Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented
            <i>APOE</i>
            ε4 carriers

Gorbach, Tetiana; Pudas, Sara; Bartrés‐Faz, David; Brandmaier, Andreas M.; Düzel, Sandra; Henson, Rna; Idland, Ane‐Victoria; Lindenberger, Ulman; Bros, Didac Macià; Mowinckel, Athanasia M.; Solé‐Padullés, Cristina; Sørensen, Øystein; Walhovd, Kristine B.; Watne, Leiv Otto; Westerhausen, René; Fjell, Anders M.; Nyberg, Lars

doi:10.1002/dad2.12110

Cited by 20 publications

(21 citation statements)

References 51 publications

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“…Because this was a study with rolling recruitment, sample size increased at each wave of assessment (see Table 1 ). Exclusion criteria included severe visual or auditory impairment, intellectual or developmental disabilities, suspected dementia, having a mother tongue other than Swedish, any contraindication to MRI, neurological disorders, Mini-Mental State Examination (MMSE) < 24, brain surgery or substantial anatomical deviations ( Nilsson et al, 1997 ; Gorbach et al, 2020 ). BASE-II cohort included healthy community-dwelling older adults living in the greater Berlin metropolitan area with normal or corrected to normal vision.…”

Section: Methodsmentioning

confidence: 99%

No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study

Solé‐Padullés

Macià

Andersson

et al. 2022

Front. Aging Neurosci.

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BackgroundLoneliness is most prevalent during adolescence and late life and has been associated with mental health disorders as well as with cognitive decline during aging. Associations between longitudinal measures of loneliness and verbal episodic memory and brain structure should thus be investigated.MethodsWe sought to determine associations between loneliness and verbal episodic memory as well as loneliness and hippocampal volume trajectories across three longitudinal cohorts within the Lifebrain Consortium, including children, adolescents (N = 69, age range 10–15 at baseline examination) and older adults (N = 1468 over 60). We also explored putative loneliness correlates of cortical thinning across the entire cortical mantle.ResultsLoneliness was associated with worsening of verbal episodic memory in one cohort of older adults. Specifically, reporting medium to high levels of loneliness over time was related to significantly increased memory loss at follow-up examinations. The significance of the loneliness-memory change association was lost when eight participants were excluded after having developed dementia in any of the subsequent follow-up assessments. No significant structural brain correlates of loneliness were found, neither hippocampal volume change nor cortical thinning.ConclusionIn the present longitudinal European multicenter study, the association between loneliness and episodic memory was mainly driven by individuals exhibiting progressive cognitive decline, which reinforces previous findings associating loneliness with cognitive impairment and dementia.

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Section: Methodsmentioning

confidence: 99%

No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study

Solé‐Padullés

Macià

Andersson

et al. 2022

Front. Aging Neurosci.

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“…As previously described ( Gorbach et al. 2020 ), each participating study contributed 1 or several episodic-memory measures.…”

Section: Methodsmentioning

confidence: 99%

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

et al. 2022

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It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

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“…Important aspects of brain health can be measured by structural MRI, which is sensitive to brain changes in aging 20 and a range of clinical conditions such as AD 21 . Global brain volume is consistently related to higher general cognitive function 22 , and volumetric loss in specific regions has been shown to be associated with reduction of functions such as memory 23 . Effect sizes are modest, but it is established that in adulthood, larger regional brain volumes, thicker cortex and smaller ventricles are associated with higher cognitive function and less risk for cognitive decline 24 .…”

Section: Introductionmentioning

confidence: 99%

Sleep duration and brain structure – phenotypic associations and genotypic covariance

Fjell

Sørensen

Wang

et al. 2022

Preprint

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The question of how much sleep is best for the brain attracts scientific and public interest, and there is concern that insuficient sleep leads to poorer brain health. However, it is unknown how much sleep is sufficient and how much is too much. We analyzed 51,295 brain magnetic resonnance images from 47,039 participants, and calculated the self-reported sleep duration associated with the largest regional volumes and smallest ventricles relative to intracranial volume (ICV) and thickest cortex. 6.8 hours of sleep was associated with the most favorable brain outcome overall. Critical values, defined by 95% confidence intervals, were 5.7 and 7.9 hours. There was regional variation, with for instance the hippocampus showing largest volume at 6.3 hours. Moderately long sleep (> 8 hours) was more strongly associated with smaller relative volumes, thinner cortex and larger ventricles than even very short sleep (< 5 hours), but effect sizes were modest. People with larger ICV reported longer sleep (7.5 hours), so not correcting for ICV yielded longer durations associated with maximal volume. Controlling for socioeconomic status, body mass index and depression symptoms did not alter the associations. Genetic analyses showed that genes related to longer sleep in short sleepers were related to shorter sleep in long sleepers. This may indicate a genetically controlled homeostatic regulation of sleep duration. Mendelian randomization analyses did not suggest sleep duration to have a causal impact on brain structure in the analyzed datasets. The findings challenge the notion that habitual short sleep is negatively related to brain structure.

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Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers

Cited by 20 publications

References 51 publications

No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study

No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Sleep duration and brain structure – phenotypic associations and genotypic covariance

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