrospective analysis to define the impact of malnutrition on the outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19. Methods. Patients with MIS-C were evaluated for demographic features, anthropometric parameters, clinical findings and outcomes. Patients with z scores of body mass index (> 5 years) and weight-for-age (< 5 years) < -2 were considered malnourished. Sarcopenia was defined by total psoas muscle area (tPMA), calculated on abdominal computed tomography (CT) at the level of L3 and L4 vertebrae. The z scores <- 2 for tPMA were considered sarcopenia. The results of patients with and without malnutrition were compared. Results. Twenty-seven patients were included. Forty-four percent (n=12) of patients had malnutrition. Malnutrition was classified as mild to moderate (1/3), severe (1/3) and overweight (1/3). Eighty-two % of cases had acute malnutrition. Among MIS-C symptom criteria, rash was significantly higher in children with malnutrition (p<0.05). Laboratory investigations showed higher ferritin levels in patients with malnutrition (p<0.05). The median tPMA and sarcopenia were significantly higher in patients with malnutrition when compared to patients without malnutrition (42% vs 7%, p<0.05). The oral feeding time, complication rates, and length of hospital stay were similar in both groups (p>0.05). Conclusion. Children with MIS-C already had mild to severe malnutrition at admission. Rash and higher ferritin levels were more common in patients with malnutrition. In addition to anthropometric parameters, sarcopenia calculated using tPMA can be used to predict malnutrition in critically-ill children.

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Long−term health outcome and quality of life in children with multisystem inflammatory syndrome: findings from multidisciplinary follow−up at an Italian tertiary−care paediatric hospital

D’Auria,

Bova,

Dallapiccola

et al. 2024

Eur J Pediatr

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Multisystem inflammatory syndrome is a severe complication of SARS-CoV-2 infection in children (MIS-C). To date, data on long-term sequelae mainly concern cardiac outcomes. All ≤ 18 year olds consecutively admitted to the Buzzi Children’s Hospital with a diagnosis of MIS-C between October 1, 2020, and May 31, 2022, were followed up for up to 12 months by a dedicated multidisciplinary team. They underwent laboratory tests, multi-organ clinical and instrumental assessments, and psychosocial evaluation. 56/62 patients, 40 M, mean age 8.7 years (95% CI 7.7, 9.7), completed the follow-up. Cardiological, gastroenterological, pneumological, and neurological evaluations, including IQ and EEG, were normal. Alterations of HOMA-IR index and/or TyG index, observed in almost all patients during hospitalisation, persisted in about a third of the population at 12 months. At 6 and 12 months respectively, impairment of adaptive functions was observed in 38/56 patients (67.9%) and 25/56 (44.6%), emotional and behavioural problems in 10/56 (17.9%) and 9/56 (16.1%), and decline in QoL in 14/56 (25.0%) and 9/56 (16.1%). Psychosocial well-being impairment was significantly more frequent in the subgroup with persistent glycometabolic dysfunction at 12 months (75% vs. 40.9% p < 0.001).Conlusion: The mechanisms that might explain the long-term persistence of both metabolic alterations and neuro-behavioural outcomes and their possible relationship are far from being clarified. Our study points out to the potential long-term effects of pandemics and to the importance of a multidisciplinary follow-up to detect potential negative sequelae in different areas of health, both physical and psychosocial. What is known:• Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection.• Few data exist on the medium- and long-term outcomes of MIS-C, mostly focused on cardiac involvement. Emerging evidence shows neurological and psychological sequelae at mid- and long-term follow-up. What is new:• This study reveals that MIS-C may lead to long-term glycometabolic dysfunctions joined to impairment in the realm of general well-being and decline in quality of life, in a subgroup of children.• This study highlights the importance of a long-term multidisciplinary follow-up of children hospitalised with MIS-C, in order to detect the potential long-term sequelae in different areas of health, both physical and psychosocial well-being.

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Longitudinal Anthropometry and Body Composition in Children With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome

Cited by 7 publications

References 40 publications

Anthropometric Indices in Predicting the Risks of Occurrence and Outcomes of Diseases at Present Stage

Anthropometric Indices in Predicting the Risks of Occurrence and Outcomes of Diseases at Present Stage

The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19

Long−term health outcome and quality of life in children with multisystem inflammatory syndrome: findings from multidisciplinary follow−up at an Italian tertiary−care paediatric hospital

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