Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell Inner Plexiform Layer in Progressive Myopia and Glaucoma Among Adolescents

Xiao, Hui; Zhong, Yimin; Ling, Yuye; Xu, Xiaoyu; Liu, Xing

doi:10.3389/fmed.2022.828991

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Furthermore, several reports have indicated that postrecovery SARS-CoV-2 patients have a significantly thinner RNFL than healthy individuals [ 18 , 32 , 33 ]. And a reduced RNFL thickness has been linked to an increased risk of various diseases, such as Alzheimer's disease and glaucoma [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 neurovascular invasion supported by Mendelian randomization

Pan,

Zhang,

2024

J Transl Med

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Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to affect vessels and nerves and can be easily visualized in the retina. However, the effect of SARS-CoV-2 on retinal morphology remains controversial. In the present research, we applied Mendelian randomization (MR) analysis to estimate the association between SARS-CoV-2 and changes in the thickness of the inner retina. Methods Two-sample MR analysis was conducted using summary-level data from 3 open genome-wide association study databases concerning COVID-19 infection (2,942,817 participants) and COVID-19 hospitalization (2,401,372 participants); moreover, the dataset of inner retina thickness, including the macular retinal nerve fiber layer (mRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL), included 31,434 optical coherence tomography (OCT) images derived from healthy UK Biobank participants. All the participants were of European ancestry. The inverse variance weighted (IVW) meta-analysis was used as our primary method. Various complementary MR approaches were established to provide robust causal estimates under different assumptions. Results According to our MR analysis, genetically predicted COVID-19 infection was associated with an increased risk of mRNFL and mGCIPL thickness (OR = 1.74, 95% CI 1.20–2.52, P = 3.58 × 10–3; OR = 2.43, 95% CI 1.49–3.96, P = 3.6 × 10–4). The other MR methods produced consistent results. However, genetically predicted COVID-19 hospitalization did not affect the thickness of the inner retina (OR = 1.11, 95% CI 0.90–1.37, P = 0.32; OR = 1.28, 95% CI 0.88–1.85, P = 0.19). Conclusion This work provides the first genetically predictive causal evidence between COVID-19 infection and inner retinal thickness in a European population. These findings will contribute to further understanding of the pathogenesis of COVID-19 and stimulate improvements in treatment modalities.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 neurovascular invasion supported by Mendelian randomization

Pan,

Zhang,

2024

J Transl Med

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Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews

KhalafAllah,

Fuchs,

Nugen

et al. 2024

Experimental Eye Research

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The use of optical coherence tomography in neurology: a review

Xie

Donaldson

Margolin

2022

Brain

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Optical coherence tomography (OCT) is a non-invasive, cost-efficient technique that provides high-resolution in vivo imaging of retinal tissue. The peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell complex (mGCC) are surrogate markers of neuroaxonal integrity in not only the eye, but also the central nervous system. Retinal atrophy may occur in tandem with central nervous system pathologies as a result of injury to ganglion cells, direct degeneration of the pregeniculate pathway, or retrograde transsynaptic degeneration secondary to postgeniculate lesions. In this review, we outline the basic principles of OCT and discuss its application to managing patients with demyelinating disorders, idiopathic intracranial hypertension, stroke, neurodegenerative conditions, and mitochondrial disorders. We demonstrate that measurements of pRNFL and mGCC thickness are paramount in diagnosing and monitoring neurologic disorders, including those with subclinical disease progression.

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Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell Inner Plexiform Layer in Progressive Myopia and Glaucoma Among Adolescents

Cited by 3 publications

References 37 publications

SARS-CoV-2 neurovascular invasion supported by Mendelian randomization

SARS-CoV-2 neurovascular invasion supported by Mendelian randomization

Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews

The use of optical coherence tomography in neurology: a review

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