Longitudinal association between periodontitis and development of diabetes

Joshipura, Kaumudi; Muñoz‐Torres, Francisco J.; Dye, Bruce A.; Ramírez-Vick, Margarita; Pérez, Cynthia M.

doi:10.1016/j.diabres.2018.04.028

Cited by 56 publications

(57 citation statements)

References 37 publications

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“…Several important works not included in our study were worth reading. Chiu's study [62] and Joshipura's study [74] found PD could increase the risk of developing pre-diabetes. Demmer's study [75] found PD was associated with 5-year HbA1c progression.…”

Section: Discussionmentioning

confidence: 95%

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Yuan

Liu

et al. 2019

Preprint

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ObjectivesTo systematically reviewing the epidemiologic relationship between periodontitis (PD) and type 2 diabetes mellitus (T2DM). Materials and MethodsFour electronic databases were searched up to December, 2018. Manual search including the reference lists of included studies and relevant journals. Observational studies evaluating the relationship between T2DM and PD were included. Meta-analyses were applied using STATA. ResultsA total of 53 observational studies were included. Pooled results of cross-sectional studies found the strength of association between these two diseases was very strong (OR=3.27, p=0.000). Adjusted T2DM prevalence was significantly higher in PD patients (OR=4.04, p=0.000) and vice versa (OR=1.58, p=0.000). T2DM patients had significantly worse periodontal status, reflected in a 0.61mm deeper periodontal pocket, a 0.89mm higher attachment loss and about 2 more lost teeth (all p=0.000). Results of cohort studies found T2DM could elevate 27% risk of developing PD (p=0.000).Glycemic control state of T2DM might result in different PD outcomes. Severe PD increased 53% of incident T2DM (p=0.000) and this result was stable. In contrast, the impact of mild PD on T2DM incidence (RR=1.28, p=0.007) was less robust. ConclusionsThere is an evident bidirectional relationship between T2DM and periodontitis. Further well-designed cohort studies are needed to confirm this. Clinical RelevanceBoth dentists and physicians need to be aware of this strong connection between PD and T2DM.Control these two diseases might benefit the prevention of the incidence of each other.

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Section: Discussionmentioning

confidence: 95%

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Yuan

Liu

et al. 2019

Preprint

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“…Several important works, though notable, were not included in our study. Chiu's study [62] and Joshipura's study [74] found that periodontitis could increase the risk of developing prediabetes. Demmer's study [75] found that periodontitis was associated with 5-year HbA1c progression.…”

Section: Discussionmentioning

confidence: 97%

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

et al. 2020

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Background: To systematically review the epidemiologic relationship between periodontitis and type 2 diabetes mellitus (T2DM). Methods: Four electronic databases were searched up until December 2018. The manual search included the reference lists of the included studies and relevant journals. Observational studies evaluating the relationship between T2DM and periodontitis were included. Meta-analyses were conducted using STATA. Results: A total of 53 observational studies were included. The Adjusted T2DM prevalence was significantly higher in periodontitis patients (OR = 4.04, p = 0.000), and vice versa (OR = 1.58, p = 0.000). T2DM patients had significantly worse periodontal status, as reflected in a 0.61 mm deeper periodontal pocket, a 0.89 mm higher attachment loss and approximately 2 more lost teeth (all p = 0.000), than those without T2DM. The results of the cohort studies found that T2DM could elevate the risk of developing periodontitis by 34% (p = 0.002). The glycemic control of T2DM patients might result in different periodontitis outcomes. Severe periodontitis increased the incidence of T2DM by 53% (p = 0.000), and this result was stable. In contrast, the impact of mild periodontitis on T2DM incidence (RR = 1.28, p = 0.007) was less robust. Conclusions: There is an evident bidirectional relationship between T2DM and periodontitis. Further well-designed cohort studies are needed to confirm this finding. Our results suggest that both dentists and physicians need to be aware of the strong connection between periodontitis and T2DM. Controlling these two diseases might help prevent each other's incidence.

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“…The relationship between diabetes and periodontitis is bidirectional, with each conferring a higher risk of the other (18,19). Epidemiologic studies have confirmed that diabetes is an important risk factor for periodontitis, and it has been recognized that periodontitis is the sixth-most frequent complication of diabetes (20). The incidence rate of periodontitis in diabetics is obviously higher.…”

Section: Clinical and Epidemiologic Characteristics Of Oral Bone Metamentioning

confidence: 99%

Current Knowledge Regarding the Interaction Between Oral Bone Metabolic Disorders and Diabetes Mellitus

Wang

Tian-fu

et al. 2020

Front. Endocrinol.

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Diabetes mellitus, a major chronic disease affecting human health, has been increasing in prevalence in recent years. Diabetes mellitus can cause bone metabolic disorders in patients, leading to osteoporosis, a higher risk of traumatic fracture, and other bone diseases. Bone metabolic disorders in the oral cavity principally manifest as periodontitis, loss of alveolar bone, and failure of implant osseointegration. In recent years, numerous studies have shown that there is a complex interaction between bone metabolic disorders and diabetes mellitus. This paper reviews the adverse effects of diabetes on oral bone metabolism disorders such as alveolar osteoporosis and bone loss in patients with periodontitis, discusses the potential mechanisms of diabetic bone loss, and suggests potential ways to prevent and treat oral bone loss in patients with diabetes mellitus.

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Longitudinal association between periodontitis and development of diabetes

Abstract: There is no association between periodontitis and risk of prediabetes/diabetes in this longitudinal study.

Cited by 56 publications

References 37 publications

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Current Knowledge Regarding the Interaction Between Oral Bone Metabolic Disorders and Diabetes Mellitus

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