2023
DOI: 10.1002/alz.13137
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Longitudinal changes in metabolic network activity in early Alzheimer's disease

Abstract: INTRODUCTIONThe progression of Alzheimer's disease (AD) has been linked to two metabolic networks, the AD‐related pattern (ADRP) and the default mode network (DMN).METHODSConverting and clinically stable cognitively normal subjects (n = 47) and individuals with mild cognitive impairment (n = 96) underwent 2‐[18F]fluoro‐2‐deoxy‐D‐glucose (FDG) positron emission tomography (PET) three or more times over 6 years (nscans = 705). Expression levels for ADRP and DMN were measured in each subject and time point, and t… Show more

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Cited by 5 publications
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“… 10 , 11 Furthermore, recent work suggests that AD progression clinically is linked to alterations in metabolic activity of brain networks (default mode network and AD‐related pattern) measured by 18 F‐FDG PET. 12 …”
Section: Introductionmentioning
confidence: 99%
“… 10 , 11 Furthermore, recent work suggests that AD progression clinically is linked to alterations in metabolic activity of brain networks (default mode network and AD‐related pattern) measured by 18 F‐FDG PET. 12 …”
Section: Introductionmentioning
confidence: 99%